Non-Motor Symptoms

Heterogeneous digital biomarker integration out-performs patient self-reports in predicting Parkinson’s disease

Biomarkers, Non-Motor Symptoms, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is one of the first diseases where digital biomarkers demonstrated excellent performance in differentiating disease from healthy individuals. However, no study has systematically compared and leveraged multiple types of digital biomarkers to predict PD. Particularly, machine learning works on the fine-motor skills of PD are limited. Here, we developed deep learning methods […]

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Mining imaging and clinical data with machine learning approaches for the diagnosis and early detection of Parkinson’s disease

Biomarkers, Non-Motor Symptoms, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is a common, progressive, and currently incurable neurodegenerative movement disorder. The diagnosis of PD is challenging, especially in the differential diagnosis of parkinsonism and in early PD detection. Due to the advantages of machine learning such as learning complex data patterns and making inferences for individuals, machine-learning techniques have been increasingly applied

Mining imaging and clinical data with machine learning approaches for the diagnosis and early detection of Parkinson’s disease Read More »

Clinical and imaging evidence of brain-first and body-first Parkinson’s disease

A-Synuclein, Autonmic nervous system, Constipation, ENS, Gut Dysbiosis, iRBD, Non-Motor Symptoms, Orthostatic Hypotension, Parkinson's Disease, Pre-PD /

Braak’s hypothesis has been extremely influential over the last two decades. However, neuropathological and clinical evidence suggest that the model does not conform to all patients with Parkinson’s disease (PD). To resolve this controversy, a new model was recently proposed; in brain-first PD, the initial α-synuclein pathology arise inside the central nervous system, likely rostral to

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Non-Motor Symptoms and Their Associated Factors in Parkinson’s Disease

Biomarkers, Constipation, Dreams, Non-Motor Symptoms, Orthostatic Hypotension /

Background: Parkinson’s disease is a common neurologic ailment that causes tremor and bradykinesia. The prevalenceof Parkinson’s disease is estimated to be 1–2 in 1000, affecting about 1% of the population over the age of 60 years. Theobjective of this study was to find the frequency of Non-Motor Symptoms in patients with Parkinson’s Disease (PD) andits

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Cognition and driving ability in isolated and symptomatic REM sleep behavior disorder

iRBD, Non-Motor Symptoms /

Study Objectives To analyze cognitive deficits leading to unsafe driving in patients with REM Sleep Behavior Disorder (RBD), strongly associated with cognitive impairment and synucleinopathy-related neurodegeneration.Methods Twenty isolated RBD (iRBD), 10 symptomatic RBD (sRBD), and 20 age- and education-matched controls participated in a prospective case-control driving simulation study. Group mean differences were compared with correlations

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From the intestinal mucosal barrier to the enteric neuromuscular compartment: An integrated overview on the morphological changes in Parkinson’s disease

Gut Dysbiosis, Gut Microbiota, Non-Motor Symptoms /

Gastrointestinal dysfunctions represent the most common non-motor symptoms in Parkinson’s disease (PD). Ofnote, changes in gut microbiota, impairments of intestinal epithelial barrier (IEB), bowel inflammation and neuroplastic rearrangements of the enteric nervous system (ENS) could be involved in the pathophysiology of theintestinal disturbances in PD. In this context, although several review articles have pooled together

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Correlations with REM sleep behavior disorder severity in isolated rapid eye movement sleep behavior disorders patients

iRBD, Non-Motor Symptoms, Parkinson's Disease, Pre-PD /

Objectives: The pathogenesis of isolated rapid eye movement sleep behavior disorders (iRBD) is poorly understood. The severity of RBD may reflect its pathogenesis. Methods: We compared motor function and non-motor symptoms (NMSs) between iRBD patients and healthy volunteers. We correlated motor function, NMSs, and striatal dopaminergic activity with RBD severity using video-polysomnography. Results: Twenty-one iRBD

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Bioactive lipids and their metabolism: new therapeutic opportunities for Parkinson’s disease

A-Synuclein, Dementia - Lewy Bodies, Non-Motor Symptoms, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is a neurological disorder characterized by motor dysfunction, which can also be associated with non-motor symptoms. Its pathogenesis is thought to stem from a loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of Lewy bodies containing aggregated α-synuclein. Recent works suggested that lipids might play a pivotal

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Orthostatic Hypotension: JACC State-of-the-Art Review

Autonmic nervous system, Non-Motor Symptoms, Orthostatic Hypotension, Parkinson's Disease, Pre-PD /

Neurogenic orthostatic hypotension is a highly prevalent and disabling feature of autonomic failure due to both peripheral and central neurodegenerative diseases. Community-based epidemiological studies have demonstrated a high morbidity and mortality associated with neurogenic orthostatic hypotension. It is due to impairment of baroreflex-mediated vasoconstriction of the skeletal muscle and splanchnic circulation and is caused by damage

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Gastrointestinal Dysfunction in Parkinson’s Disease

Gut Dysbiosis, Gut Microbiota, Non-Motor Symptoms, Oral Microbiome /

Gastrointestinal dysfunction is a prominent nonmotor feature of Parkinson’s disease and dysfunction can be found along the entire length of the gastrointestinal tract. The enteric nervous system is clearly involved in Parkinson’s disease. Whether it is the initial source of pathology is still a source of controversy. There also is growing recognition of the role

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