Bacterial metabolites/proteins can also reduce ɑ-synuclein aggregation in vitro CLICK TO REVIEW POSTER
Strain-level meta-analysis of Parkinson’s disease-associated gut microbiome Read More »
The Mediterranean diet has been associated with the risk of Parkinson’s disease (PD),but limited research has been performed on other dietary patterns. We studied the relationshipbetween overall diet quality and PD risk in the general population. We included 9414 participantsfrom the Rotterdam Study, a prospective population-based study in the Netherlands. Diet wasdefined using a Dutch
Diet Quality and Risk of Parkinson’s Disease: The Rotterdam Study Read More »
Video-polysomnography (v-PSG) is essential for diagnosing rapid eye movement (REM)sleep behavior disorder (RBD). Although there are current American Academy of SleepMedicine standards to diagnose RBD, several aspects need to be addressed to achieveharmonization across sleep centers. Prodromal RBD is a stage in which symptoms andsigns of evolving RBD are present, but do not yet meet
Sleep disturbance has been reported in up to 88%–98% of Parkinson’s disease patients; various sleep disorders can present even before motor symptoms. Rapid eye movement sleep behavior disorder (RBD), which can lead to violent dream enactment behavior, has a prevalence in Parkinson’s disease of 20% to 50% but best management of the condition is unclear.
Melatonin as first-line treatment for sleep disorders in Parkinson’s disease? Read More »
Constipation is the most predominant symptom of Parkinson disease (PD), preceding the occurrence of motor symptoms in some patients, leading to reduced quality of life (QOL). The general approaches for the treatment have some side effects, but probiotics are live or attenuated microorganisms attributed to ameliorating constipation effects. Moreover, as treatments are generally well tolerated and side
The clinicopathological heterogeneity in Lewy-body diseases (LBD) highlights the need for pathology-driven biomarkers in-vivo. Misfolded alpha-synuclein (α-Syn) is a lead candidate based on its crucial role in disease pathophysiology. Real-time quaking-induced conversion (RT-QuIC) analysis of CSF has recently shown high sensitivity and specificity for the detection of misfolded α-Syn in patients with Parkinson’s disease (PD) and
: Within the last two decades tremendous efforts in biomedicine have been undertaken tounderstand the interplay of commensal bacteria living in and on our human body with our ownhuman physiology. It became clear that (1) a high diversity especially of the microbial communitiesin the gut are important to preserve health and that (2) certain bacteria
Microbiota in Health and Disease—Potential Clinical Applications Read More »
Akome’s AKO004 psychedelic drug formulation, for use in the treatment of Parkinson’s disease, is a composition comprising the psychedelic compound N,N-dimethyltryptamine (DMT) and, a specifically chosen, naturally occurring plant bioactive. Initial data analysis indicates that the AKO004 composition is safe and efficacious for use, and presents many positive properties which may counter or mitigate neurodegeneration
Plasma GSH was associated with pPD probability trajectories; therefore, it might assist in the identification of individuals who are likely to reach the threshold for pPD diagnosis more rapidly. CLICK TO REVIEW
Plasma Glutathione and Prodromal Parkinson’s Disease Probability Read More »
Objective and background The objectives were to compare periodontal status between subjects with and without Parkinson’s disease (PKD) to determine the influence of PKD on periodontal disease. This study was conducted to evaluate the relationship of periodontal status with severity of PKD. Conclusion There is a need for dental care and encouragement to use plaque