Metabolites

Potential Role of Akkermansia muciniphila in Parkinson’s Disease and Other Neurological/Autoimmune Diseases

Gut Microbiota, Metabolites, Probiotics, Prebiotics and Symbiotics /

The composition of the gut microbiota, including Akkermansia muciniphila (A. muciniphila), is altered in many neurological diseases and may be involved in the pathophysiological processes of Parkinson’s disease (PD). A. muciniphila, a mucin-degrading bacterium, is a potential next-generation microbe that has anti-inflammatory properties and is responsible for keeping the body healthy. As the role of A. muciniphila in PD has […]

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Modeling approaches for probing cross-feeding interactions in the human gut microbiome

Gut Microbiota, Metabolites, Parkinson's Disease, Short Chain Fatty Acids /

Microbial communities perform emergent activities that are essentially different from those carried by their individual members. The gut microbiome and its metabolites have a significant impact on the host, contributing to homeostasis or disease. Food molecules shape this community, being fermented through cross-feeding interactions of metabolites such as lactate, acetate, and amino acids, or products derived from macromolecule degradation. Mathematical and

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Review of Metabolomics-Based Biomarker Research for Parkinson’s Disease

Biomarkers, Metabolites, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD), as the second most common neurodegenerative disease, is seriously affecting the life quality of the elderly. However, there is still a lack of efficient medical methods to diagnosis PD before apparent symptoms occur. In recent years, clinical biomarkers including genetic, imaging, and tissue markers have exhibited remarkable benefits in assisting PD diagnoses.

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The Role of Dysbiosis in Neurological Disorders

Biomarkers, Butyrate, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Metabolites, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The gut brain axis is a system of bi-directional communication. When the delicate balance of the microbiome is disrupted, the resulting dysbiosis can be a factor in the development of neurological disorders, including Alzheimer’s Disease (AD), Parkinson’s Disease (PK), and Multiple Sclerosis (MS). One major player in the gut brain axis are short-chain fatty acids

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The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

Anti-oxidants, Constipation, Diet and Exercise, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Metabolites, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The fact that millions of people worldwide suffer from Alzheimer’s disease (AD) orParkinson’s disease (PD), the two most prevalent neurodegenerative diseases (NDs), has beena permanent challenge to science. New tools were developed over the past two decades andwere immediately incorporated into routines in many laboratories, but the most valuable scientificcontribution was the “waking up” of

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A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Metabolites /

The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This review will make the case for oxygen-dependent metabolism of hydrogen sulfide (H2S) and polysulfides, collectively referred to as reactive sulfur species (RSS)

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Oral, nasal, and gut microbiota in Parkinson’s disease

Gut Dysbiosis, Gut Microbiota, Metabolites, Oral Microbiome /

Parkinson’s disease (PD) is the second most frequently diagnosed neurodegenerative disease. The purpose of this study was to investigate the link between microbiota composition in important mucosal interfaces (oral, nasal, and intestinal) and PD. Sequencing was undertaken of the V4–V5 region of the 16S ribosomal RNA (rRNA) gene of the microbiome from the oral cavity,

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Investigating Casual Associations among Gut Microbiota, Metabolites and Neurodegenerative Diseases: A Mendelian Randomization Study

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Metabolites, Parkinson's Disease /

Our study firstly applied a two-sample MR approach to detect causal relationships among gut microbiota, gut metabolites and the risk of AD, PD and ALS, andwe revealed several causal relationships. These findings may provide new targets for treatment of these neurodegenerative diseases, and may offer valuableinsights for further researches on the underlying mechanisms. In summary,

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The Effect of a Probiotic Complex on the Gut-Brain Axis: A Translational Study

Biomarkers, Gut Microbiota, Metabolites, Probiotics, Prebiotics and Symbiotics /

A significant improvement of cognitive functions, in terms of short-termmemory, attention, and executive performance, as well as ofpsychophysiological markers, such as salivary cortisol level,skin conductance, sleep quality, and anxiety, were observed.Conclusions: According to the results, L. reuteri PBS072 andB. breve BB077 are potential probiotic candidates for improving stress resilience, cognitive functions, and sleep quality CLICK

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Desulfovibrio Bacteria Are Associated With Parkinson’s Disease

Biomarkers, Gut Dysbiosis, Gut Microbiota, Hydrogen, Metabolites, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is the most prevalent movement disorder known and predominantly affects the elderly. It is a progressive neurodegenerative disease wherein α-synuclein, a neuronal protein, aggregates to form toxic structures in nerve cells. The cause of Parkinson’s disease (PD) remains unknown. Intestinal dysfunction and changes in the gut microbiota, common symptoms of PD, are

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