Parkinson’s Disease

Overview on Parkinson’s disease: pathophysiology, and experimental models

Parkinson's Disease /

Parkinson’s disease, a neurodegenerative disease, is caused by dopaminergic neurons death and accompanied byrigidity, and postural instability, as well as bradykinesia. The cause of these neurons’ death is still unclear. Since thedopaminergic neurons couldn’t regenerate, therefore Parkinson’s disease couldn’t be cured. Thus, over the pastdecades, significant effort has been made to explore the etiology of […]

Overview on Parkinson’s disease: pathophysiology, and experimental models Read More »

Physical Activity vs. Redox Balance in the Brain: Brain Health, Aging and Diseases

Diet and Exercise, Parkinson's Disease /

It has been proven that physical exercise improves cognitive function and memory, hasan analgesic and antidepressant effect, and delays the aging of the brain and the development ofdiseases, including neurodegenerative disorders. There are even attempts to use physical activity inthe treatment of mental diseases. The course of most diseases is strictly associated with oxidativestress, which

Physical Activity vs. Redox Balance in the Brain: Brain Health, Aging and Diseases Read More »

Parkinson’s Disease and the Metal–Microbiome–Gut–Brain Axis: A Systems Toxicology Approach

Detox, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Parkinson’s Disease (PD) is a neurodegenerative disease, leading to motor and nonmotor complications. Autonomic alterations, including gastrointestinal symptoms, precede motordefects and act as early warning signs. Chronic exposure to dietary, environmental heavy metalsimpacts the gastrointestinal system and host-associated microbiome, eventually affecting the centralnervous system. The correlation between dysbiosis and PD suggests a functional and bidirectionalcommunication

Parkinson’s Disease and the Metal–Microbiome–Gut–Brain Axis: A Systems Toxicology Approach Read More »

Homeostatic regulation of neuronal excitability by probiotics in male germ-free mice

Gut-Brain axis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Emerging evidence indicates that probiotics can influence the gut–brain axis to ameliorate somatic and behavioral symptoms associated with brain disorders. However, whether probiotics have effects on the electrophysiological activities of individual neurons in the brain has not been evaluated at a single-neuron resolution, and whether the neuronal effects of probiotics depend on the gut microbiome

Homeostatic regulation of neuronal excitability by probiotics in male germ-free mice Read More »

Molecular Docking Studies of Secondary Metabolites against Sequestosome-1 to Treat Parkinson Disease

Metabolites, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is one of the major progressive neurological disorders. It occurs due to a low level of achemical substance in the brain known as Dopamine, which controls the muscle movements of the body. In many cases, PDoccurs due to a low level of dopamine. PD generally appears in persons between the ages of

Molecular Docking Studies of Secondary Metabolites against Sequestosome-1 to Treat Parkinson Disease Read More »

Trajectory Analysis of Orthostatic Hypotension in Parkinson’s Disease: Results From Parkinson’s Progression Markers Initiative Cohort

Biomarkers, Orthostatic Hypotension, Parkinson's Disease, Pre-PD /

This study provides new information on the longitudinal development of ΔSBP in patients with PD with distinct trajectories of rapidly increasing, low-stable, and high-stable class. Male sex, lower supine DBP, and lower total proteins helped to identify the class with increasing risk for OH. Further research is needed to discover the biological mechanisms that explain

Trajectory Analysis of Orthostatic Hypotension in Parkinson’s Disease: Results From Parkinson’s Progression Markers Initiative Cohort Read More »

Environmental triggers of Parkinson’s disease – Implications of the Braak and dual-hit hypotheses

A-Synuclein, Biomarkers, Gut Dysbiosis, Gut Permeability / Leaky Gut, Gut-Brain axis, Olfactory, Parkinson's Disease, Pre-PD /

Idiopathic Parkinson’s disease (PD) may take decades to develop, during which many risk or protective factors may come into play to initiate the pathogenesis or modify its progression to clinical PD. The lack of understanding of this prodromal phase of PD and the factors involved has been a major hurdle in the study of PD

Environmental triggers of Parkinson’s disease – Implications of the Braak and dual-hit hypotheses Read More »

Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration

A-Synuclein, Gut Dysbiosis, Gut Microbiota, Lipopolysaccharides (LPS), Oral Microbiome, Parkinson's Disease, Pre-PD /

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Creutzfeldt–Jakob disease (CJD) are brain conditions affecting millions of people worldwide. These diseases are associated with the presence of amyloid-β (Aβ), alpha synuclein (α-Syn) and prion protein (PrP) depositions in the brain, respectively, which lead to synaptic disconnection and subsequent progressive neuronal death. Although

Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration Read More »

Gut Health Guide; Essential Oils Protocol

Gut Dysbiosis, Gut Permeability / Leaky Gut, Herbs & Spices, Parkinson's Disease /

IntroductionThere’s a reason we shorten the Standard American Diet to S-A-D. Never has amore fitting abbreviation been seen in the health industry. Our food, and theway our body processes that food, impacts our health in profound ways.And, it all starts in the gut.Put simply, when our gut isn’t healthy and happy, nothing about our bodies

Gut Health Guide; Essential Oils Protocol Read More »

Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson’s diseas

A-Synuclein, Biomarkers, Parkinson's Disease, Pre-PD /

The proximity ligation assay (PLA) is a specific and sensitive technique for the detection of αSyn oligomers (αSyn-PLA), early and toxic species implicated in the pathogenesis of PD. We aimed to evaluate by skin biopsy the diagnostic and prognostic capacity of αSyn-PLA and small nerve fiber reduction in PD in a longitudinal study. αSyn-PLA was

Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson’s diseas Read More »