Gut Permeability / Leaky Gut

Herbal medicine WangShiBaoChiWan improves gastrointestinal health in mice via modulation of intestinal tight junctions and gut microbiota and inhibition of inflammation

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Vitamins / Supplements / Nutraceuticals /

WSBCW upregulated intestinal junction proteins, increased the abundance of Bifidobacterium genus, Desulfovibrio genus and inhibited Bacteroides fragillis group in the gut microbiota, increased intestinal villi lengths, and decreased blood levels of inflammatory cytokines. Our study provided preclinical evidence to verify the effectiveness of WSBCW in gastrointestinal health and elucidate mechanistic insights. The results warrant further investigations to evaluate the […]

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Effects of niacin on intestinal immunity, microbial community and intestinal barrier in weaned piglets during starvation

Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Pre-PD, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

In conclusion, niacin attenuated the weight loss and diarrhea, and improved the expression of antimicrobial peptides, and enhanced intestinal epithelial barrier function, and improved the microbiota in the colonic contents of weaned piglets, suggesting that niacin may be an effective way for weaned piglets to maintain the gut and overall health. CLICK TO REVIEW

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Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Metabolites, Pre-PD /

These findings suggest that varieties in dietary patterns result in the production of diverse microbial fermentation metabolites, which contribute to gut microbiome homeostasis through multiple manipulations including immune modulation, inflammation restriction as well as epithelial barrier maintenance, thus finally determine the fate of UC progression and give implications for functional food development for prevention and

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Dietary restrictions modulate the gut microbiota: Implications for health and disease

Biomarkers, Butyrate, Diet and Exercise, Gut Permeability / Leaky Gut, Gut-Brain axis /

The data suggests that changing the gut microbiota composition by dietary restriction has the potential to positively influence the progression of several diseases such as obesity, diabetes, neurological diseases or inflammatory bowel disease. Finally, the relevance of the findings for clinical practice is evaluated and approaches for future research are proposed. CLICK TO REVIEW

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Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson’s disease

Biomarkers, Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Lipopolysaccharides (LPS), Metabolites, Short Chain Fatty Acids, Zonulin /

Previous studies have reported that gut microbiota, permeability, short-chain fatty acids (SCFAs), and inflammation are altered in Parkinson’s disease (PD), but how these factors are linked and how they contribute to disease processes and symptoms remains uncertain. This study sought to compare and identify associations among these factors in PD patients and controls to elucidate

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Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation

Biomarkers, Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Metabolites, Pre-PD, Short Chain Fatty Acids /

We found significant alterations in the PD-associated microbiome, which are robust to study-specific technical heterogeneities, although differences in microbiome structure between PD and controls are small. Enrichment of the genera Lactobacillus, Akkermansia, and Bifidobacterium and depletion of bacteria belonging to the Lachnospiraceae family and the Faecalibacterium genus, both important short-chain fatty acids producers, emerged as

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Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

Butyrate, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Lipopolysaccharides (LPS), Probiotics, Prebiotics and Symbiotics /

The gut microbiota (GM) represents a diverse and dynamic population of microorganisms and about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies suggest that the GM can influence the health of the host, and several factors can modify the GM composition, such as diet, drug intake, lifestyle, and geographical locations. Gut

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The Aged Intestine: Performance and Rejuvenation

Biomarkers, ENS, Gut Permeability / Leaky Gut /

Owing to the growing elderly population, age-related problems are gaining increasing attention from the scientific community. With senescence, the intestine undergoes a spectrum of changes and infirmities that are likely the causes of overall aging. Therefore, identification of the aged intestine and the search for novel strategies to rescue it, are required. Although progress has

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Why Researchers Look to Gut Microbial Metabolites in Parkinson’s Disease

Gut Microbiota, Gut Permeability / Leaky Gut, Metabolites, Short Chain Fatty Acids, Symptoms / Diagnosis /

Findings highlight significant differences in the fecal microbiome and metabolome in patients with Parkinson’s disease and control subjects, demonstrating an important connection between the brain and gut that could influence the disease process and progression. CLICK TO REVIEW

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