Parkinson’s Disease

Composition of intestinal flora affects the risk relationship between Alzheimer’s disease/Parkinson’s disease and cancer

Gut Microbiota, Gut Permeability / Leaky Gut, Hydrogen, Parkinson's Disease, Pre-PD /

An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer’s disease/Parkinson’s disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, […]

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Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models

Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

Parkinson’s disease (PD) is a neurodegenerative disordercharacterized by a progressive loss of dopaminergic neu-rons in the substantia nigra (SN). The present study wasdesigned to examine the therapeutic effect of hydrogensulfide (H2S, a novel biological gas) on PD. The endoge-nous H2S level was markedly reduced in the SN in a6-hydroxydopamine (6-OHDA)-induced PD rat model. Sys-temic administration

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Plant derived bioactive compounds and their potential to enhance adult neurogenesis

Anti-oxidants, Herbs & Spices, Parkinson's Disease, Pre-PD /

Self-renewal and proliferation of neural progenitor cells occur throughout humans’ lives. However, aging, stress, and degenerative diseases can hinder or stop the process. If you can accelerate neurogenesis in adults, this is a promising way to recover from neurodegeneration and cognitive impairments. As the demand for a safer and natural therapeutic product has increased over

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Dual role of microbiota-derived short-chain fatty acids on host and pathogen

Butyrate, Gut Microbiota, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

A growing body of documents shows microbiota produce metabolites such as short-chain fatty acids (SCFAs) as crucial executors of diet-based microbial influence the host and bacterial pathogens. The production of SCFAs depends on the metabolic activity of intestinal microflora and is also affected by dietary changes. SCFAs play important roles in maintaining colonic health as

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Review of Metabolomics-Based Biomarker Research for Parkinson’s Disease

Biomarkers, Metabolites, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD), as the second most common neurodegenerative disease, is seriously affecting the life quality of the elderly. However, there is still a lack of efficient medical methods to diagnosis PD before apparent symptoms occur. In recent years, clinical biomarkers including genetic, imaging, and tissue markers have exhibited remarkable benefits in assisting PD diagnoses.

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To search for targets of therapy that changes the course of Parkinson’s disease

A-Synuclein, Parkinson's Disease, Pre-PD /

Abstract .Background. Parkinson’s disease (PD) is a multisystem disease that requires a more comprehensive approach to its study and treatment. The purpose was to give clinical and laboratory characteristics of PD patients, in whom the onset of motor symptoms of the disease is associated with the action of precipitating factors and provide a theoretical justification

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Orthostatic Hypotension: JACC State-of-the-Art Review

Autonmic nervous system, Non-Motor Symptoms, Orthostatic Hypotension, Parkinson's Disease, Pre-PD /

Neurogenic orthostatic hypotension is a highly prevalent and disabling feature of autonomic failure due to both peripheral and central neurodegenerative diseases. Community-based epidemiological studies have demonstrated a high morbidity and mortality associated with neurogenic orthostatic hypotension. It is due to impairment of baroreflex-mediated vasoconstriction of the skeletal muscle and splanchnic circulation and is caused by damage

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Association Between Parkinson’s Disease and Atrial Fibrillation: A Population-Based Study

A-Synuclein, Autonmic nervous system, Parkinson's Disease, Pre-PD /

Autonomic nervous system (ANS) dysfunction contributes to several non-motor symptoms of Parkinson’s disease (PD). In addition, ANS plays a role in the genesis and maintenance of atrial fibrillation (AF). This study investigated the temporal association between PD and AF. This study demonstrated that the premotor and early stages of PD were comorbid with AF, whereas

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Taurine protects dopaminergic neurons in paraquat-induced Parkinson’s disease mouse model through PI3K/Akt signaling pathways

Parkinson's Disease, Pre-PD /

Taurine (Tau) is one of the most abundant amino acids in the brain and regulates physiological functions in the central nervous system, including anti-inflammatory effects. There is growing evidence that microglia-mediated neuro-inflammatory responses are an integral part of Parkinson’s disease (PD) onset and progression. Among the many factors regulating the inflammatory response, phosphatidylinositol-3 kinase (PI3K)

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