Library

Impact of Contaminants on Microbiota: Linking the Gut–Brain
Axis with Neurotoxicity

Autonmic nervous system, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

: Over the last years, research has focused on microbiota to establish a missing link betweenneuronal health and intestine imbalance. Many studies have considered microbiota as criticalregulators of the gut–brain axis. The crosstalk between microbiota and the central nervous system ismainly explained through three different pathways: the neural, endocrine, and immune pathways,intricately interconnected with each […]

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Axis with Neurotoxicity Read More »

Gut–Brain Axis: Role of Gut Microbiota in Neurodegenerative Disease

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

The role of gut bacteria in neurodegenerative disease has long been speculated; however, the extent of influence and the exact composition of microflora that mechanistically alter outcomes are less understood. While aging was thought to be a major contributor to neurodegenerative disease, the role of the immune system started to become more appreciated bringing the

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Impaired Ocular Tracking and Cortical Atrophy in Idiopathic Rapid Eye Movement Sleep Behavior Disorder

iRBD, Optial, Pre-PD /

We found ocular-tracking abnormalities in patients with iRBD even early in their disease progression that have not been reported before. These abnormalities are coupled with atrophy of brain areas involved in the perception of object motion and might indicate phenoconversion to synucleinopathies in iRBD. © 2022 International Parkinson and Movement Disorder Society. CLICK TO REVIEW

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The Mediterranean Diet as a Source of Bioactive Molecules with
Cannabinomimetic Activity in Prevention and Therapy Strategy

Herbs & Spices, Vitamins / Supplements / Nutraceuticals /

The endocannabinoid system is a complex lipid signaling network that has evolved tobe a key regulator of pro-homeostatic pathways for the organism. Its involvement in numerousprocesses has rendered it a very suitable target for pharmacological studies regarding metabolicsyndrome, obesity and other lifestyle-related diseases. Cannabinomimetic molecules have beenfound in a large variety of foods, most of

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Cannabinomimetic Activity in Prevention and Therapy Strategy Read More »

Chinese herbal medicine treatment based on subgroup differentiation as adjunct therapy for Parkinson’s disease: study protocol of a pilot add-on, randomised, controlled, pragmatic clinical trial

Diet and Exercise, Herbs & Spices, Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

Background Parkinson’s disease (PD) is a prevalent and debilitating condition. Conventional medications cannot control all symptoms and may inflict adverse effects. A survey reported that Chinese herbal medicine (CHM) is frequently sought. Existing CHM trials were contradictory and often of poor quality due to lack of methodological rigor. A national clinical guideline was drafted in

Chinese herbal medicine treatment based on subgroup differentiation as adjunct therapy for Parkinson’s disease: study protocol of a pilot add-on, randomised, controlled, pragmatic clinical trial Read More »

Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease

Anti-oxidants, Autophagy, Diet and Exercise, Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

first_pagesettingsOpen AccessArticle Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease by Hitesh Singh Chaouhan 1,†,Xin Li 1,†,Kuo-Ting Sun 2,3,†,I-Kuan Wang 4,5,Tung-Min Yu 6,7,Shao-Hua Yu 8,Kuen-Bao Chen 9,*,Wei-Yong Lin 10,11,12,* andChi-Yuan Li 1,9,*1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan2Department of Pediatric Dentistry, China Medical University Hospital, Taichung 40402, Taiwan3School of Dentistry, China Medical University, Taichung

Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease Read More »

Gastrointestinal Dysfunction in Parkinson’s Disease

Gut Dysbiosis, Vagal Nerve /

There has been exponential growth in the awareness and understanding of gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) over the past 3 decades. The clinical features of GI dysfunction in PD have been clearly identified and innovative research has demonstrated the presence of pathology within the enteric nervous system (ENS) in individuals with PD, leading

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Evolution of Prodromal Multiple System Atrophy from REM Sleep Behavior Disorder: A Descriptive Study

iRBD, Pre-PD /

Background:Prodromal multiple system atrophy (MSA) has been characterized mainly by retrospective chart reviews. Direct observation and tracking of prodromal markers in MSA have been very limited Objective:To report the baseline characteristics and evolution of prodromal markers of MSA as they were prospectively measured in patients with idiopathic/isolated REM sleep behavior disorder (iRBD) Methods:Patients with iRBD were

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Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in MPTP-Induced Parkinson’s Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder

A-Synuclein, Probiotics, Prebiotics and Symbiotics /

This study aimed to evaluate the attenuating effect of Lactobacillus plantarum DP189 on α-synuclein (α-SYN) aggregates in the substantia nigra (SN) of Parkinson’s disease (PD) mice via 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced. Our results indicated that L. plantarum DP189 increased the levels of superoxide dismutase (SOD), glutathione peroxide (GSH-Px), and interleukin-10 (IL-10) and decreased the levels of malondialdehyde (MDA), reactive oxygen species

Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in MPTP-Induced Parkinson’s Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder Read More »

Biomarkers for REM sleep behavior disorder in idiopathic
and narcoleptic patients

A-Synuclein, iRBD /

To search for discriminating biomarkers, 30 patients with idiopathic rapid-eyemovements sleep behavior disorder (iRBD) were compared with 17 patientswith RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated a-synuclein depositsand whole-night video-polysomnography. Skin biopsy was positive for phosphorylated a-synuclein deposits in 86.7% of iRBD patients and in none

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and narcoleptic patients Read More »