Assays that specifically measure a-synuclein seeding activity inbiological fluids could revolutionize the diagnosis of Parkinson’s disease. Recentimprovements in a-synuclein real-time quaking-induced conversion assays ofcerebrospinal fluid have dramatically reduced reaction times from 5-13 daysdown to 1-2 days. Click here for report
Our improved α-synuclein seed amplification assay dramatically reduces the time needed to diagnose Parkinson’s disease while maintaining the high-performance standards associated with previous α-synuclein seed assays, supporting the clinical utility of this assay for Parkinson’s disease diagnosis. https://doi.org/10.1002/acn3.51280
More attention than ever is being put on your gut health, and understandably so, considering a significant proportion of your immune system resides in your gastrointestinal tract.1 As such, optimizing your gut microbiome is a worthwhile pursuit that will have far-reaching effects on your physical health and emotional well-being. Mounting scientific evidence also continues to suggest
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The microbiome lies at the forefront of scientific research, as researchers work to uncover its mysterious influence on human development and disease. Though the clinical applications of microbiome manipulation are currentlylimited, the significance of dysbiosis in the etiology of a wide array of diseases indicates the significance of this research and highlights the need for
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In response to behaviorally salient stimuli, dopamine (DA) neuronsfire in bursts. These data show that the LDTg is critical to normal DA function,and thus, pathology within this region may lead to aberrant DAsignaling. http://www.pnas.orgcgidoi10.1073pnas.0510715103
Neurodegenerative diseases, Parkinson disease among them, set challenges to modern societies both in terms of premature deaths and resources spent on treatment of the diseases. At that, preventive care and early diagnostics in particular are potential directions towards higher economic efficiency of healthcare interventions in this area. https://doi.org/10.3897/popecon.4.e59949
A large and convincing body of evidence demonstrated that aging is characterized by a progressive decline in the efficiency of physiological functions due to the consequence of free radical-induced damage to cellular macromolecules. https://doi.org/10.1155/2018/3416028
The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson’s disease (PD) progression. These are the first data to provide evidence that targeted nutrition is associated with the rate of PD progression. https://doi.org/10.1155/2017/6405278
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Sleep Disorders (SDs) precede motor symptoms of Parkinson’s disease (PD), suggesting an early effect of disease processes on sleep control neurons. These nucleus-specific differential effects suggest previously unappreciated, mechanistic underpinnings of SDs’ prodromal PD appearance in PD, and wehypothesize that in the prodromal phase of PD, the early form of α-synuclein compromises sleep-control neurons. https://doi.org/10.21203/rs.3.rs-134060/v1
Neuronal lesions in Parkinson’s disease (PD) are commonly associated with α-synuclein (α-Syn)-induced cell damage that are present both in the central and peripheral nervous systems of patients, with the enteric nervous system also being especially vulnerable. Here, we bring together evidence that the development and presence of PD depends on specific sets of interlinking factors