iRBD

Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson’s disease

A-Synuclein, Gut-Brain axis, iRBD /

Alpha-synucleinopathy is postulated to be central to both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson’s disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein and glymphatic system dysfunction. However, evidence accumulating primarily based on clinical data to support glymphatic system dysfunction in patients with iRBD and PD is […]

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New research reveals sleep disorder may be linked to Parkinson’s

iRBD, Parkinson's Disease, Pre-PD /

New research on the connection between sleep and Parkinson’s disease is being hailed as a “first step” toward curing and preventing the condition, a brain disorder that causes uncontrollable movements. The research, led by the Parkinson’s Progression Markers Initiative, funded by The Michael J. Fox Foundation, is working to make a concrete connection between Parkinson’s and REM sleep

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Phenoconversion Risk Factors in Rapid Eye Movement Sleep Behavior Disorder

Biomarkers, Enviromental, iRBD, Parkinson's Disease, Pesticides, Pre-PD /

A multicenter cohort of idiopathic/isolated rapid eye movement sleep behavior disorder (iRBD) was studied to determine any predictive factors for α-synuclein–related neurodegenerative illnesses. At the start of the study, patients with iRBD from 12 different sites were given a complete assessment for potential environmental and lifestyle risk factors using a standardized questionnaire. Patients were then

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Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progression

iRBD, Parkinson's Disease, Pre-PD /

The course of REM sleep behavior disorder (RBD) variates in the early stage of Parkinson’s disease. We aimed to delineate the association between the evolution pattern of probable RBD (pRBD) and the progression of Parkinson’s disease (PD). 281 de novo PD patients from the Parkinson’s Progression Markers Initiative database were included. Patients were followed up

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Sleep Disorders and Autonomic Nervous System Dysfunction

iRBD, Pre-PD /

Parasympathetic nervous system activity dominates during non-rapid eye movement (REM) sleep, whereas the sympathetic nervous system is dominant during REM sleep. The balance between the sympathetic and parasympathetic nervous systems reduces the heart rate and blood pressure during non-REM sleep and increases these parameters during REM sleep and wakefulness. Heart rate variability analysis, a non-invasive

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Predictors of RBD progression and conversion to synucleinopathies

Biomarkers, iRBD /

There is a variety of potential biomarkers for monitoring disease progression and predicting iRBD conversion into synucleinopathies. A combined multimodal biomarker model could offer a more sensitive and specific tool. Further longitudinal studies are warranted to iRBD as a high-risk population for early neuroprotective interventions and disease-modifying therapies. CLICK TO REVIEW

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Behavioral validation of the University of Michigan REM behavior disorder questionnaire in the synucleinopathies

iRBD /

Many questionnaires have been proposed to collect data related to dream enactment. These are typically validated by reference to objective measurements of polysomnography, which incorporate physiologic recording of muscle activity during sleep. Another approach to such questionnaire validation would be the direct behavioral observations of patients’ sleep. In the course of an ongoing study, we examined

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Polygenic burden of Parkinson’s disease risk stratifies the prognosis of isolated rapid-eye-movement disorder: A preliminary observational study

iRBD, Parkinson's Disease /

Our study showed the intriguing possibility that the disease course of iRBD patients differed according to the degree of polygenic burden of PD risk SNPs, although future validation is warranted. CLICK TO REVIEW

Polygenic burden of Parkinson’s disease risk stratifies the prognosis of isolated rapid-eye-movement disorder: A preliminary observational study Read More »

High Pesticide Exposure Events and Dream-Enacting Behaviors Among US Farmers

iRBD, Parkinson's Disease, Pesticides, Pre-PD /

Dream-enacting behavior is a characteristic feature of rapid eye movement sleep behavior disorder, the most specific prodromal marker of synucleinopathies. Pesticide exposure may be associated with dream-enacting behaviors, but epidemiological evidence is limited. This study provides the first epidemiological evidence that high pesticide exposures may be associated with a higher risk of dream-enacting behaviors. CLICK

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