Iron

Iron Neurotoxicity in Parkinson’s Disease

Iron /

Iron plays essential roles in the early development of cognitive processes and in the maintenance of neuronal functions in the mature brain; therefore, neurons have expeditious mechanisms to ensure a readily available iron supply. However, several neurodegenerative diseases present dysregulation of iron homeostasis derived from mitochondrial dysfunction, inflammatory conditions, decreased glutathione levels, and oxidative damage, […]

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Calcium channels and iron metabolism: A redox catastrophe in Parkinson’s disease and an innovative path to novel therapies?

Iron, Parkinson's Disease, Pre-PD /

Autonomously spiking dopaminergic neurons of the substantia nigra pars compacta (SNpc) are exquisitely specialized and suffer toxic iron-loading in Parkinson’s disease (PD). However, the molecular mechanism involved remains unclear and critical to decipher for designing new PD therapeutics. The long-lasting (L-type) CaV1.3 voltage-gated calcium channel is expressed at high levels amongst nigral neurons of the

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Metals associated neurodegeneration in Parkinson’s disease: Insight to physiological, pathological mechanisms and management

A-Synuclein, Dementia - Lewy Bodies, Iron, Parkinson's Disease, Pre-PD /

 There is increasing evidence that heavy metals normally present in the human body in minute concentration also cause accumulation to initiate the free radical formation and affecting the basal ganglia signaling. In this review, we explored how these metals affect brain physiology and their roles in the accumulation of toxic proteins (α-synuclein and Lewy bodies).

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Is Chelation Therapy a Potential Treatment for Parkinson’s Disease

Iron, Parkinson's Disease /

The current use of chelators in clinical medicine is presented together with a discussion of two clinical trials of PD patients where an iron chelator was administered and showed encouraging results. It is proposed that the use of anti-inflammatory drugs combined with an iron chelator might be a better approach to increase chelator efficacy. CLICK

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Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson’s Disease

A-Synuclein, Fecal Transplants (FMT), Iron, Pre-PD /

We argue that there is significant evidence that bacterial inflammagens fuel this systemic inflammation, and might be central to thedevelopment of PD. We also discuss the processes whereby bacterial inflammagens may be involved in causing nucleation of proteins, including of α-Syn. Lastly, we review evidence that iron chelation, pre-and probiotics, as well as antibiotics and

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Effect of 8-Day Fasting on Leukocytes Expression of Genes and Proteins Involved in Iron Metabolism in Healthy Men

Fasting, Iron /

Eight days of total starvation diet affected the body composition and decreased exercise capacity. Further, fasting decreased the expression of genes associated with iron storage and export, and increased the expression of genes involved in iron acquisition. Conversely, only PCBP2 protein increased after fasting; however, an upward trend was apparent for all proteins. In conclusion,

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Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease

Iron, Parkinson's Disease, Pre-PD /

The highest cellular iron levels in neurons were located in the cytoplasm, which might increase the source of non-chelated Fe3+, implicating a critical increase in the labile iron pool. Indeed, neuromelanin is characterized by a significantly higher loading of iron including most probable the occupancy of low-affinity iron binding sites. Quantitative trace element analysis is

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“Metal elements and pesticides as risk factors for Parkinson’s disease – A review”

Biomarkers, Iron, Pesticides /

This review provides an outline of our current knowledge on the possible association between metals and PD. We have discussed the potential association between these two, furthermore the chemical properties, biological and toxicological aspects as well as possible mechanisms of Fe, Mn, Cu, Zn, Al, Ca, Pb, Hg and Zn in PD pathogenesis. In addition,

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Novel targeted therapies for Parkinson’s disease

A-Synuclein, Biomarkers, Iron, Pre-PD /

Large biomarker development programs are undertaken to identify disease signatures that will improve patient selection and outcome measures in clinical trials. In this review, we summarize PD-related mechanisms that can serve as targets of therapeutic interventions aiming to slow or modify disease progression, as well as previous and ongoing clinical trials in each field, and

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