iRBD

Spectrum of Non-Motor Symptoms in Parkinson’s Disease

A-Synuclein, Biomarkers, Gut Dysbiosis, iRBD, Olfactory, Pre-PD /

Parkinson’s disease is predominantly classified as a movement disorder. Beyond the textbook definition of rigidity, tremors, and bradykinesia, Parkinson’s disease encompasses an entire entity of non-motor symptom complexes that can precede the motor features by many years. Despite their significant clinical importance, the awareness of non-motor symptoms is quite negligible. Sleep disorders, gastrointestinal dysfunction, olfactory […]

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PREMOTOR PARKINSON’S DISEASE: OVERVIEW OF CLINICAL SYMPTOMS AND CURRENT DIAGNOSTIC METHODS

Biomarkers, iRBD, Pre-PD, Symptoms / Diagnosis /

The best known premotor symptoms include hyposmia, REM sleep behavior disorder (RBD), constipation, and depression; other symptoms are excessive daytime somnolence, orthostatic hypotension and symptomatic hypotension, erectile or urinary dysfunction, musculoskeletal symptoms, pain, and global cognitive deficit. In this review, we summarize currently available diagnostic methods for these symptoms. We also briefly summarize neuroimaging, polyneuropathy,

PREMOTOR PARKINSON’S DISEASE: OVERVIEW OF CLINICAL SYMPTOMS AND CURRENT DIAGNOSTIC METHODS Read More »

Olfactory impairment as an early marker of Parkinson’s disease in REM sleep behavior disorder: a systematic review and meta-analysis

Biomarkers, iRBD, Olfactory /

We identified similar olfactory impairments in patients with RBD and patients with PD (either with or without underlying RBD). These findings suggest that olfactory impairment may be a sensitive and stable diagnostic biomarker of RBD and appears to be useful for identifying patients with idiopathic RBD at high risk for early conversion to PD. CLICK

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A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice

iRBD /

During rapid eye movement (REM) sleep, anti-gravity muscle tone and bodily movements are mostly absent, because somatic motoneurons are inhibited by descending inhibitory pathways. Recent studies showed that glycine/GABA neurons in the ventromedial medulla (VMM) (GlyVMM neurons) play an important role in generating muscle atonia during REM sleep (REM-atonia). CLICK TO REVIEW

A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice Read More »

α-Synuclein Responses: Implications for Early Appearance of Sleep Disorders in Parkinson’s Disease

iRBD, Library, Parkinson's Disease /

Sleep Disorders (SDs) precede motor symptoms of Parkinson’s disease (PD), suggesting an early effect of disease processes on sleep control neurons.  These nucleus-specific differential effects suggest previously unappreciated, mechanistic underpinnings of SDs’ prodromal PD appearance in PD, and wehypothesize that in the prodromal phase of PD, the early form of α-synuclein compromises sleep-control neurons. https://doi.org/10.21203/rs.3.rs-134060/v1

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Hypomethylation of SNCA in Idiopathic REM Sleep Behavior Disorder Associated With Phenoconversion

iRBD, Library /

Background Hypomethylation of intron 1 of the α‐synuclein (SNCA) gene has been extensively reported in the blood of patients with α‐synucleinopathies. Idiopathic rapid eye movement sleep behavior disorder represents a prodromal stage of α‐synucleinopathies. Methylation of α‐synuclein intron 1 in idiopathic rapid eye movement sleep behavior disorder patients is largely unexplored. The objective of the

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