Microbiota-targeted interventions such as personalized diet, probiotics, or fecal microbiota transplantation (FMT) might represent a potential therapeutic option for AD. This review article discusses the procedure of FMT and its possible side effects on the recipient’s body. In addition, we review the role of FMT in the context of its application in various nervous system-related […]
Studies show that short – chain fatty acids have differenteffects by increasing or decreasing the quantity of certain molecules such as GLP-1,peptide YY, insulin, glucagon, ghrelin, leptin and serotonin while they also have animpact on the nervous system. Also is needed to emphasize its role in certainneurological diseases such as Parkinson, autism spectrum disorder and
IMPACT OF THE SHORT – CHAIN FATTY ACIDS ON THE MICROBIOTA – GUT – BRAIN AXIS Read More »
Probiotic supplementation mediates these pharmacological effects by targeting a variety of cellular and molecular processes, i.e., oxidative stress, inflammatory and anti-inflammatory pathways, as well as apoptosis. Herein, we summarize the effects of probiotics on motor and non-motor symptoms as well as various cellular and molecular pathways in PD. CLICK TO REVIEW
Probiotics and the Treatment of Parkinson’s Disease: An Update Read More »
However, there is limited success in restoring healthy microbial biodiversity in AD and PD patients with general probiotics interventions and fecal microbial therapies. Fortunately, the gut microflora is susceptible to long-term extrinsic influences such as lifestyle and dietary choices, providing opportunities for treatment through comparatively individual-specific control of human behavior. In this review, weexamine the
One fundamental component of systemic homeostasis is the gut microbiota, which communicates withthe CNS via microbial metabolite production, the peripheral nervous system, and regulation oftryptophan metabolism. Over the past 10–15 years, research focused on the microbiota–gut–brainaxis has culminated in the discovery that dysbiosis, or an imbalance between commensal andpathogenic gut bacteria, can promote CNS pathologies.
Modulation of Neuroinflammation by the Gut Microbiota in Prion and Prion-Like Diseases Read More »
In the case of PD, the fact that the disease is accompanied by other non-motor symptoms in organs highly exposed to the environment (olfactory and gastrointestinal systems) reinforces the hypotheses of the role of environmental factors in the etiology of PD. Many chemicals such as pesticides, metals (iron and lead), polychlorinated biphenyls, solvents such as
We used the data from 10 randomly chosen patients from our cohort of FMT patients and the same for 10 randomly chosenpatients who had received GFRT. We measured their microbiomes using 16S mRNA tests, the results are shown in Tables 3 and 4. The reference values for the laboratory were used for these tests are
The presence of p-syn at any biopsy site was correlated with both sympathetic (CASS adrenergic r = 0.6, p < 0.05) and total autonomic impairment (CASS total r = 0.6, p < 0.05) on autonomic reflex testing in iRBD patients. These results were independent of the density of p-syn at each site. There was no
: The average life expectancy of the world population has increased remarkably in the past150 years and it is still increasing. A long life is a dream of humans since the beginning of time but also a dream is to live it in good physical and mental condition. Nutrition research has focused on recent decades
Impact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity Read More »
Parkinson’s disease (PD) is the most prevalent movement disorder known and predominantly affects the elderly. It is a progressive neurodegenerative disease wherein α-synuclein, a neuronal protein, aggregates to form toxic structures in nerve cells. The cause of Parkinson’s disease (PD) remains unknown. Intestinal dysfunction and changes in the gut microbiota, common symptoms of PD, are
Desulfovibrio Bacteria Are Associated With Parkinson’s Disease Read More »