The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on thelocalized regions, microbiota can be classified into gut, oral, respiratory, and skin microbiota. The microbial communities are insymbiosis with the host, contributing to homeostasis and regulating immune function. However, microbiota dysbiosis can lead todysregulation of bodily […]
Microbiota in health and diseases Read More »
The principal pathogenic event in Parkinson’s disease is characterized by the conformational change of α-synuclein, which form pathological aggregates of misfolded proteins, and then accumulate in intraneuronal inclusions causing dopaminergic neuronal loss in specific brain regions. Over the last few years, a revolutionary theory has correlated Parkinson’s disease and other neurological disorders with a shared
Parkinson’s Disease: A Prionopathy? Read More »
The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut microbes and theirhost. Many environmental and host-related factors affect the gut microbiota. Dysbiosis is defined as compositional andfunctional alterations of the gut microbiota that contribute to the pathogenesis, progression and treatment responses todisease. Dysbiosis occurs when perturbations of microbiota composition and function exceed the ability
Aging Microbiota-Gut-Brain Axis in Stroke Risk
and Outcome Read More »
A multicenter cohort of idiopathic/isolated rapid eye movement sleep behavior disorder (iRBD) was studied to determine any predictive factors for α-synuclein–related neurodegenerative illnesses. At the start of the study, patients with iRBD from 12 different sites were given a complete assessment for potential environmental and lifestyle risk factors using a standardized questionnaire. Patients were then
Phenoconversion Risk Factors in Rapid Eye Movement Sleep Behavior Disorder Read More »
Probiotics affect intestinal metabolism and play a crucial role in gut homeostasis. Studies on probiotic effector molecules—bacteriocins, peptidoglycan, teichoic acid, exopolysaccharides, secretory proteins, and short-chain fatty acids—describe their effect on the gut barrier; immune and nervous system; and gut microbiota. However, the detailed mechanism of how the intestinal microbiota changes after the intervention of effector
Modulation of gut health using probiotics: the role of probiotic effector molecules Read More »
Periodontitis triggers systemic repercussions, such as elevated levels of high-sensitive C-reactive protein (hs-CRP). This has neverbeen studied within Parkinson’s Disease (PD). The aim of this study is to compare hs-CRP levels of self-reported periodontitis casesversus cases without periodontitis in PD patients. Data from the National Health and Nutrition Examination Survey (2015–2016 and2017–2018 waves) were analyzed.
Accumulating evidence to date suggests that brown rice is superior to white rice in regards to its beneficial impact on a number of risk factors of the metabolic syndrome (MetS). However, little is known about the influence of fermented brown rice beverage on the gut microbiota in humans. We therefore hypothesized that its impact would
The gut microbiome is associated with diverse diseases1,2,3, but a universal signature of a healthy or unhealthy microbiome has not been identified, and there is a need to understand how genetics, exposome, lifestyle and diet shape the microbiome in health and disease. Here we profiled bacterial composition, function, antibiotic resistance and virulence factors in the
Environmental factors shaping the gut microbiome in a Dutch population Read More »
Fermented foods have been a part of human diet for almost 10,000 years, and their levelof diversity in the 21st century is substantial. The health benefits of fermented foods have beenintensively investigated; identification of bioactive peptides and microbial metabolites in fermentedfoods that can positively affect human health has consolidated this interest. Each fermented foodtypically hosts
Fermented Foods, Health and the Gut Microbiome Read More »
Emerging multi-drug resistant pathogens are the main driving force behind the efforts to find analternative treatment approach such as probiotics. Probiotics are considered living drugs that can reduce theconsumption of conventional antibiotics and improve human and animal health. Particularly, bacterial originprobiotics became increasingly popular during the last two decades as a result of the continuously