Parkinson’s Disease

Gingival Crevicular Fluid as Biomarker’s Source for Alzheimer’s Disease

Oral Microbiome, Parkinson's Disease, Periodontitis, Pre-PD, Root Canal /

Periodontitis is a low-grade inflammatory disease caused by a subgingivaldysbiotic microbiota. Multiple studies have determined the higher prevalence of toothloss and poor oral hygiene in patients with Alzheimer’s disease (AD). However, theperiodontal diagnosis, periodontal bacteria or mediators has not been measuredto date. Aim: To determine the periodontal status, the pro-inflammatory mediators,Porphyromonas gingivalis load, and Apoliporpotein […]

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Psychedelic-Inspired Approaches for Treating Neurodegenerative Disorders

Ayahuasca, Parkinson's Disease, Pre-PD /

Psychedelics are increasingly being recognized for their potential to treat a wide range of braindisorders including depression, post-traumatic stress disorder (PTSD), and substance use disorder.Their broad therapeutic potential might result from an ability to rescue cortical atrophy common tomany neuropsychiatric and neurodegenerative diseases by impacting neurotrophic factor geneexpression, activating neuronal growth and survival mechanisms, and

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Effect of vagotomy on modulation of dopaminergic neurons in Parkinson’s disease

A-Synuclein, Gut-Brain axis, Parkinson's Disease, Vagal Nerve /

Our results suggest that vagotomy has protective effects onnigrostriatal dopaminergic degeneration and disease progression insubsequent Parkinson’s disease, but may be unfavorable for cognitiveperformance. The neuroprotective effect of vagotomy could be largelymediated by blocking the spread of α-synuclein from the gut to the brain,and the modulation of inflammatory response might also contribute tosome extent. CLICK TO

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The Role of Dysbiosis in Neurological Disorders

Biomarkers, Butyrate, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Metabolites, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The gut brain axis is a system of bi-directional communication. When the delicate balance of the microbiome is disrupted, the resulting dysbiosis can be a factor in the development of neurological disorders, including Alzheimer’s Disease (AD), Parkinson’s Disease (PK), and Multiple Sclerosis (MS). One major player in the gut brain axis are short-chain fatty acids

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The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

Anti-oxidants, Constipation, Diet and Exercise, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Metabolites, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The fact that millions of people worldwide suffer from Alzheimer’s disease (AD) orParkinson’s disease (PD), the two most prevalent neurodegenerative diseases (NDs), has beena permanent challenge to science. New tools were developed over the past two decades andwere immediately incorporated into routines in many laboratories, but the most valuable scientificcontribution was the “waking up” of

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Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson’s Disease

Gut-Brain axis, Lectins, Parkinson's Disease, Vagal Nerve /

Lectins from dietary plants have been shown to enhance drug absorption in the gastrointestinal tract of rats, be transported trans-synaptically as shown by tracing of axonal and dendritic paths, and enhance gene delivery. Other carbohydrate-binding protein toxins are known to traverse the gut intact in dogs. Post-feeding rhodamine- or TRITC-tagged dietary lectins, the lectins were

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An Update on the Critical Role of α-Synuclein in Parkinson’s Disease and Other Synucleinopathies: from Tissue to Cellular and Molecular Levels

A-Synuclein, Parkinson's Disease /

The aggregation of alpha-synuclein (α-Syn) plays a critical role in the development of Parkinson’s disease (PD) and other synucleinopathies. α-Syn, which is encoded by the SNCA gene, is a lysine-rich soluble amphipathic protein normally expressed in neurons. Located in the cytosolic domain, this protein has the ability to remodel itself in plasma membranes, where it

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Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut

Biomarkers, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

With the increasing amount of evidence linking certain disorders of the human body to a disturbed gut microbiota, there is a growing interest for compounds that positively influence its composition and activity through diet. Besides the consumption of probiotics to stimulate favorable bacterial communities in the human gastrointestinal tract, prebiotics such as inulin-type fructans (ITF)

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Diet Quality and Risk of Parkinson’s Disease: The Rotterdam Study

Diet and Exercise, Parkinson's Disease, Pre-PD /

The Mediterranean diet has been associated with the risk of Parkinson’s disease (PD),but limited research has been performed on other dietary patterns. We studied the relationshipbetween overall diet quality and PD risk in the general population. We included 9414 participantsfrom the Rotterdam Study, a prospective population-based study in the Netherlands. Diet wasdefined using a Dutch

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