Parkinson’s Disease

Cross-Reactivity and Sequence Homology Between Alpha-Synuclein and Food Products: A Step Further for Parkinson’s Disease Synucleinopathy

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Herbs & Spices, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The cross-reactivity and sequence homology between α-synuclein and frequently consumed foods, reinforces the autoimmune aspect of Parkinson’s disease. It is hypothesized that luminal food peptides that share cross-reactive epitopes with human α-synuclein and have molecular similarity with brain antigens are involved in the synucleinopathy. The findings deserve further confirmation by extensive research. CLICK TO REVIEW

Cross-Reactivity and Sequence Homology Between Alpha-Synuclein and Food Products: A Step Further for Parkinson’s Disease Synucleinopathy Read More »

A randomised controlled trial on effectiveness and feasibility of sport climbing in Parkinson’s disease

Biomarkers, Diet and Exercise, Parkinson's Disease, Pre-PD /

Physical activity is of prime importance in non-pharmacological Parkinson’s disease (PD) treatment. The current study examines the effectiveness and feasibility of sport climbing in PD patients in a single-centre, randomised controlled, semi-blind trial. A total of 48 PD patients without experience in climbing (average age 64 ± 8 years, Hoehn & Yahr stage 2–3) were assigned either

A randomised controlled trial on effectiveness and feasibility of sport climbing in Parkinson’s disease Read More »

Objective vowel sound characteristics and their relationship with motor dysfunction in Asian Parkinson’s disease patients

Parkinson's Disease, Pre-PD /

Our study provides objective evidence of phonatory dysfunction in Asian PD patients with certain characteristics correlated with advanced stage or different motor dysfunction. Sustained vowel phonation is a promising digital outcome for global phenotyping a large number of PD patients. CLICK TO REVIEW

Objective vowel sound characteristics and their relationship with motor dysfunction in Asian Parkinson’s disease patients Read More »

Gut Microbiome Changes with Osteopathic Treatment of Constipation in Parkinson’s Disease: A Pilot Study

Biomarkers, Parkinson's Disease, Pre-PD /

The gut microbiome appears to be predictive of Parkinson’s disease (PD) with constipation. Chronic constipation frequently manifests prior to motor symptoms and impairs quality of life. An osteopathic manipulative medicine (OMM) sequence used physical exam assessment and manual treatment of neuromusculoskeletal dysfunctions pertinent to constipation in PD for this prospective ABA-design study, IRB-NYITBHS1065. The effects

Gut Microbiome Changes with Osteopathic Treatment of Constipation in Parkinson’s Disease: A Pilot Study Read More »

The gut microbiome: implications for neurogenesis and neurological diseases

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Short Chain Fatty Acids /

The gut microbiome has also gained increasing attention in PD, and its involvement has been strongly implicated in the modulation of this disease. Microbiota analysis has revealed increased Enterobacteria and decreased Prevotella strains in patients with PD (Scheperjans et al., 2015). Another clinical study found that, compared with healthy controls, patients with PD exhibited decreases in a range of

The gut microbiome: implications for neurogenesis and neurological diseases Read More »

α-Synuclein Deposition in Sympathetic Nerve Fibers in Genetic Forms of Parkinson’s Disease

A-Synuclein, Parkinson's Disease /

Individuals with SNCA, DJ-1, LRRK2, or GBA mutations have substantial intraneuronal α-syn deposition in sympathetic noradrenergic nerves in skin biopsies, whereas those with biallelic PRKN mutations do not. Biallelic PRKN patients may have mildly increased α-syn deposition compared with control subjects. © 2021 International Parkinson and Movement Disorder Society. CLICK TO REVIEW

α-Synuclein Deposition in Sympathetic Nerve Fibers in Genetic Forms of Parkinson’s Disease Read More »

Deciphering and manipulating the epigenome for the treatment of Parkinson’s and Alzheimer’s disease

Biomarkers, Parkinson's Disease /

This narrative review aimed to elaborate on the potential epigenomic treatments for PD and AD. About 199 scientific articles written in English, which reported on novel epigenomic-based treatment for PD and AD, were selected for this review from the PubMed database. Full articles and relevant data were extracted. Treatments targeting DNA methylation or miRNAs appear

Deciphering and manipulating the epigenome for the treatment of Parkinson’s and Alzheimer’s disease Read More »

Identification of leaky gut-related markers as indicators of metabolic health in Dutch adults: The Nutrition Questionnaires plus (NQplus) study

Biomarkers, Gut Dysbiosis, Gut Permeability / Leaky Gut, Lipopolysaccharides (LPS), Parkinson's Disease, Pre-PD, Zonulin /

Biomarkers that link a leaky gut and subsequent bacterial translocation to metabolic health were identified in this study. Especially zonulin may aid in monitoring a leaky gut and detecting individuals at risk for developing chronic metabolic diseases. CLICK TO REVIEW

Identification of leaky gut-related markers as indicators of metabolic health in Dutch adults: The Nutrition Questionnaires plus (NQplus) study Read More »

Retinal thickness and microvascular pathway in Idiopathic Rapid eye movement sleep Behaviour Disorder and Parkinson’s disease

iRBD, Parkinson's Disease, Pre-PD /

In PD and iRBD patients retina was thinner than HCs, and values of iRBD were between PD and HCs. Moreover, in iRBD, a peculiar microvascular pattern has been found, characterized by a higher vascularization of the deep capillary plexus. Our findings suggest that retina might be considered a biomarker of neurodegeneration in iRBD, easily estimable

Retinal thickness and microvascular pathway in Idiopathic Rapid eye movement sleep Behaviour Disorder and Parkinson’s disease Read More »