Metabolites

Western and ketogenic diets in neurological disorders: can you tell the difference?

Diet and Exercise, Metabolites, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

The prevalence of obesity tripled worldwide between 1975 and 2016, and it is projected that half of the US population will be overweight by 2030. The obesity pandemic is attributed, in part, to the increasing consumption of the high-fat, high-carbohydrate Western diet, which predisposes to the development of the metabolic syndrome and correlates with decreased […]

Western and ketogenic diets in neurological disorders: can you tell the difference? Read More »

Environmental factors shaping the gut microbiome in a Dutch population

Diet and Exercise, Enviromental, Gut Dysbiosis, Gut Microbiota, Metabolites, Parkinson's Disease /

The gut microbiome is associated with diverse diseases1,2,3, but a universal signature of a healthy or unhealthy microbiome has not been identified, and there is a need to understand how genetics, exposome, lifestyle and diet shape the microbiome in health and disease. Here we profiled bacterial composition, function, antibiotic resistance and virulence factors in the

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Fermented Foods, Health and the Gut Microbiome

Fermented Foods, Gut Microbiota, Metabolites, Probiotics, Prebiotics and Symbiotics /

Fermented foods have been a part of human diet for almost 10,000 years, and their levelof diversity in the 21st century is substantial. The health benefits of fermented foods have beenintensively investigated; identification of bioactive peptides and microbial metabolites in fermentedfoods that can positively affect human health has consolidated this interest. Each fermented foodtypically hosts

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Gut–Brain Cross Talk: Microbiome
and Micronutrients

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Metabolites, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

A good diet may deliver micronutrients such as vitamins A, B6, B12, C,and D and minerals such as iron, copper, zinc, and selenium that have beenimplicated to have key roles for supporting immunity with reducing host infections.Most studies have shown that once the subject was infected, the immune system willbe enhanced, which will require high

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and Micronutrients Read More »

Is the Use of Glyphosate in Modern Agriculture Resulting in Increased Neuropsychiatric Conditions Through Modulation of the Gut-brain-microbiome Axis?

Enviromental, Glyphosate, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Metabolites, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Environmental exposure to glyphosate and glyphosate-based herbicides has the potential to negatively influence neurodevelopment and behavior across generations indirectly through the gut-brain-microbiome axis. Potential mechanisms by which glyphosate may elicit these effects are through the disruption of the normally symbiotic relationship of the host and the gut microbiome. Given glyphosate can kill commensal members of

Is the Use of Glyphosate in Modern Agriculture Resulting in Increased Neuropsychiatric Conditions Through Modulation of the Gut-brain-microbiome Axis? Read More »

Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate

Butyrate, Gut Dysbiosis, Gut Microbiota, Lipopolysaccharides (LPS), Metabolites, Short Chain Fatty Acids /

Our data indicate a cause–effect relationship between gut microbiota and PSCI for the first time, which is likely mediated by inflammation-regulating metabolites including LPS and butyrate. CLICK TO REVIEW

Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate Read More »

Positive Interventional Effect of Engineered Butyrate-Producing
Bacteria on Metabolic Disorders and Intestinal Flora Disruption
in Obese Mice

Butyrate, Metabolites, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The substantially increased prevalence of obesity and obesity-relateddiseases has generated considerable concern. Currently, synthetic biological strategieshave played an essential role in preventing and treating chronic diseases such as obesity.A growing number of symbiotic bacteria used as vectors for genetic engineering havebeen applied to create living therapeutics. In this study, using Bacillus subtilis as a cellularchassis,

Positive Interventional Effect of Engineered Butyrate-Producing
Bacteria on Metabolic Disorders and Intestinal Flora Disruption
in Obese Mice Read More »

Periodontal Pathogens as Risk Factors of Cardiovascular Diseases, Diabetes, Rheumatoid Arthritis, Cancer, and Chronic Obstructive Pulmonary Disease—Is There Cause for Consideration?

Butyrate, Metabolites, Oral Microbiome, Periodontitis, Short Chain Fatty Acids /

Cardiovascular diseases, chronic obstructive pulmonary diseases, diabetes, rheumatoid arthritis, and cancer are the most common noncommunicable diseases (NCDs). These NCDs share risk factors with periodontal disease (PD), a preventable risk factor linked to lifestyle. The discussion regarding the association between these chronic diseases is more complex. There is still a significant knowledge gap particularly of

Periodontal Pathogens as Risk Factors of Cardiovascular Diseases, Diabetes, Rheumatoid Arthritis, Cancer, and Chronic Obstructive Pulmonary Disease—Is There Cause for Consideration? Read More »

A metabolic biomarker predicts Parkinson’s disease at the early stages in patients and animal models

Biomarkers, Metabolites, Parkinson's Disease, Pre-PD /

Care management of Parkinson’s disease (PD) patients currently remains symptomatic, mainly because diagnosis relying on the expression of the cardinal motor symptoms is made too late. Earlier detection of PD therefore represents a key step for developing therapies able to delay or slow down its progression. From our translational study, which included 3 animal models

A metabolic biomarker predicts Parkinson’s disease at the early stages in patients and animal models Read More »

Molecular Docking Studies of Secondary Metabolites against Sequestosome-1 to Treat Parkinson Disease

Metabolites, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is one of the major progressive neurological disorders. It occurs due to a low level of achemical substance in the brain known as Dopamine, which controls the muscle movements of the body. In many cases, PDoccurs due to a low level of dopamine. PD generally appears in persons between the ages of

Molecular Docking Studies of Secondary Metabolites against Sequestosome-1 to Treat Parkinson Disease Read More »