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Fermented foods: an update on evidence-based health benefits and future perspectives

Probiotics, Prebiotics and Symbiotics /

In recent years, an unstoppable trend toward minimally processed foods has increased the popularity of fermented foods as a beneficial nutritional and functional strategy. Within food fermentations, complex microbial communities trigger different biochemical reactions that result in the release of multiple bioactive compounds with beneficial effect on human health. In the present review the latest […]

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Short-Chain Fatty Acids Modulate Healthy Gut Microbiota Composition and Functional Potential

Biomarkers, Butyrate, Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids /

Many studies have focused on the metabolic capacity of human gut microbiota to produce short-chain fatty acids and subsequent effects on host physiology. Given scarce data on how SCFAs produced by gut bacteria participate in cross-feeding to influence community structure and function, we evaluated the potential of SCFAs to modulate human gut microbiota in vitro.

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Relationships of Nutritional Factors and Agrochemical Exposure with Parkinson’s Disease in the Province of Brescia, Italy

A-Synuclein, Diet and Exercise, Gut Dysbiosis, Parkinson's Disease /

Environmental exposures to agrochemicals and nutritional factors may be associated with Parkinson’s Disease (PD). None of the studies to date has examined the combined effects of diet and agricultural chemical exposure together. To address these research gaps, we aimed to assess the association of nutritional factors and agrochemical exposure with the risk of PD. A

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Brain-Gut-Microbiota Axis in Schizophrenia and Parkinson’s
Disease

Gut Dysbiosis, Gut-Brain axis, Parkinson's Disease, Pre-PD, Vagal Nerve /

Dopaminergic cells, which use dopamine as a neurotransmitter, arenot as numerous as other brain nerve cells such as serotonergic andGABAergic neurons. However, dopamine neurons project to a varietyof important brain regions to control movement, emotion, the rewardsystem, and the secretion of prolactin. Both schizophrenia andParkinson’s disease are disorders of the dopaminergic neurotransmissions, but schizophrenia has

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Disease Read More »

Review on Dietary Factors in Fermented Foods and their Efficacy in Disease Management

Diet and Exercise, Probiotics, Prebiotics and Symbiotics /

The process of preservation of various food sources, over time, gave rise to fermented foods. Traditionally, each ethnic group has its distinct fermented food(s) incorporated into their diet, both as culinary enjoyment and nutrition. Fermentation increases nutrient availability and enhances the texture and flavor of the original food. The benefits of fermented food consumption and

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Mycotherapy: Potential of Fungal Bioactives for the Treatment
of Mental Health Disorders and Morbidities of Chronic Pain

Diet and Exercise /

Mushrooms have been used as traditional medicine for millennia, fungi are the main natural source of psychedelic compounds. There is now increasing interest in using fungal active compounds such as psychedelics for alleviating symptoms of mental health disorders including majordepressive disorder, anxiety, and addiction. The anxiolytic, antidepressant and anti-addictive effectof these compounds has raised awareness

Mycotherapy: Potential of Fungal Bioactives for the Treatment
of Mental Health Disorders and Morbidities of Chronic Pain Read More »

The role of the probiotic Akkermansia muciniphila in brain functions: insights underpinning therapeutic potential

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

The role of Akkermansia muciniphila, one of the most abundant microorganisms of the intestinalmicrobiota, has been studied extensively in metabolic diseases, such as obesity and diabetes. Itis considered a next-generation probiotic microorganism. Although its mechanism of action hasnot been fully elucidated, accumulating evidence indicates the important role of A. muciniphilain brain functions via the gut-brain

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Association of Fecal and Plasma Levels of Short-Chain Fatty Acids With Gut Microbiota and Clinical Severity in Parkinson Disease Patients

A-Synuclein, Butyrate, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

We are grateful for the comment on our study.1 We are pleased to know that short chain fatty acids (SCFA), especially butyrate, in the intestine could stimulate the colonization of curli-producing Escherichia coli (E. coli). Curli are functional amyloids produced by gut microbes and act as cross-beta-sheet amyloid polymers to assist bacterial cells in binding to

Association of Fecal and Plasma Levels of Short-Chain Fatty Acids With Gut Microbiota and Clinical Severity in Parkinson Disease Patients Read More »

Sleep Disorders and Autonomic Nervous System Dysfunction

iRBD, Pre-PD /

Parasympathetic nervous system activity dominates during non-rapid eye movement (REM) sleep, whereas the sympathetic nervous system is dominant during REM sleep. The balance between the sympathetic and parasympathetic nervous systems reduces the heart rate and blood pressure during non-REM sleep and increases these parameters during REM sleep and wakefulness. Heart rate variability analysis, a non-invasive

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Exploiting Caenorhabditis elegans to discover human gut microbiota-mediated intervention strategies in protein conformational diseases

A-Synuclein, Biomarkers, Butyrate, Gut Dysbiosis, Probiotics, Prebiotics and Symbiotics /

Age-dependent protein-conformational diseases (PCDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), or amyotrophic lateral sclerosis (ALS), are characterized by misfolding and aggregation of metastable proteins present within the proteome of the affected individual. Recent evidence supports the notion that bacteria and bacterial products may be affecting the stability of these culprit host proteins and

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