Library

Acupoint Massage Therapy Alters the Composition of Gut Microbiome in Functional Constipation Patients

Biomarkers, Gut Dysbiosis, Gut Microbiota, Symptoms / Diagnosis /

The 16S KEGG function prediction suggested that Parkinson disease, retinol metabolism, and arachidonic acid metabolism could explain the biological function of different gut microbiome. Furthermore, cytokines in the serum showed a correlation with the abundance of Pseudobutyrivibrio in CFC. Conclusion. AMT could change the composition of gut microbiome which is associated with cytokines in CFC patients. CLICK TO […]

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Evolution of the Human Diet and Its Impact on Gut Microbiota, Immune Responses, and Brain Health

Butyrate, Diet and Exercise, Gut Microbiota /

Given the tremendous amount of evidence linking neuroinflammation with neural dysfunction, it is no surprise that the Western diet has been implicated in the development of many diseases and disorders of the brain, including memory impairments, neurodegenerative disorders, and depression. In this review, we discuss each of these concepts to understand how what we eat

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Physical activity as a mediator of anxiety and cognitive functioning in Parkinson’s disease

Diet and Exercise /

Analyses revealed a significant direct effect of anxiety predicting cognitive functioning. Additionally, there was a significant indirect within-person effect; meaning that individuals who became more anxious over time, they also reported becoming less physically active, which was subsequently associated with longitudinal declines in cognitive functioning. CLICK TO REVIEW

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Olfactory impairment as an early marker of Parkinson’s disease in REM sleep behavior disorder: a systematic review and meta-analysis

Biomarkers, iRBD, Olfactory /

We identified similar olfactory impairments in patients with RBD and patients with PD (either with or without underlying RBD). These findings suggest that olfactory impairment may be a sensitive and stable diagnostic biomarker of RBD and appears to be useful for identifying patients with idiopathic RBD at high risk for early conversion to PD. CLICK

Olfactory impairment as an early marker of Parkinson’s disease in REM sleep behavior disorder: a systematic review and meta-analysis Read More »

Probiotics : A Dietary Factor to Modulate the Gut Microbiome, Host Immune System, and Gut–Brain Interaction

Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

Abstract: Various benefits of probiotics to the host have been shown in numerous human clinical trials. These organisms have been proposed to act by improving the balance of the gut microbiota and enhancing the production of short-chain fatty acids, as well as by interacting with host cells in the gastrointestinal tract, including immune cells, nerve

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The potential of human milk oligosaccharides to impact the microbiota-gutbrain axis through modulation of the gut microbiota

Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

ABSTRACT: Human milk oligosaccharides (HMOs) are the first prebiotics humans meet in life. HMOs provide many benefits to infants including impact on gut bacteria, promotion of postnatal brain development, and modulation of the immune system. A complex bidirectional communication pathway called the microbiota-gut-brain axis links gut homeostasis and microbial composition with the central nervous system

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Probiotic Bacillus subtilis Protects against a-Synuclein Aggregation in C. elegans

A-Synuclein, Probiotics, Prebiotics and Symbiotics /

Recent discoveries have implicated the gut microbiome in the progression and severity of Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits a synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans model of synucleinopathy. CLICK TO REVIEW

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Pathophysiology of Parkinson’s disease:
Mitochondria, alpha-synuclein and much more. . .

A-Synuclein, Gut-Brain axis, Mitochondria /

ABSTRACT: Here, we give an overview of the progress that has been made over the past four decades in our understanding of this disorder. We review the role of mitochondria, environmental toxicants, alpha-synuclein and neuroinflammation in the development of PD. We also discuss more recent data from genetics, which strongly support the endosomal-lysosomal pathways and

Pathophysiology of Parkinson’s disease:
Mitochondria, alpha-synuclein and much more. . . Read More »

A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice

iRBD /

During rapid eye movement (REM) sleep, anti-gravity muscle tone and bodily movements are mostly absent, because somatic motoneurons are inhibited by descending inhibitory pathways. Recent studies showed that glycine/GABA neurons in the ventromedial medulla (VMM) (GlyVMM neurons) play an important role in generating muscle atonia during REM sleep (REM-atonia). CLICK TO REVIEW

A discrete glycinergic neuronal population in the ventromedial medulla that induces muscle atonia during REM sleep and cataplexy in mice Read More »