Parkinson’s Disease

Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease

Fecal Transplants (FMT), Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids, Vagal Nerve /

In recent years, human gut microbiota have become one of the most promising areasof microorganism research; meanwhile, the inter-relation between the gut microbiota and varioushuman diseases is a primary focus. As is demonstrated by the accumulating evidence, the gastrointestinal tract and central nervous system interact through the gut–brain axis, which includesneuronal, immune-mediated and metabolite-mediated pathways. […]

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Neuropathological evidence of body-first vs. brain-first Lewy body disease

A-Synuclein, Dementia - Lewy Bodies, Parkinson's Disease /

Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB). In the majority of post mortem cases, the distribution of Lewy pathology seems to follow two overarching patterns: a caudo-rostral pattern with relatively more pathology in the brainstem than in the telencephalon, and an amygdala-centered pattern with the most

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Shining light on the head: Photobiomodulation for brain disorders

Parkinson's Disease, Photobiomodulation (PBM) /

Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. One of the organ systems of the human body that is most necessary to life, and whose optimum functioning is most worried about by

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Is Red Light a Missing Nutrient for Our Health? Podcast with Dr. Michael Hamblin

Mitochondria, Parkinson's Disease /

Light is essential to life as we know it. Plants rely upon sunlight to generate chemical energy, which is stored in their tissues and fuels various life processes. In turn, animals like us convert the energy from the food that we eat into mechanical energy.  Furthermore, we depend upon light energy entering our eyes in order

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Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies

A-Synuclein, Biomarkers, Dementia - Lewy Bodies, Parkinson's Disease, Pre-PD /

The clinicopathological heterogeneity in Lewy-body diseases (LBD) highlights the need for pathology-driven biomarkers in-vivo. Misfolded alpha-synuclein (α-Syn) is a lead candidate based on its crucial role in disease pathophysiology. Real-time quaking-induced conversion (RT-QuIC) analysis of CSF has recently shown high sensitivity and specificity for the detection of misfolded α-Syn in patients with Parkinson’s disease (PD) and

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Microbiota in Health and Disease—Potential Clinical Applications

A-Synuclein, Butyrate, Diet and Exercise, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids, Vagal Nerve /

: Within the last two decades tremendous efforts in biomedicine have been undertaken tounderstand the interplay of commensal bacteria living in and on our human body with our ownhuman physiology. It became clear that (1) a high diversity especially of the microbial communitiesin the gut are important to preserve health and that (2) certain bacteria

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CORE ONE LABS’ AKOME SEEKS TO REVOLUTIONIZE TREATMENT OF PARKINSON’S DISEASE AND SUBMITS APPLICATION TO PROTECT IP

Ayahuasca, Parkinson's Disease, Pre-PD /

Akome’s AKO004 psychedelic drug formulation, for use in the treatment of Parkinson’s disease, is a composition comprising the psychedelic compound N,N-dimethyltryptamine (DMT) and, a specifically chosen, naturally occurring plant bioactive.  Initial data analysis indicates that the AKO004 composition is safe and efficacious for use, and presents many positive properties which may counter or mitigate neurodegeneration

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MISFOLDED α-SYN – FROM RELEASE AND UPTAKE TO CONTAGION OF ADJACENT CELL, ANY LINKS WITH GUT?

A-Synuclein, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

Alpha-synuclein(α-Syn) is an intracellular protein which is constantly synthesized and degraded underphysiological conditions. Abnormal aggregation of this protein within neuron is associated with severalneurodegenerative disorders, including Parkinson’s disease. Although the exact mechanism of initiation ofaggregation and misfolding pathway of a-Syn is yet to be discovered; it’s mechanism of spreading throughinterconnected neuronal networks has taken acompelling

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