Pre-PD

Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration

A-Synuclein, Gut Dysbiosis, Gut Microbiota, Lipopolysaccharides (LPS), Oral Microbiome, Parkinson's Disease, Pre-PD /

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Creutzfeldt–Jakob disease (CJD) are brain conditions affecting millions of people worldwide. These diseases are associated with the presence of amyloid-β (Aβ), alpha synuclein (α-Syn) and prion protein (PrP) depositions in the brain, respectively, which lead to synaptic disconnection and subsequent progressive neuronal death. Although […]

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Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson’s diseas

A-Synuclein, Biomarkers, Parkinson's Disease, Pre-PD /

The proximity ligation assay (PLA) is a specific and sensitive technique for the detection of αSyn oligomers (αSyn-PLA), early and toxic species implicated in the pathogenesis of PD. We aimed to evaluate by skin biopsy the diagnostic and prognostic capacity of αSyn-PLA and small nerve fiber reduction in PD in a longitudinal study. αSyn-PLA was

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Gut Microbiota-Brain Interaction with Special Reference to Alzheimer’s Disease

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Gut microbiota is showing and raising evidence that the dynamic changes in the gut microorganism can influence physiology and behavior of brain. Dysbiosis or dysbacteriosis is a condition of microbial imbalance inside the intestinal microbiome. It has been associated with disorders of intestinal and extra‐intestinal such as inflammatory bowel disease and other multiple diseases like

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The link between the gut microbiota and Parkinson’s Disease: A systematic mechanism review with focus on α-synuclein transport

A-Synuclein, ENS, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Pre-PD /

Research has suggested a link between the gut microbiota and Parkinson’s Disease (PD), and an early involvement of gastrointestinal dysfunction has been reported in patients. A mechanism review was performed to investigate whether the neurodegenerative cascade begins in the gut; mediated by gut dysbiosis and retrograde transport of α-synuclein. This review provides a summary of

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What is leaky gut? Or… what? You can’t even eat HUMMUS?

Gut Dysbiosis, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD /

So what is intestinal permeability? Intestinal permeability (aka ‘leaky gut’) is the condition where the tight junctions on the lining of the intestine loosen, allowing undigested food particles, environmental toxins, foreign bacteria, and other normally restricted molecules to cross the gut barrier and migrate to other parts of the body. Normally, our intestines push molecules

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Effects of probiotic supplementation on intestinal tight junctions in a mouse model of Parkinson’s disease

Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease (PD) is a neurological disease impacting over six million people in the world. In addition to the motor symptoms of the disease, the disorder is accompanied with gastrointestinal problems. These include delayed transit time, disturbances in the microbial composition of the gut, inflammation in the intestine, structural changes in the epithelial lining and

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Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies

A-Synuclein, iRBD, Parkinson's Disease, Pre-PD /

Several studies have confirmed α-synuclein real-time quaking-induced conversion (αSyn-RTQuIC) assay to have high sensitivity and specificity for Parkinson’s disease. However, whetherthe assay can be used as a robust, quantitative measure to monitor disease progression, stratifydifferent synucleinopathies and predict disease conversion in patients with idiopathic REMsleep behaviour disorder remains undetermined. The aim of this study was

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Nocturnal Teeth Grinding Linked With Incidence of Other Sleep-Related Disorders

iRBD, Parkinson's Disease, Pre-PD /

SB is more prevalent in patients with the previously mentioned disorders than in the general population. Sleep arousal may be a common factor with which all the identified disorders are associated, except RBD and Parkinson’s disease. The associations between SB and these identified sleep-related disorders call for more SB screening in patients with the above mentioned

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Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease

Autophagy, Parkinson's Disease, Pre-PD /

Cellular quality control systems have gained much attention in recent decades. Amongthese, autophagy is a natural self-preservation mechanism that continuously eliminates toxic cellularcomponents and acts as an anti-ageing process. It is vital for cell survival and to preserve homeostasis.Several cell-type-dependent canonical or non-canonical autophagy pathways have been reportedshowing varying degrees of selectivity with regard to

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THE GUT-BRAIN AXIS: THE ROLE OF NUTRITION

Diet and Exercise, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The gut-brain axis (GBA) refers to the bi-directional communication thatoccurs between the gut and the brain. Recently, studies have highlightedthe important role of nutrition in modulating the GBA. We will delve into thisexciting area of research and understand how certain diets and foods maybe linked to mood and mental health. Our understanding of the gut-brain

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