Parkinson’s Disease

Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models

Anti-oxidants, Parkinson's Disease, Pre-PD /

Therefore, the use of natural antioxidants in PD may provide an alternative therapy that prevents oxidative stress and reduces disease progression. In this review, the effects of hydroxytyrosol, Ginkgo biloba, Withania somnifera, curcumin, green tea, and Hypericum perforatum in PD animal and cell line models are compared and discussed. The reviewed antioxidants show evidence of protecting neural cells from […]

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Investigating the Putative Mechanisms Mediating the Beneficial Effects of Exercise on the Brain and Cognitive Functions

Diet and Exercise, Parkinson's Disease, Pre-PD /

A variety of brain disorders including alzheimer’s disease, parkinson’s disease, chronic stress, age-related cognitive decline, psychological disorders have been revealed to avoid, restore, or improve by different procedures of physical exercise. CLICK TO REVIEW

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Alpha-synuclein preformed fibrils: a tool to understand Parkinson’s disease and develop disease modifying therapy

A-Synuclein, Biomarkers, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by multiple motor and non-motor symptoms, which include, among others, constipation, sleep disturbance, bradykinesia, gait and balance abnormalities, muscle stiffness and resting tremor. The motor symptoms are caused by progressive age-related death of dopaminergic neurons and in the vast majority of patients suffering from

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Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease

Iron, Parkinson's Disease, Pre-PD /

The highest cellular iron levels in neurons were located in the cytoplasm, which might increase the source of non-chelated Fe3+, implicating a critical increase in the labile iron pool. Indeed, neuromelanin is characterized by a significantly higher loading of iron including most probable the occupancy of low-affinity iron binding sites. Quantitative trace element analysis is

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The cell biology of Parkinson’s disease

A-Synuclein, Parkinson's Disease /

Parkinson’s disease (PD) is a progressive neurodegenerative disorder resulting from the death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD biology has been enriched by the identification of genes involved in its rare, inheritable forms, termed PARK genes. These genes encode proteins including α-syn, LRRK2, VPS35, parkin, PINK1, and DJ1, which can

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Nutritional aspects in Parkinson’s disease

Biomarkers, Diet and Exercise, Parkinson's Disease, Pre-PD /

The links between diet and Parkinson’s disease (PD) are unclear and incomprehensible. However, numerous studies have demonstrated the correlation between diet, nutrients and health condition in PD patients. They indicate the possibility of management of the disease, which might be possible through nutrition. Pharmaceutical treatment as well as a complementary holistic approach to the patients

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Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease

Biomarkers, iRBD, Parkinson's Disease, Pre-PD /

Patients diagnosed with iRBD are characterized by poor global cognitive performance, but better long-term memory and higher levels of depression, anxiety, alexithymia and apathy. Alexithymia and apathy in patients diagnosed with iRBD may be the expression of precocious derangement of emotional regulation, subsequently observed also in PD. Cognitive and neuropsychiatric symptoms of iRBD are early

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Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease

Parkinson's Disease /

Recently, the protective effects of sulforaphane on brain health were also considerably studied, where the studies have further extended to severalneurological diseases, including Alzheimer’s disease (AD), Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, autism spectrum disorder, and schizophrenia. Animal and cell studies that employ sulforaphane against memory impairment and AD related pre-clinical biomarkers

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Effect of Care Rehabilitation on Medical Expenses, Care Costs, and Total Costs of Elderly Individuals with Parkinson’s Disease

Parkinson's Disease /

The fast-growing prevalence of Parkinson’s disease (PD) creates a heavy burden for society and the health care system. Although different ways to mitigate the economic burden of PD have been discussed in the literature, including several effective treatments, few studies have paid attention to the effect of care rehabilitation (CR) on PD costs over a

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