Library

The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson’s disease?

Probiotics, Prebiotics and Symbiotics /

This review will discuss the potential use of probiotics for Parkinson’s disease prevention or treatment or as adjuvant therapy, confirming that gut microbiota modulation influences different pro-survival pathways. Future investigations in Parkinson’s disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary. CLICK TO REVIEW

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Oxidative Stress in Parkinson’s Disease: Potential Benefits of Antioxidant Supplementation

Anti-oxidants, Vitamins / Supplements / Nutraceuticals /

Oxidative stress is highlighted as an important factor in the genesis of PD, involving several enzymes and signaling molecules in the underlying mechanisms of the disease. This review presents updated data on the involvement of oxidative stress in the disease, as well as the use of antioxidant supplements in its therapy CLICK TO REVIEW

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Faecal Transplantation, Pro- and Prebiotics in Parkinson’s Disease; Hope or Hype?

A-Synuclein, Fecal Transplants (FMT), Probiotics, Prebiotics and Symbiotics /

. Faecal microbiome transplantation (FMT) is an attractive technique, because the administration is relatively simpleand in general has a mild adverse effect pattern. Moreover, FMT consists of a broad mixture, which could be beneficial,because at this moment it is not known what type of changes in the microbiome are needed. However, except from a fewcases

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Bacterial Metabolites Mirror Altered Gut Microbiota Composition in Patients with Parkinson’s Disease

Gut Microbiota, Short Chain Fatty Acids /

Increasing evidence is supporting the hypothesis of -synuclein pathology spreading from the gut to the brainalthough the exact etiology of Parkinson’s disease (PD) is unknown. Furthermore, it has been proposed that inflammation,via the gastrointestinal tract, potentially through infections, may contribute to -synuclein pathogenesis, and thus to the riskof developing PD. CLICK TO REVIEW

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Fecal transplants as a microbiome-based therapeutic

Fecal Transplants (FMT), Therapies /

Impaired microbiome diversity and composition can develop into a potent etiological agent of disease and increase susceptibility to infection. Given this, interventions targeting the microbiome have developed rapidly, with healthy donor feces being a de facto source of beneficial communities employed to rebalance patients’ microbiomes. Recent evidence has demonstrated that bacterial and viral richness, short

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COVID-19 mortality increases with northerly latitude after adjustment for age suggesting a link with ultraviolet and vitamin D

Virus /

We previously reported a north–south gradient in global COVID-19 mortality but were conscious that lack of ultraviolet exposure and consequent vitamin D insufficiency was not the only possible explanation. We have now investigated the relationships between latitude, age of population, population density and pollution with COVID-19 mortality   CLICK TO REVIEW

COVID-19 mortality increases with northerly latitude after adjustment for age suggesting a link with ultraviolet and vitamin D Read More »

SARS-CoV-2 positivity rates associated with
circulating 25-hydroxyvitamin D levels

Virus /

Until treatment and vaccine for coronavirus disease-2019 (COVID-19) becomes widely available, other methods of reducing infection rates should be explored. This study used a retrospective, observational analysis of deidentified tests performed at a national clinical laboratory to determine if circulating 25-hydroxyvitamin D (25(OH)D) levels are associated with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) positivity

SARS-CoV-2 positivity rates associated with
circulating 25-hydroxyvitamin D levels Read More »