iRBD

Melatonin as first-line treatment for sleep disorders in Parkinson’s disease?

Biomarkers, iRBD, Pre-PD /

Sleep disturbance has been reported in up to 88%–98% of Parkinson’s disease patients; various sleep disorders can present even before motor symptoms. Rapid eye movement sleep behavior disorder (RBD), which can lead to violent dream enactment behavior, has a prevalence in Parkinson’s disease of 20% to 50% but best management of the condition is unclear. […]

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Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects

A-Synuclein, Genetic, iRBD, Pre-PD /

Rapid eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, isan early clinical symptom of alpha-synucleinopathies. RBD also defines more severe forms of alphasynucleinopathies. The genetic background of RBD and its underlying mechanisms are not wellunderstood. Here, we performed the first genome-wide association study of RBD, identifying five RBD riskloci. Expression

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Advances in early predictors for phenotypic transformation of idiopathic rapid eye movement sleep behavior disorder

A-Synuclein, Biomarkers, iRBD, Pre-PD /

Idiopathic rapid eye movement (REM) sleep behavior disorder is recognized as a prodromal stage of α-synucleinopathies such as Parkinson′s disease, Lewy body dementia and multiple system atrophy. It is important to timely identify early predictors that can predict early conversion into α-synucleinopathies. This review provided an update on classic and novel early predictors of α-synucleinopathies in patients with idiopathic REM sleep behavior disorder and provided a comprehensive understanding on the phenotypic transformation of the disease. CLICK TO

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Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects

A-Synuclein, iRBD /

Rapid eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, isan early clinical symptom of alpha-synucleinopathies. RBD also defines more severe forms of alphasynucleinopathies. The genetic background of RBD and its underlying mechanisms are not wellunderstood. Here, we performed the first genome-wide association study of RBD, identifying five RBD riskloci. Expression

Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects Read More »

Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder

A-Synuclein, iRBD /

Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving α-synuclein pathology, such as Parkinson’s disease, dementia with Lewy bodies, or multiple system atrophy. Abnormal α-synuclein deposition occurs early in the neurodegenerative process across the central and peripheral nervous systems and might precede the appearance of motor symptoms and cognitive decline

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Cutaneous Alpha-Synuclein is Correlated with Autonomic Impairment in Isolated REM Sleep Behavior Disorder

A-Synuclein, iRBD, Parkinson's Disease, Pre-PD /

The presence of p-syn at any biopsy site was correlated with both sympathetic (CASS adrenergic r = 0.6, p < 0.05) and total autonomic impairment (CASS total r = 0.6, p < 0.05) on autonomic reflex testing in iRBD patients. These results were independent of the density of p-syn at each site. There was no

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Retinal thickness and microvascular pathway in Idiopathic Rapid eye movement sleep Behaviour Disorder and Parkinson’s disease

iRBD, Parkinson's Disease, Pre-PD /

In PD and iRBD patients retina was thinner than HCs, and values of iRBD were between PD and HCs. Moreover, in iRBD, a peculiar microvascular pattern has been found, characterized by a higher vascularization of the deep capillary plexus. Our findings suggest that retina might be considered a biomarker of neurodegeneration in iRBD, easily estimable

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Motor Dysfunction in REM Sleep Behavior Disorder: A Rehabilitation Framework for Prodromal Synucleinopathy

A-Synuclein, Dementia - Lewy Bodies, Diet and Exercise, iRBD, Pre-PD /

The proposed rehabilitation framework for iRBD includes early exercise-based interventions of aerobic exercise, progressive resistance training, and multimodal exercise with rehabilitation consultations to address exercise prescription, progression, and monitoring. This rehabilitation framework may be used to implement neuroprotective, multidisciplinary, and proactive clinical care in people with a high likelihood of conversion to PD, dementia with

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Serum metabolic biomarkers for synucleinopathy conversion in isolated REM sleep behavior disorder

A-Synuclein, Biomarkers, iRBD, Parkinson's Disease, Pre-PD /

Our results indicate that metabolic alterations and inflammation are involved in iRBD pathophysiology, and suggest biological differences underlying the progression of LTS in iRBD patients. Our data also indicate that profiling of serum samples by NMR may be a useful tool for identifying short-term high-risk iRBD patients for conversion to parkinsonism or dementia. CLICK TO

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