Pre-PD

Impact of environmental toxicants exposure on gut-brain axis in Parkinson disease

A-Synuclein, Enviromental, Gut Dysbiosis, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Parkinson disease (PD) is a major public health challenge as many of the current drugs used in its management provide symptomatic relieve without preventing the underlying cause of the neurodegeneration. Similarly, the non-motor complications of PD, especially the gastrointestinal tract (GIT) disturbance increases the disease burden on both the PD patient and caregivers. Different theories […]

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Chaperone-Mediated Autophagy in Neurodegenerative
Diseases and Acute Neurological Insults in the Central
Nervous System

Autophagy, Parkinson's Disease, Pre-PD /

Autophagy is an important function that mediates the degradation of intracellular proteinsand organelles. Chaperone-mediated autophagy (CMA) degrades selected proteins and has a crucialrole in cellular proteostasis under various physiological and pathological conditions. CMA dysfunction leads to the accumulation of toxic protein aggregates in the central nervous system (CNS) andis involved in the pathogenic process of

Chaperone-Mediated Autophagy in Neurodegenerative
Diseases and Acute Neurological Insults in the Central
Nervous System Read More »

Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progression

iRBD, Parkinson's Disease, Pre-PD /

The course of REM sleep behavior disorder (RBD) variates in the early stage of Parkinson’s disease. We aimed to delineate the association between the evolution pattern of probable RBD (pRBD) and the progression of Parkinson’s disease (PD). 281 de novo PD patients from the Parkinson’s Progression Markers Initiative database were included. Patients were followed up

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Facts and controversies regarding oral health in Parkinson’s disease:
A case-control study in Spanish patients

Diet and Exercise, endondonics, Oral Microbiome, Parkinson's Disease, Pre-PD, Root Canal /

Oral disorders are frequent in PD. Good knowledge of these alterations will allow us to design a specific preventive protocol. Some oral alterations may be a sign of diagnostic alert or progression of PD. CLICK TO REVIEW

Facts and controversies regarding oral health in Parkinson’s disease:
A case-control study in Spanish patients Read More »

Gut microbiota and inflammation in
Parkinson’s disease: Pathogenetic and
therapeutic insights

A-Synuclein, Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuronal loss andα-synuclein (α-syn) aggregation. With the acceleration of population aging process, the incidence of PD is expected toincrease, putting a heavy burden on the whole society. Recent studies have found the alterations of gut microbiota (GM) inPD patients and the clinical relevance of

Gut microbiota and inflammation in
Parkinson’s disease: Pathogenetic and
therapeutic insights Read More »

The potential applications of traditional Chinese medicine in Parkinson’s disease: A new opportunity

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Parkinson’s disease (PD) presents a common challenge for people all over the world and has become a major research hotspot due to the large population affected by the illness and the difficulty of clinical treatment. The prevalence of PD is increasing every year, the pathogenesis is complex, and the current treatment is ineffective. Therefore, it has

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Lipopolysaccharide mouse models for Parkinson’s disease research

Lipopolysaccharides (LPS), Parkinson's Disease, Pre-PD /

a critical appraisal Parkinson’s disease, the most common movement disorder, has a strong neuroinflammatory aspect. This is evident by increased pro-inflammatory cytokines in the serum, and the presence of activated microglial cells, and inflammatory cytokines in the substantia nigra of post-mortem brains as well as cerebrospinal fluid of Parkinson’s disease patients. The central and peripheral

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Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases

Anti-oxidants, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The global prevalence of Alzheimer’s disease and Parkinson’s disease is steadily increasing due to the aging population. The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment. Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may

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Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson’s disease

A-Synuclein, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is a multifocal degenerative disorder for which there is no cure. The majority of cases are sporadic with unknown etiology. Recent data indicate that untreated patients with de novo PD have increased colonic permeability and that both de novo and premotor patients have pathological expression of α-synuclein (α-syn) in their colon. Both

Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson’s disease Read More »