Mitochondria

How microcompetition with latent viruses can cause α synuclein aggregation, mitochondrial dysfunction, and eventually Parkinson’s disease

A-Synuclein, Mitochondria, Viral / Bacterial Infections /

The cause of most Parkinson’s disease cases is unknown. However, it is well documented that mitochondrial dysfunction and misfolded α synuclein aggregation are important cellular abnormalities associated with the disease. In this paper, we use the microcompetition model to show how latent viruses, which infect the central and peripheral nervous systems, can cause the observed mitochondrial dysfunction […]

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Pathophysiology of Parkinson’s disease:
Mitochondria, alpha-synuclein and much more. . .

A-Synuclein, Gut-Brain axis, Mitochondria /

ABSTRACT: Here, we give an overview of the progress that has been made over the past four decades in our understanding of this disorder. We review the role of mitochondria, environmental toxicants, alpha-synuclein and neuroinflammation in the development of PD. We also discuss more recent data from genetics, which strongly support the endosomal-lysosomal pathways and

Pathophysiology of Parkinson’s disease:
Mitochondria, alpha-synuclein and much more. . . Read More »

Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases

Diet and Exercise, Library, Mitochondria /

We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases. CLICK TO REVIEW

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