Library

α-Synuclein in Parkinson’s disease and advances in detection

A-Synuclein, Biomarkers, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is a threatening neurodegenerative disorder that seriously affects patients’ life quality. Substantial evidence links the overexpression and abnormal aggregation of alpha-synuclein (α-Syn) to PD. α-Syn has been identified as a characteristic biomarker of PD, which indicates its great value of diagnosis and designing effective therapeutic strategy. This article systematically summarizes the pathogenic […]

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Characteristics of gut microbiome, organic acid profiles and viral antibody indexes of
healthy Japanese with live Lacticaseibacillus detected in stool

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Probiotics, Prebiotics and Symbiotics /

To estimate the health-promoting effects of Lacticaseibacillus paracasei (previously Lactobacillus casei) strainShirota (LcS) that reached the lower gastrointestinal tract alive, we investigated the characteristics of gut microbiome,organic acid profiles, defecatory symptoms and serum viral antibody indexes of healthy Japanese adults between thegroup in whom live LcS was detected or not from stool. The β-diversity index

Characteristics of gut microbiome, organic acid profiles and viral antibody indexes of
healthy Japanese with live Lacticaseibacillus detected in stool Read More »

Plasma Metabolite Signature Classifies Male LRRK2 Parkinson’s Disease Patients

Autophagy, Biomarkers, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is a progressive neurodegenerative disease, causing loss of motor and nonmotor function. Diagnosis is based on clinical symptoms that do not develop until late in the disease progression, at which point the majority of the patients’ dopaminergic neurons are already destroyed. While many PD cases are idiopathic, hereditable genetic risks have been

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Heterogeneous digital biomarker integration out-performs patient self-reports in predicting Parkinson’s disease

Biomarkers, Non-Motor Symptoms, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is one of the first diseases where digital biomarkers demonstrated excellent performance in differentiating disease from healthy individuals. However, no study has systematically compared and leveraged multiple types of digital biomarkers to predict PD. Particularly, machine learning works on the fine-motor skills of PD are limited. Here, we developed deep learning methods

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Increased Transferrin Sialylation Predicts Phenoconversion in
Isolated REM Sleep Behavior Disorder

A-Synuclein, Gut Dysbiosis, iRBD /

Sialic acid–protein interactions are involved in regulating central nervous systemimmunity; therefore, derangements in sialylation could beinvolved in neurodegeneration. Decreased serum CDTadj is associatedwith substantia nigra degeneration in synucleinopathies.iRBD patients with low CDTadj are more likely tophenoconvert to manifest disease. CLICK TO REVIEW

Increased Transferrin Sialylation Predicts Phenoconversion in
Isolated REM Sleep Behavior Disorder Read More »

Parkinson’s disease: Are gut microbes involved?

Biomarkers, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

Parkinson’s disease (PD) isa common neurodegenerative disorder characterized by motor and gastrointestinal(GI) deficits. Despite its prevalence, the pathophysiology of PD is not wellunderstood. Recent studies highlight the role of gut microbiota in neurologicaldisorders. In this review, we summarize the potential role of gut microbiota inthe pathophysiology of PD. We first describe how gut microbiota can

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Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson’s disease

Gut Dysbiosis, Gut Microbiota, Parkinson's Disease /

Parkinson’s disease (PD) is a common neurodegenerative disorder characterized primarily by motor and non-motor gastrointestinal (GI) deficits. GI symptoms’ including compromised intestinal barrier function often accompanies altered gut microbiota composition and motor deficits in PD. Therefore, in this study, we set to investigate the role of gut microbiota and epithelial barrier dysfunction on motor symptom

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Effects of Endurance Training on Motor Signs of Parkinson’s Disease: A Systematic Review and Meta-Analysis

Parkinson's Disease /

Evidence has demonstrated that endurance training (ET) reduces the motor signs of Parkinson’s disease (PD). However, there has not been a comprehensive meta-analysis of studies to date. ET is effective in decreasing UPDRS-III scores. Questions remain about the dose–response relationship between ET and reduction in motor signs. CLICK TO REVIEW

Effects of Endurance Training on Motor Signs of Parkinson’s Disease: A Systematic Review and Meta-Analysis Read More »

Neuroinflammation as a Common Mechanism Associated with the Modifiable Risk Factors for Alzheimer’s and Parkinson’s Diseases

Parkinson's Disease /

Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) are among the most common causes of dementia, which increasingly contribute to morbidity and mortality worldwide. A common hallmark in the pathogenesis of these two diseases is neuroinflammation, which is initially triggered by the presence of pathological structures associated with these disorders. Chronic neuroinflammation is sustained by persistent

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Periapical Disease and the Prefrontal Cortex. Is there a Relationship between Calcium-Binding Protein and Neurodegenerative Diseases?

endondonics, Endotoxin, Periodontitis /

Apical periodontitis (AP) or periapical lesion (PL) is an inflammatory disease that causes pain, loss of bone and destruction of other tissues of teeth support. This condition could be caused by caries, dental trauma and/or periapical microleakage wich is regulated by the immune system or inflammatory response. Several analyses have shown that endodontic infection can

Periapical Disease and the Prefrontal Cortex. Is there a Relationship between Calcium-Binding Protein and Neurodegenerative Diseases? Read More »