Sialic acid–protein interactions are involved in regulating central nervous systemimmunity; therefore, derangements in sialylation could beinvolved in neurodegeneration. Decreased serum CDTadj is associatedwith substantia nigra degeneration in synucleinopathies.iRBD patients with low CDTadj are more likely tophenoconvert to manifest disease. CLICK TO REVIEW
We found ocular-tracking abnormalities in patients with iRBD even early in their disease progression that have not been reported before. These abnormalities are coupled with atrophy of brain areas involved in the perception of object motion and might indicate phenoconversion to synucleinopathies in iRBD. © 2022 International Parkinson and Movement Disorder Society. CLICK TO REVIEW
Background:Prodromal multiple system atrophy (MSA) has been characterized mainly by retrospective chart reviews. Direct observation and tracking of prodromal markers in MSA have been very limited Objective:To report the baseline characteristics and evolution of prodromal markers of MSA as they were prospectively measured in patients with idiopathic/isolated REM sleep behavior disorder (iRBD) Methods:Patients with iRBD were
To search for discriminating biomarkers, 30 patients with idiopathic rapid-eyemovements sleep behavior disorder (iRBD) were compared with 17 patientswith RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated a-synuclein depositsand whole-night video-polysomnography. Skin biopsy was positive for phosphorylated a-synuclein deposits in 86.7% of iRBD patients and in none
Biomarkers for REM sleep behavior disorder in idiopathic
and narcoleptic patients Read More »
Gait parameters and a pretrained statistical model can robustly distinguish participants with iRBD from HCs and patients with PD. This could be used to screen subjects with future synucleinopathies in the general population and to identify a conversion threshold to PD. CLICK TO REVIEW
RBD stands for Rapid Eye Movement Disorder and is a sleep disorder that happens duringyour REM (Rapid Eye Movement) stage of sleep. People often associate the cause of RBD with dreamsbecause people dream during the REM stage of sleep, which is also when RBD tends to happen as well.It may affect a small fraction of
Is the cause of RBD neurological or psychological? Read More »
Braak’s hypothesis has been extremely influential over the last two decades. However, neuropathological and clinical evidence suggest that the model does not conform to all patients with Parkinson’s disease (PD). To resolve this controversy, a new model was recently proposed; in brain-first PD, the initial α-synuclein pathology arise inside the central nervous system, likely rostral to
Clinical and imaging evidence of brain-first and body-first Parkinson’s disease Read More »
Current study provides a valuable and highly informative dataset of EV-associated sncRNAsfrom plasma of iRBD and PD patients. We identified miRNA signature features that could serve asminimally-invasive, blood-based surveillance biomarkers for distinguishing iRBD or PD from healthyindividuals with high sensitivity, specificity, and accuracy. CLICK TO REVIEW
ABSTRACT Although the cepstral peak prominence (CPP) and its variant, the cepstral peak prominence smooth (CPPS), are considered to be robust acoustic measures for the evaluation of dysphonia, whether they are sensitive to capture early voice changes in Parkinson’s disease (PD) has not yet been explored. This study aimed to investigate the voice changes via
Study Objectives To analyze cognitive deficits leading to unsafe driving in patients with REM Sleep Behavior Disorder (RBD), strongly associated with cognitive impairment and synucleinopathy-related neurodegeneration.Methods Twenty isolated RBD (iRBD), 10 symptomatic RBD (sRBD), and 20 age- and education-matched controls participated in a prospective case-control driving simulation study. Group mean differences were compared with correlations
Cognition and driving ability in isolated and symptomatic REM sleep behavior disorder Read More »