Parkinson’s Disease

The Potential Role of Cinnamon in Human Health

Parkinson's Disease, Pre-PD /

In folk medicine, cinnamon species have been used as medicine for respiratory and digestive disorders. Their potential for prophylactic and therapeutic use in Parkinson’s and Alzheimer’s disease has also been discovered. This review summarizes the available isolation methods and analytical techniques used to identify biologically active compounds present in cinnamon bark and leaves and the […]

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Serum metabolic biomarkers for synucleinopathy conversion in isolated REM sleep behavior disorder

A-Synuclein, Biomarkers, iRBD, Parkinson's Disease, Pre-PD /

Our results indicate that metabolic alterations and inflammation are involved in iRBD pathophysiology, and suggest biological differences underlying the progression of LTS in iRBD patients. Our data also indicate that profiling of serum samples by NMR may be a useful tool for identifying short-term high-risk iRBD patients for conversion to parkinsonism or dementia. CLICK TO

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Neurological disorders associated with impaired gut microbiota

Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Proinflammatory mediators such as iNOS, ROS, COX2 and NF-B are released by microglia, resulting in neuroinflammation in Alzheimer’s disease. It is becoming more widely recognized as a symptom of Autism Spectrum Disorder. The establishment of gut-brain psychology is expected to have a significant impact on psychology and related disciplines. CLICK TO REVIEW

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Air pollution, surrounding green, road proximity and Parkinson’s disease: A prospective cohort study

Parkinson's Disease /

We found that PM2.5 were associated with increased risk of incident PD while surrounding green was associated with decreased risk of PD. Future studies about PD etiology may benefit from including multiple environmental exposures to address potential joint associations. CLICK TO REVIEW

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Neuronal Autophagy: Characteristic Features and Roles in Neuronal Pathophysiology

Autophagy, Parkinson's Disease /

Autophagy is an important degradative pathway that eliminates misfolded proteins and damaged organelles from cells. Autophagy is crucial for neuronal homeostasis and function. A lack of or deficiency in autophagy leads to the accumulation of protein aggregates, which are associated with several neurodegenerative diseases. Compared with non-neuronal cells, neurons exhibit rapid autophagic flux because damaged

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The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline

A-Synuclein, Gut-Brain axis, Parkinson's Disease /

Consequently, the initial α-synuclein pathology inside the CNS is more symmetric, which promotes more symmetric propagation in the brainstem, leading to more symmetric dopaminergic degeneration and less motor asymmetry. At diagnosis, body-first patients already have a larger, more symmetric burden of α-synuclein pathology, which in turn promotes faster disease progression and accelerated cognitive decline. The

The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline Read More »

Association of small intestinal bacterial overgrowth with Parkinson’s disease: a systematic review and meta-analysis

Gut Dysbiosis, Parkinson's Disease, Pre-PD /

Our meta-analysis identified a strong association between SIBO and PD with approximately half of PD patients testing positive for SIBO. These relationships were significantly different according to type of diagnostic test and geographic area. Therefore, we must pay close attention to enteric microorganisms to prevent nervous system diseases. CLICK TO REVIEW

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Microbiota-derived short chain fatty acids modulate microglia and promote Ab plaque deposition

Gut Microbiota, Parkinson's Disease, Short Chain Fatty Acids /

Despite increased microglial recruitment to Ab plaques upon SCFA supplementation, microglia contained less intracellular Ab. Taken together, our results demonstrate that microbiota-derived SCFA are critical mediators along the gut-brain axis which promote Ab deposition likely via modulation of the microglial phenotype. CLICK TO REVIEW

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Natural polyphenols in central nervous system disorders

Parkinson's Disease, Polyphenols, Vitamins / Supplements / Nutraceuticals /

Reduced oxidative stress causes the suppression of the risk of associated neurodegenerative diseases, such as, Alzheimer’s disease (AD), stroke, multiple sclerosis (MS), Parkinson’s disease (PD) and Huntington’s disease (HD). Consequently, the analysis indicates that polyphenol beneficial effects on human brain activity and this review describe these implications by discussing the latest mechanistic hypothesis. CLICK TO

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Toward Precision Medicine: Effects of the Common VAL66met BDNF Variant in the Aging Brain and Implications for the Future of Parkinson’S Disease Therapeutics

Parkinson's Disease, Therapies /

In this rapidly evolving era of precision medicine, understanding mechanisms underlying the beneficial versus detrimental impact of the Val66Metpolymorphism, and/or its interaction with aging, will aid in the development of safe and optimized therapeutic approaches for remodeling the parkinsonian striatum. CLICK TO REVIEW

Toward Precision Medicine: Effects of the Common VAL66met BDNF Variant in the Aging Brain and Implications for the Future of Parkinson’S Disease Therapeutics Read More »