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Predictors of RBD progression and conversion to synucleinopathies

Biomarkers, iRBD /

There is a variety of potential biomarkers for monitoring disease progression and predicting iRBD conversion into synucleinopathies. A combined multimodal biomarker model could offer a more sensitive and specific tool. Further longitudinal studies are warranted to iRBD as a high-risk population for early neuroprotective interventions and disease-modifying therapies. CLICK TO REVIEW

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ORAL BUTYRATE AND MICROBIOTA-TARGETED TREATMENTS FOR PARKINSON’S
DISEASE: EFFICACY STUDIES IN TRANSGENIC MICE.

A-Synuclein, Biomarkers, Butyrate, Gut Microbiota, Gut-Brain axis, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Current pharmacological treatments for Parkinson’s disease (PD) provide relief for motorsymptoms but fail to alleviate prevalent non-motor symptoms (NMS)- such as gastrointestinal(GI) dysfunction which often occurs before the development of motor symptoms. Strategies toslow the progression of PD have been proposed, but so far none has proven successful. PDpatients display changes in gut microbiome composition

ORAL BUTYRATE AND MICROBIOTA-TARGETED TREATMENTS FOR PARKINSON’S
DISEASE: EFFICACY STUDIES IN TRANSGENIC MICE. Read More »

Probiotic Bacillus subtilis
Protects against a-Synuclein
Aggregation in C. elegans

A-Synuclein, Butyrate, Gut Dysbiosis, Probiotics, Prebiotics and Symbiotics /

Recent discoveries have implicated the gut microbiome in the progression and severity of Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits a-synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans model of synucleinopathy. This protection is seen in

Probiotic Bacillus subtilis
Protects against a-Synuclein
Aggregation in C. elegans Read More »

The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: a randomized controlled trial

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Our findings support a mediating role of the gut microbiome in the beneficial effects of the Green-MED diet enriched with Mankai and green tea on cardiometabolic risk factors. CLICK TO REVIEW

The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: a randomized controlled trial Read More »

Impact of Probiotic and Prebiotic on Gut Microbiota in Pre-diabetes and Type 2 Diabetes

Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The increased worldwide prevalence of pre-diabetes and diabetes, especially type 2 diabetes, requiring different strategies for their prevention and management. A new focus is the reversal of diabetes dysbiosis, a disruption of gut microbiota homeostasis, which is closely related to elevated blood glucose levels and altered metabolic parameters. In this sense, a balanced diet plays a key role, and,

Impact of Probiotic and Prebiotic on Gut Microbiota in Pre-diabetes and Type 2 Diabetes Read More »

Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options

Butyrate, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The global incidence of numerous immune-mediated, metabolic, neurodegenerative, and psychiatric diseases is steadily increasing [1,2,3]. The increased morbidity of human populations makes them more vulnerable to additional burdens, including infectious diseases. For example, the mortality rate of diabetics infected with the original variant of the SARS Co-2 virus was about twice that of the general

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Inflammation and immune dysfunction in Parkinson disease

Gut Microbiota, Parkinson's Disease, Pre-PD /

Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral organs as well as the central nervous system and involves a fundamental role of neuroinflammation in its pathophysiology. Neurohistological and neuroimaging studies support the presence of ongoing and end-stage neuroinflammatory processes in PD. Moreover, numerous studies of peripheral blood and cerebrospinal fluid from patients

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Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS

Gut Microbiota, Gut-Brain axis /

The recent revelation that the gut microbiome, home to approximately 100 trillion microorganisms, is implicated in the development of both health and disease has spurred an exponential increase in interdisciplinary research involving gut microbiology. In all this hype, there is a need to better understand and contextualize the emerging evidence for the role of the gut microbiota in

Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS Read More »

Behavioral validation of the University of Michigan REM behavior disorder questionnaire in the synucleinopathies

iRBD /

Many questionnaires have been proposed to collect data related to dream enactment. These are typically validated by reference to objective measurements of polysomnography, which incorporate physiologic recording of muscle activity during sleep. Another approach to such questionnaire validation would be the direct behavioral observations of patients’ sleep. In the course of an ongoing study, we examined

Behavioral validation of the University of Michigan REM behavior disorder questionnaire in the synucleinopathies Read More »

Intertwined Relationship of Mitochondrial Metabolism, Gut
Microbiome and Exercise Potential

Gut Microbiota, Mitochondria /

: The microbiome has emerged as a key player contributing significantly to the humanphysiology over the past decades. The potential microbial niche is largely unexplored in the contextof exercise enhancing capacity and the related mitochondrial functions. Physical exercise can influence the gut microbiota composition and diversity, whereas a sedentary lifestyle in association withdysbiosis can lead

Intertwined Relationship of Mitochondrial Metabolism, Gut
Microbiome and Exercise Potential Read More »