iRBD

Possible predictors of phenoconversion in isolated REM sleep behaviour disorder: a systematic review and meta-analysis

A-Synuclein, Biomarkers, Hyposmia, Hyposmia, iRBD, Orthostatic Hypotension /

Background A number of promising biomarkers for predicting imminent α-synucleinopathies have been suggested in isolated rapid eye movement sleep behaviour disorder (iRBD). However, existing evidence is conflicting without quantitative evaluation. Methods PubMed, Web of Science and ClinicalTrials.gov were searched through June 2021 to identify possible predictors of phenoconversion from iRBD to Parkinson’s disease (PD). The pooled HRs […]

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Disruption of Brainstem Structural Connectivity in REM Sleep Behavior Disorder Using 7 Tesla Magnetic Resonance Imaging

iRBD, Pre-PD /

BACKGROUND: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is one of the earliest manifestations of α synucleinopathies. Brainstem pathophysiology underlying REM sleep behavior disorder has been described in animal models, yet it is understudied in living humans because of the lack of an in vivo brainstem nuclei atlas and to the limited magnetic

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Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies

A-Synuclein, iRBD, Parkinson's Disease, Pre-PD /

Several studies have confirmed α-synuclein real-time quaking-induced conversion (αSyn-RTQuIC) assay to have high sensitivity and specificity for Parkinson’s disease. However, whetherthe assay can be used as a robust, quantitative measure to monitor disease progression, stratifydifferent synucleinopathies and predict disease conversion in patients with idiopathic REMsleep behaviour disorder remains undetermined. The aim of this study was

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REM sleep without atonia and vestibular-evoked myogenic potentials: Clinical brainstem dysfunction in early-stage Parkinson’s disease and isolated REM sleep behavior disorder

iRBD /

Brainstem neurophysiology as evidenced by altered VEMPs in patients with PD and iRBD could reflect disease evolvement. Moreover, VEMPs alterations may vary depending on the presence of RBD in PD patients. The associations between altered RSWA and VEMP parameters highlight the meaningfulness of detecting brainstem dysfunction in early-stage PD. Keywords Parkinson’s disease vestibular-evoked myogenic potentials

REM sleep without atonia and vestibular-evoked myogenic potentials: Clinical brainstem dysfunction in early-stage Parkinson’s disease and isolated REM sleep behavior disorder Read More »

Nocturnal Teeth Grinding Linked With Incidence of Other Sleep-Related Disorders

iRBD, Parkinson's Disease, Pre-PD /

SB is more prevalent in patients with the previously mentioned disorders than in the general population. Sleep arousal may be a common factor with which all the identified disorders are associated, except RBD and Parkinson’s disease. The associations between SB and these identified sleep-related disorders call for more SB screening in patients with the above mentioned

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Correlations with REM sleep behavior disorder severity in isolated rapid eye movement sleep behavior disorders patients

iRBD, Non-Motor Symptoms, Parkinson's Disease, Pre-PD /

Objectives: The pathogenesis of isolated rapid eye movement sleep behavior disorders (iRBD) is poorly understood. The severity of RBD may reflect its pathogenesis. Methods: We compared motor function and non-motor symptoms (NMSs) between iRBD patients and healthy volunteers. We correlated motor function, NMSs, and striatal dopaminergic activity with RBD severity using video-polysomnography. Results: Twenty-one iRBD

Correlations with REM sleep behavior disorder severity in isolated rapid eye movement sleep behavior disorders patients Read More »

Minor hallucinations in isolated rapid eye movement sleep behavior disorder indicative of early phenoconversion: A preliminary study

iRBD /

Minor hallucinations (MH) are psychotic symptoms that can occur anywhere between prodromal to early Parkinson’s disease and after onset of motor problems. MH include visual illusions, presence hallucinations, and passage hallucinations. Isolated rapid eye movement sleep behavior disorder (RBD) is a harbinger of neurodegenerative diseases. We conducted a retrospective cohort study to investigate the clinical

Minor hallucinations in isolated rapid eye movement sleep behavior disorder indicative of early phenoconversion: A preliminary study Read More »

Alerting Network Alteration in Isolated Rapid Eye Movement Sleep Behavior Disorder Patients with Mild Cognitive Impairment

iRBD /

Our findings indicate that when cognition is reduced to MCI levels in iRBD patients, the attention network, especially the alerting component, is impaired. The attention network and cognition, on the other hand, can be preserved in iRBD patients due to the compensatory mechanism. CLICK TO REVIEW Keywords REM sleep behavior disorder, Event-related potentials, Attention network

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Video-polysomnography procedures for diagnosis of rapid eye movement sleep behavior disorder (RBD) and the identification of its prodromal stages: Guidelines from the International RBD Study Group

iRBD, Pre-PD /

Video-polysomnography (v-PSG) is essential for diagnosing rapid eye movement (REM)sleep behavior disorder (RBD). Although there are current American Academy of SleepMedicine standards to diagnose RBD, several aspects need to be addressed to achieveharmonization across sleep centers. Prodromal RBD is a stage in which symptoms andsigns of evolving RBD are present, but do not yet meet

Video-polysomnography procedures for diagnosis of rapid eye movement sleep behavior disorder (RBD) and the identification of its prodromal stages: Guidelines from the International RBD Study Group Read More »