Pre-PD

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management

Gut Dysbiosis, Gut-Brain axis, Parkinson's Disease, Pre-PD /

The identification of Parkinson’s disease (PD) is mainly dependent on motorsymptoms, while the non-motor symptoms exist even decades ahead of the PDdiagnosis. According to Braak’s hypothesis, the enteric plexus is the first affectedsite during the pathological development of PD, and gastrointestinal (GI) symptomsappear during the onset of the disease. Although GI symptoms decrease the lifequality […]

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management Read More »

The Role of Gut Microbiome and Dysbiosis in Common Psychological,
Neurological, and Behavioral Disorders

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD /

According to psychobiotic research expansion, the gut microbiome—a colony of more than 1000 species—is connected to brainhealth and state of mind. Historically, even though a variety of body parts and systems were linked to the nervous system in thenineteenth century, researchers began began researching the gut, especially the stomach, calling it ‘the great abdominal brain’,

The Role of Gut Microbiome and Dysbiosis in Common Psychological,
Neurological, and Behavioral Disorders Read More »

THE MICROBIOTA-GUT-BRAIN AXIS

A-Synuclein, Butyrate, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However,the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms withinand on our bodies) as one of the key regulators of gut-brain function and has led to the appreciationof the importance of a distinct microbiota-gut-brain axis.This axis

THE MICROBIOTA-GUT-BRAIN AXIS Read More »

Dietary Inflammatory Index score and prodromal Parkinson’s disease incidence: The HELIAD study

Diet and Exercise, Parkinson's Disease, Pre-PD /

The aim of the present study was to investigate the association of the inflammatory potential of diet with prodromal Parkinson’s disease (pPD) probability and incidence among community-dwelling older individuals without clinical features of parkinsonism at baseline. More pro-inflammatory diet was related with higher pPD probability and pPD incidence (pPD probability ≥30%) in a community-dwelling older

Dietary Inflammatory Index score and prodromal Parkinson’s disease incidence: The HELIAD study Read More »

Brain-Gut-Microbiota Axis in Schizophrenia and Parkinson’s
Disease

Gut Dysbiosis, Gut-Brain axis, Parkinson's Disease, Pre-PD, Vagal Nerve /

Dopaminergic cells, which use dopamine as a neurotransmitter, arenot as numerous as other brain nerve cells such as serotonergic andGABAergic neurons. However, dopamine neurons project to a varietyof important brain regions to control movement, emotion, the rewardsystem, and the secretion of prolactin. Both schizophrenia andParkinson’s disease are disorders of the dopaminergic neurotransmissions, but schizophrenia has

Brain-Gut-Microbiota Axis in Schizophrenia and Parkinson’s
Disease Read More »

Sleep Disorders and Autonomic Nervous System Dysfunction

iRBD, Pre-PD /

Parasympathetic nervous system activity dominates during non-rapid eye movement (REM) sleep, whereas the sympathetic nervous system is dominant during REM sleep. The balance between the sympathetic and parasympathetic nervous systems reduces the heart rate and blood pressure during non-REM sleep and increases these parameters during REM sleep and wakefulness. Heart rate variability analysis, a non-invasive

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ORAL BUTYRATE AND MICROBIOTA-TARGETED TREATMENTS FOR PARKINSON’S
DISEASE: EFFICACY STUDIES IN TRANSGENIC MICE.

A-Synuclein, Biomarkers, Butyrate, Gut Microbiota, Gut-Brain axis, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Current pharmacological treatments for Parkinson’s disease (PD) provide relief for motorsymptoms but fail to alleviate prevalent non-motor symptoms (NMS)- such as gastrointestinal(GI) dysfunction which often occurs before the development of motor symptoms. Strategies toslow the progression of PD have been proposed, but so far none has proven successful. PDpatients display changes in gut microbiome composition

ORAL BUTYRATE AND MICROBIOTA-TARGETED TREATMENTS FOR PARKINSON’S
DISEASE: EFFICACY STUDIES IN TRANSGENIC MICE. Read More »

The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: a randomized controlled trial

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Our findings support a mediating role of the gut microbiome in the beneficial effects of the Green-MED diet enriched with Mankai and green tea on cardiometabolic risk factors. CLICK TO REVIEW

The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: a randomized controlled trial Read More »

Impact of Probiotic and Prebiotic on Gut Microbiota in Pre-diabetes and Type 2 Diabetes

Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The increased worldwide prevalence of pre-diabetes and diabetes, especially type 2 diabetes, requiring different strategies for their prevention and management. A new focus is the reversal of diabetes dysbiosis, a disruption of gut microbiota homeostasis, which is closely related to elevated blood glucose levels and altered metabolic parameters. In this sense, a balanced diet plays a key role, and,

Impact of Probiotic and Prebiotic on Gut Microbiota in Pre-diabetes and Type 2 Diabetes Read More »

Inflammation and immune dysfunction in Parkinson disease

Gut Microbiota, Parkinson's Disease, Pre-PD /

Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral organs as well as the central nervous system and involves a fundamental role of neuroinflammation in its pathophysiology. Neurohistological and neuroimaging studies support the presence of ongoing and end-stage neuroinflammatory processes in PD. Moreover, numerous studies of peripheral blood and cerebrospinal fluid from patients

Inflammation and immune dysfunction in Parkinson disease Read More »