Parkinson’s Disease

Western and ketogenic diets in neurological disorders: can you tell the difference?

Diet and Exercise, Metabolites, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

The prevalence of obesity tripled worldwide between 1975 and 2016, and it is projected that half of the US population will be overweight by 2030. The obesity pandemic is attributed, in part, to the increasing consumption of the high-fat, high-carbohydrate Western diet, which predisposes to the development of the metabolic syndrome and correlates with decreased […]

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Relationship between risk and protective factors and clinical features of Parkinson’s disease

Biomarkers, Parkinson's Disease, Pre-PD /

Risk and protective factors of PD development may influence PD clinical features. This finding may represent the first step in the development of new preventive approaches able to delay disease onset and mitigate the extent of clinical manifestations. CLICK TO REVIEW

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Hyperbaric Oxygen Therapy Improves Parkinson’s Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway

Biomarkers, Mitochondria, Parkinson's Disease, Pre-PD /

Hyperbaric oxygen therapy (HBOT) has been suggested as a potential adjunctive therapy for Parkinson’s disease (PD). PD is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The aim of this study was to investigate the protective mechanisms of HBOT on neurons and motor function in

Hyperbaric Oxygen Therapy Improves Parkinson’s Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway Read More »

Proof of Concept Study of Prebiotics to Modulate Gut Microbiome in Parkinson’s Disease

Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Consumption of a novel prebiotic mixture rapidly impacted the intestinal microbiota (10 days), reduced the abundance of pro-inflammatory bacteria and promoted the growth of beneficial SCFA-producing bacteria. In addition, prebiotic consumption increased plasma SCFA levels, and improved markers of intestinal barrier integrity and brain health. This proof-of-concept study provides evidence for the importance of intestinal

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Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson’s disease

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD /

Growing evidences show that gut microbiota is associated with the pathogenesis of Parkinson’s disease (PD) and the gut-brain axis can be promising target for the development of the therapeutic strategies for PD. Acupuncture has been used to improve brain functions and inflammation in neurological disorders such as PD, and to recover the gastrointestinal dysfunctions in

Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson’s disease Read More »

Research progress on the association of neurological disorders and periodontal diseases

endondonics, Oral Microbiome, Parkinson's Disease, Pre-PD /

Periodontal diseases are inflammatory diseases caused by oral pathogens around the periodontal supporting tissues, leading to systemic and chronic inflammatory conditions. The continuous chronic systemic inflammation may be a trigger of neuroinflammation, which is the prominent feature of a variety of neurological disorders. It implies that there may be a causal link between periodontal diseases

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New research reveals sleep disorder may be linked to Parkinson’s

iRBD, Parkinson's Disease, Pre-PD /

New research on the connection between sleep and Parkinson’s disease is being hailed as a “first step” toward curing and preventing the condition, a brain disorder that causes uncontrollable movements. The research, led by the Parkinson’s Progression Markers Initiative, funded by The Michael J. Fox Foundation, is working to make a concrete connection between Parkinson’s and REM sleep

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Mucin modifies microbial composition and improves metabolic
functional potential of a synthetic gut microbial ecosystem

Gut Dysbiosis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Microbial dysbiosis in the gut is associated withhuman diseases, and variations in mucus alter gut microbiota.Therefore, we explored the effects of mucin on the gut microbiotausing a community of 19 synthetic gut microbial species. Cultivationof these species in modified Gifu anaerobic medium (GAM)supplemented with mucin before synthetic community assemblyfacilitated substantial growth of the Bacteroides, Akkermansia,and

Mucin modifies microbial composition and improves metabolic
functional potential of a synthetic gut microbial ecosystem Read More »

The Future of Parkinson’s Disease Research: A New Paradigm of Human-Specific
Investigation Is Necessary… and Possible

Parkinson's Disease /

Parkinson’s disease (PD) is a complex neurodegenerative condition with a multifactorial origin. To date, approaches todrug discovery for PD have resulted in symptomatic therapies for the motor manifestations and signs associated withneurodegeneration but have failed to identify preventive or curative therapies. This failure mainly originates from thepersistence of major gaps in our understanding of the

The Future of Parkinson’s Disease Research: A New Paradigm of Human-Specific
Investigation Is Necessary… and Possible Read More »

Phenoconversion Risk Factors in Rapid Eye Movement Sleep Behavior Disorder

Biomarkers, Enviromental, iRBD, Parkinson's Disease, Pesticides, Pre-PD /

A multicenter cohort of idiopathic/isolated rapid eye movement sleep behavior disorder (iRBD) was studied to determine any predictive factors for α-synuclein–related neurodegenerative illnesses. At the start of the study, patients with iRBD from 12 different sites were given a complete assessment for potential environmental and lifestyle risk factors using a standardized questionnaire. Patients were then

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