iRBD

PPMI 2.0 Clinical -Establishing a Deeply Phenotyped PD Cohort (PPMI)

Biomarkers, iRBD, Symptoms / Diagnosis /

The Parkinson Progression Marker Initiative 2.0 (PPMI 2.0) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson’s disease (PD) progression in study participants with manifest PD, prodromal PD, and healthy controls The overall goal of PPMI 2.0 is to identify […]

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Autonomic disorders predicting Parkinson disease

Biomarkers, Constipation, iRBD, Pre-PD /

There is evidence that constipation, urinary and sexual dysfunction and more recently decreased cardiac chronotropic response during exercise, are part of the premotor parkinsonian phenotype. The sensitivity and specificity of these features has yet to be accurately assessed. We briefly review the evidence for autonomic dysfunction as biomarker of premotor PD. CLICK TO REVIEW

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Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder

Biomarkers, iRBD, Pre-PD /

The iRBD patients had increased classical monocytes and mature natural killer cells. Remarkably, the levels of expression of Toll-like receptor 4 (TLR4) on blood monocytes in iRBD patients were positively correlated with nigral immune activation measured by 11C-PK11195 PET and negatively correlated with putaminal 18F-DOPA uptake; the opposite was seen for the percentage of CD163+

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Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease

Biomarkers, iRBD, Parkinson's Disease, Pre-PD /

Patients diagnosed with iRBD are characterized by poor global cognitive performance, but better long-term memory and higher levels of depression, anxiety, alexithymia and apathy. Alexithymia and apathy in patients diagnosed with iRBD may be the expression of precocious derangement of emotional regulation, subsequently observed also in PD. Cognitive and neuropsychiatric symptoms of iRBD are early

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Impact of rapid eye movement sleep behavior disorder and autonomic disorders on Parkinson’s disease

Biomarkers, Dementia - Lewy Bodies, iRBD, Symptoms / Diagnosis /

This article aimed at critically reviewing the literature on the controversies about the prevalence of RBD in PD, the higher incidence of PD non-motor symptoms associated with RBD, the evidence of faster motor worsening in parkinsonian patients with this parasomnia, and the main pathophysiological hypotheses that support these findings. CLICK TO REVIEW

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Prefrontal network dysfunctions in rapid eye movement sleep behavior disorder

A-Synuclein, iRBD, Pre-PD /

We found abnormal ECN and normal DMN as a possible hallmark of cognitive dysfunctions in early α-synucleinopathies. We replicated abnormalities in BGN and SMN corresponding to subclinical movement disorder of RBD. RsfcMRI may provide an early biomarker of both cognitive and motor network dysfunctions of α-synucleinopathies. CLICK TO REVIEW

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Altered Functional Connectivity Between Insula and Precuneus in Isolated REM Sleep Behavior Disorder

Biomarkers, iRBD /

Connectivity between the insula and precuneus may be associated with cognitive function among patients with isolated rapid eye movement sleep behavior disorder (iRBD), according to the results of a cross-sectional study published in Sleep Medicine. Study researchers recruited patients (n=50) diagnosed by video-polysomnography with iRBD at Seoul National University Hospital Sleep Clinic and healthy controls (n=20)

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CSF Biomarker Flags Parkinson’s Pathology Years Before Symptoms Appear

A-Synuclein, Biomarkers, iRBD, Pre-PD, Vagal Nerve /

Real-time quaking-induced conversion (RT-QuIC), a test for pathological misfolded protein, detected alpha-synuclein in the cerebrospinal fluid (CSF) of patients with isolated rapid-eye-movement (REM) sleep behavior disorder (IRBD), years before clinical symptoms of Parkinson’s disease or dementia with Lewy bodies emerged. In these patients, RT-QuIC detected misfolded alpha-synuclein in CSF with both sensitivity and specificity of

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Study reveals close link between Parkinson’s disease and certain immune cells in the blood

Biomarkers, Dementia - Lewy Bodies, iRBD, Pre-PD /

The researchers have studied a group of patients suffering from REM Sleep Behavior Disorder (RBD), a condition where the patients physically act vivid dreams with vocalizations and movements. If a patient e.g. dreams that they are running, their legs will move as if they were actually running. The sleep disorder is often discovered by a

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Probable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson’s disease

Biomarkers, iRBD, Pre-PD /

These results support the idea that RBD is an important marker of rapid progression in PD motor and non-motor symptoms and suggest that the atrophy in the left insula and caudate nucleus might be the underlying neurobiological mechanisms of the poorer prognosis in PD patients with RBD. CLICK TO REVIEW

Probable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson’s disease Read More »