Parkinson’s Disease

A novel multi-target strategy to attenuate the progression of Parkinson’s disease by diamine hybrid AGE/ALE inhibitor

A-Synuclein, Parkinson's Disease, Pre-PD /

Instead of a conventional ‘one-drug-one-target approach’, this article presents a novel multi-target approach with a concept of trapping simultaneously as many detrimental factors as possible involved in the progression of Parkinson’s disease. These factors include reactive carbonyl species, reactive oxygen species, Fe3+/Cu2+ and ortho-quinones (o-quinone), in particular. Different from the known multi-target strategies for Parkinson’s disease, […]

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Circulatory 25(OH)D and 1,25(OH)2D as differential biomarkers between multiple system atrophy and Parkinson’s disease patients

Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

There is sufficient evidence to support vitamin D’s noncalcemic effects and the role ofvitamin D deficiency in the development of a wide range of neurological disorders. This study aimed to evaluatewhether serum 25(OH)D and 1,25(OH) 2 D could be used as biomarkers to differentiate between healthy subjects(HS), multiple system atrophy (MSA) and Parkinson’s disease (PD)

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Mild Parkinsonian Signs: A Systematic Review of Clinical, Imaging, and Pathological Associations

Biomarkers, Parkinson's Disease, Pre-PD /

There are currently no consistent radiological findings for MPS, and pathological studies have shown that MPS, at least in the oldest old, are often underpinned by mixed neuropathologies, including those associated with Alzheimer’s disease, cerebrovascular disease, nigral neuronal loss, and Lewy bodies. Different subcategories of MPS appear to convey varying risk and specificity for PD

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Mitochondrial Dysfunction in a Mouse Model of Prodromal Parkinson’s Disease: A Metabolomic Analysis

Biomarkers, Mitochondria, Parkinson's Disease, Pre-PD /

For the development of disease-modifying therapies for Parkinson’s disease (PD) the identification of biomarkers in the prodromal stage is urgently required. Because PD is considered a systemic disease even in the early stage, we performed a metabolomic analysis of the plasma from a mouse model of prodromal PD (p-PD). Increased levels of isobutyrylcarnitine in p-PD

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Calcium channels and iron metabolism: A redox catastrophe in Parkinson’s disease and an innovative path to novel therapies?

Iron, Parkinson's Disease, Pre-PD /

Autonomously spiking dopaminergic neurons of the substantia nigra pars compacta (SNpc) are exquisitely specialized and suffer toxic iron-loading in Parkinson’s disease (PD). However, the molecular mechanism involved remains unclear and critical to decipher for designing new PD therapeutics. The long-lasting (L-type) CaV1.3 voltage-gated calcium channel is expressed at high levels amongst nigral neurons of the

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Heat Shock Proteins, Sauna, and Global Health Benefits

A-Synuclein, Parkinson's Disease /

What are Heat Shock Proteins? When cells are exposed to stressful situations, they respond by creating heat shock proteins. Since the first type of stress found to activate these proteins was heat, the proteins were named heat shock proteins.  Other triggers of heat shock proteins in the body include cold temperatures, ultraviolet light, heavy metals,

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Parkinson’s disease outside the brain: targeting the autonomic nervous system

A-Synuclein, Parkinson's Disease /

Patients with Parkinson’s disease present with signs and symptoms of dysregulation of the peripheral autonomic nervous system that can even precede motor deficits. This dysregulation might reflect early pathology and therefore could be targeted for the development of prodromal or diagnostic biomarkers. Only a few objective clinical tests assess disease progression and are used to

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Investigating Casual Associations among Gut Microbiota, Metabolites and Neurodegenerative Diseases: A Mendelian Randomization Study

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Metabolites, Parkinson's Disease /

Our study firstly applied a two-sample MR approach to detect causal relationships among gut microbiota, gut metabolites and the risk of AD, PD and ALS, andwe revealed several causal relationships. These findings may provide new targets for treatment of these neurodegenerative diseases, and may offer valuableinsights for further researches on the underlying mechanisms. In summary,

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A New Kind of Pathogen – The prion-like pathology of amyloid fibrils in Parkinson’s disease

A-Synuclein, Dementia - Lewy Bodies, Gut-Brain axis, Olfactory, Parkinson's Disease, Pre-PD, Vagal Nerve /

This chapter contrasts the prion-like behavior of alphasynuclein in Parkinson’s disease with other prion diseases.In prion diseases, the infectious, amyloid form of theprotein induces the corresponding normally folded proteinto assume the toxic fold, spreading the disease and slowlydestroying the brains of infected patients. Lewy pathologyin Parkinson’s disease appears to spread in a mannersimilar to that

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The effects of coffee consumption and antibiotic use on gut microbial community structure of Parkinson’s disease patients

Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease (PD) is a complex brain disorder involving a multitude ofcontributing factors ranging from environmental to genetic. Interestingly, it has been foundthat the gut microbial community is altered in PD patients when compared to that of non-PDindividuals. However, the factors contributing to altered gut microbiota remain largelyunexplored. As such, the first objective of our

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