Library

Gut microbiota: a potential therapeutic target for Parkinson’s disease

Gut Dysbiosis, Gut Microbiota /

If therapeutic manipulation of gut microbiota proves effective to treat some pathogenic aspects of PD, an important inquiry would be at which point of the disease evolution these therapies should be implemented. It is accepted that microbiota conformation is shaped early in life with relative minor changes later on. However, patients with rapid eye movement-sleep […]

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Increasing Comparability and Utility of Gut Microbiome Studies in Parkinson’s Disease: A Systemic Review

Gut Microbiota /

To move from the current heterogeneous dataset towards clinically relevant biomarkers and the identification of putative therapeutic targets, recommendations are derived from the limitations of the available studies to increase the future comparability of microbiome studies in PD. In addition, integration of currently available data on the gut microbiome in PD is proposed to identify

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Effects of dietary restriction on neuroinflammation in neurodegenerative diseases

Diet and Exercise, Gut Microbiota /

Chronic or intermittent food restriction has profound effects in shaping brain and peripheral metabolism, immunity, and gut microbiome biology. Interactions among calorie intake, meal frequency, diet quality, and the gut microbiome modulate specific metabolic and molecular pathways that regulate cellular, tissue, and organ homeostasis as well as inflammation during normal brain aging and CNS neurodegenerative

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Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics and Synbiotics

Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

Pre-clinical and human clinical trial data reveal exciting potential for novel treatment targets and therapeutic modulation with prebiotics, medicinal herbs, probiotics, and synbiotics in health, aging, and neurodegeneration and are reviewed here. While greater insights and characterization of the microbiota-gut-brain axis have been revealed over the past decade, salient questions related to the pathology, pathogenesis

Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics and Synbiotics Read More »

Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases

Diet and Exercise, Library, Mitochondria /

We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases. CLICK TO REVIEW

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High intensity aerobic exercise improves information processing and motor performance in individuals with Parkinson’s disease

Diet and Exercise /

The improvement in information processing following aerobic exercise, but not levodopa administration, suggests high intensity exercise may be enhancing neural processing and non-motor pathways outside those impacted by medication. The persistence of symptom improvement despite exercise intervention cessation indicates exercise is a candidate for disease modification.  CLICK TO REVIEW

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Astaxanthin Alleviates Ochratoxin A-Induced Cecum Injury and Inflammation in Mice by Regulating the Diversity of Cecal Microbiota and TLR4/MyD88/NF-κB Signaling Pathway

Anti-oxidants, Butyrate, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

Ochratoxin A (OTA) is a common environmental pollutant found in a variety of foods and grains, and excessive OTA consumptioncauses serious global health effects on animals and humans. Astaxanthin (AST) is a natural carotenoid that has anti-inflammatory,antiapoptotic, immunomodulatory, antitumor, antidiabetes, and other biological activities. The present study is aimed atinvestigating the effects of AST on

Astaxanthin Alleviates Ochratoxin A-Induced Cecum Injury and Inflammation in Mice by Regulating the Diversity of Cecal Microbiota and TLR4/MyD88/NF-κB Signaling Pathway Read More »

Novel perspectives for neurodegeneration prevention: effects of bioactive polyphenols

Diet and Exercise, Polyphenols, Vitamins / Supplements / Nutraceuticals /

Neurodegenerative diseases are becoming a big challenge for modern society. Neurodegenerative disorders strongly impact on patient and their caregivers. Moreover, since the population is becoming older, these pathologies will deeply influence medical and socio-economic conditions in the next years. CLICK TO REVIEW

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Unmet needs in Parkinson disease: Motor and non-motor

Pre-PD, Symptoms / Diagnosis /

Characterizing the clinical phenotype of the entire non-motor profile of PD is challenging. Further research and understanding are needed for discovering biomarkers of certain NMS, such as dementia, fatigue, pain, sleep, and apathy. More work is needed to gather a robust evidence base for guiding treatment of troubling NMS, which exert a major impact on

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