Oral Microbiome

Oral ingestion of the environmental toxicant trichlorethylene in
rats induces alterations in the gut microbiome: relevance to
idiopathic Parkinson’s disease

A-Synuclein, Enviromental, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Oral Microbiome, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Microbial alterations within the gut microbiome appear to be a common feature of individuals with Parkinson’sdisease (PD), providing further evidence for the role of the gut-brain axis in PD development. As a major site ofcontact with the environment, questions have emerged surrounding the cause and effect of alterations to the gutmicrobiome by environmental contaminants associated […]

Oral ingestion of the environmental toxicant trichlorethylene in
rats induces alterations in the gut microbiome: relevance to
idiopathic Parkinson’s disease Read More »

Gut- and oral-dysbiosis differentially impact spinal- and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset

Gut Dysbiosis, Gut Permeability / Leaky Gut, Oral Microbiome /

We found increasing gut-dysbiosis with worsening symptoms in sALS patients and increasing oral-dysbiosis with worsening symptoms in bALS patients. Our findings support distinct microbial mechanisms underlying two ALS subtypes, which have been previously grouped together as a single disease. Our study suggests correcting gut-dysbiosis as a therapeutic strategy for sALS patients and correcting oral-dysbiosis as

Gut- and oral-dysbiosis differentially impact spinal- and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset Read More »

Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9-producing CD4+ T cells

Gut Dysbiosis, Gut Microbiota, Oral Microbiome /

Background Recent epidemiological studies have shown that inflammatory bowel disease is associated with periodontal disease. The oral-gut microbiota axis is a potential mechanism intersecting the two diseases. Porphyromonas gingivalis is currently considered a keystone oral pathogen involved in periodontal disease pathogenesis and disease progression. Recent studies have shown that oral ingestion of P. gingivalis leads to intestinal inflammation. However,

Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9-producing CD4+ T cells Read More »

A Review of Literature on the Relationship Between
Oral Microbiota and Rheumatoid Arthritis

Oral Microbiome, Periodontitis /

Periodontal disease (PDD) and rheumatoid arthritis (RMA) share comparative pathophysiological pathways like ongoingaggravation with resorption of the proximal bone in immunologically delicate hosts; However, PDD has a notable bacteriological etiology, and the cause of RMA remains unknown. According to some reports, an infectious agent in a vulnerable host may be the cause of RMA and

A Review of Literature on the Relationship Between
Oral Microbiota and Rheumatoid Arthritis Read More »

Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration

A-Synuclein, Gut Dysbiosis, Gut Microbiota, Lipopolysaccharides (LPS), Oral Microbiome, Parkinson's Disease, Pre-PD /

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Creutzfeldt–Jakob disease (CJD) are brain conditions affecting millions of people worldwide. These diseases are associated with the presence of amyloid-β (Aβ), alpha synuclein (α-Syn) and prion protein (PrP) depositions in the brain, respectively, which lead to synaptic disconnection and subsequent progressive neuronal death. Although

Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration Read More »

Gingival Crevicular Fluid as Biomarker’s Source for Alzheimer’s Disease

Oral Microbiome, Parkinson's Disease, Periodontitis, Pre-PD, Root Canal /

Periodontitis is a low-grade inflammatory disease caused by a subgingivaldysbiotic microbiota. Multiple studies have determined the higher prevalence of toothloss and poor oral hygiene in patients with Alzheimer’s disease (AD). However, theperiodontal diagnosis, periodontal bacteria or mediators has not been measuredto date. Aim: To determine the periodontal status, the pro-inflammatory mediators,Porphyromonas gingivalis load, and Apoliporpotein

Gingival Crevicular Fluid as Biomarker’s Source for Alzheimer’s Disease Read More »

Gastrointestinal Dysfunction in Parkinson’s Disease

Gut Dysbiosis, Gut Microbiota, Non-Motor Symptoms, Oral Microbiome /

Gastrointestinal dysfunction is a prominent nonmotor feature of Parkinson’s disease and dysfunction can be found along the entire length of the gastrointestinal tract. The enteric nervous system is clearly involved in Parkinson’s disease. Whether it is the initial source of pathology is still a source of controversy. There also is growing recognition of the role

Gastrointestinal Dysfunction in Parkinson’s Disease Read More »

Gastrointestinal dysfunction in Parkinson’s disease.

A-Synuclein, Constipation, Gut Dysbiosis, Gut Microbiota, Oral Microbiome /

Our understanding of dysfunction of the gastrointestinal system in patients with Parkinson’s disease has increased substantially in the past decade. The entire gastrointestinal tract is affected in these patients, causing complications that range from oral issues, including drooling and swallowing problems, to delays in gastric emptying and constipation. Additionally, small intestinal bacterial overgrowth and Helicobacter

Gastrointestinal dysfunction in Parkinson’s disease. Read More »

Caries and periodontal disease in patients with Parkinson’s disease

Oral Microbiome, Periodontitis /

Parkinson’s disease (PD) has been associated with aging, reduced fine motor skills, and malnutrition caused by eating soft sticky foods and a decreased liquid intake, which may contribute to the onset of caries, periodontal disease, and tooth loss. The objective of this study was to investigate the oral health of 101 patients with PD (mean

Caries and periodontal disease in patients with Parkinson’s disease Read More »

Clinical evaluation of the periodontal health condition and oral health awareness in Parkinson’s disease patients

endondonics, Oral Microbiome, Parkinson's Disease, Periodontitis, Pre-PD /

Objective and background The objectives were to compare periodontal status between subjects with and without Parkinson’s disease (PKD) to determine the influence of PKD on periodontal disease. This study was conducted to evaluate the relationship of periodontal status with severity of PKD. Conclusion There is a need for dental care and encouragement to use plaque

Clinical evaluation of the periodontal health condition and oral health awareness in Parkinson’s disease patients Read More »