The Aligning Science Across Parkinson’s (ASAP) initiative was set up to improve understanding of the biology underlying the onset and progression of Parkinson’s disease. With an emphasis on open science and collaboration, we have assembled a research network led by nearly 100 investigators to explore the pathology of Parkinson’s disease, and this network will soon […]
Point of View: Open science takes on Parkinson’s disease Read More »
Parkinson’s disease (PD) is among the most common chronic neurodegenerative conditions, affecting 1% of those over 60 years of age, and involves motor and non-motor impairments. Alterations in normal physiology may become apparent years – in some cases, 10–20 years – before established diagnostic criteria are met. Thus, better clinical outcomes may result when practitioners
Parkinson’s Disease: Possible Mechanisms for Nutritional Approaches Read More »
Distinct PA profiles, with clear differences in how the time awake is spent exist among people with mild-moderate PD. CLICK TO REVIEW
Physical activity profiles in Parkinson’s disease Read More »
Adults with Parkinson’s disease (PD) experience debilitating symptoms that may be mitigated by boxing. Yet, attrition from boxing programs is problematic. Understanding whether PD-specific boxing programs can enhance motivation to remain physically active is important. This study investigated adults’ experiences within a PD-specific boxing program and explored their perspectives on how the program has influenced
: Sleep microstructure is more severely altered than sleep macrostructure in PDpatients and is associated with widespread dysfunction of the noradrenergic arousal system. CLICK TO REVIEW
Conclusion: Distinct PA profiles, with clear differences in how the time awake is spent exist among people withmild-moderate PD. CLICK TO REVIEW
Physical activity profiles in Parkinson’s disease Read More »
In this case, the field study and epidemiological results supported the work-relatedness of PD and exposure to pesticides. Moreover, the results of previous studies have confirmed a causal relationship between exposure to pesticides and PD. CLICK TO REVIEW
Parkinson’s disease in a worker exposed to insecticides at a greenhouse Read More »
In addition, in vitro and in vivo studies have shown that cinnamon extracts may affect the oligomerization process and aggregation of α‐synuclein. Herein, we discuss recent evidence on the novel therapeutic opportunities of this phytochemical against PD, indicating additional mechanistic aspects that should be explored, and potential obstacles/limitations that need to be overcome, for its
The presence of olfactory dysfunction conveys a considerably elevated risk of incident PD, likely more in studies with a higher proportion of women, older individuals or short follow-up duration. Individual patient data are warranted to confirm these findings and to yield subgroup-specific risk estimates of other common markers to refine prodromal PD criteria. CLICK TO
This review will focus on the most promising marine drugs’ neuro-protective potential for neuro-degenerative disorders, such as Parkinson’s and Alzheimer’s diseases. We will describe these marine compounds’ potential as adjuvant therapies for neuro-degenerative diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties. CLICK TO REVIEW
Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders Read More »