Pre-PD

Correlations with REM sleep behavior disorder severity in isolated rapid eye movement sleep behavior disorders patients

Objectives: The pathogenesis of isolated rapid eye movement sleep behavior disorders (iRBD) is poorly understood. The severity of RBD may reflect its pathogenesis. Methods: We compared motor function and non-motor symptoms (NMSs) between iRBD patients and healthy volunteers. We correlated motor function, NMSs, and striatal dopaminergic activity with RBD severity using video-polysomnography. Results: Twenty-one iRBD […]

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Bioactive lipids and their metabolism: new therapeutic opportunities for Parkinson’s disease

Parkinson’s disease (PD) is a neurological disorder characterized by motor dysfunction, which can also be associated with non-motor symptoms. Its pathogenesis is thought to stem from a loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of Lewy bodies containing aggregated α-synuclein. Recent works suggested that lipids might play a pivotal

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α-Synuclein aggregation in the olfactory bulb induces olfactory deficits by perturbing granule cells and granular–mitral synaptic transmission

Olfactory dysfunction is an early pre-motor symptom of Parkinson’s disease (PD) but the neural mechanisms underlying this dysfunction remain largely unknown. Aggregation of α-synuclein is observed in the olfactory bulb (OB) during the early stages of PD, indicating a relationship between α-synuclein pathology and hyposmia. Here we investigate whether and how α-synuclein aggregates modulate neural

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The role of probiotics in nutritional health: probiotics as nutribiotics

The gut microbiota has gained importance through the years due to its significant influences on the maintenance of human health. A wide variety of microorganisms shape this gut microbiota, which preserves health with the modulation of the immune system, enhancement of the nutrients absorption, or the protection against pathogens’ colonization. The disruption of this microenvironment

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Composition of intestinal flora affects the risk relationship between Alzheimer’s disease/Parkinson’s disease and cancer

An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer’s disease/Parkinson’s disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer,

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Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models

Parkinson’s disease (PD) is a neurodegenerative disordercharacterized by a progressive loss of dopaminergic neu-rons in the substantia nigra (SN). The present study wasdesigned to examine the therapeutic effect of hydrogensulfide (H2S, a novel biological gas) on PD. The endoge-nous H2S level was markedly reduced in the SN in a6-hydroxydopamine (6-OHDA)-induced PD rat model. Sys-temic administration

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Plant derived bioactive compounds and their potential to enhance adult neurogenesis

Self-renewal and proliferation of neural progenitor cells occur throughout humans’ lives. However, aging, stress, and degenerative diseases can hinder or stop the process. If you can accelerate neurogenesis in adults, this is a promising way to recover from neurodegeneration and cognitive impairments. As the demand for a safer and natural therapeutic product has increased over

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The role of cardiovascular autonomic failure in the differential diagnosis of α-synucleinopathies

The α-synucleinopathies comprise a group of adult-onset neurodegenerative disorders including Parkinson’s disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB,) and — as a restricted non-motor form — pure autonomic failure (PAF). Neuropathologically, the α-synucleinopathies are characterized by aggregates of misfolded α-synuclein in the central and peripheral nervous system. Cardiovascular autonomic failure is

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Dual role of microbiota-derived short-chain fatty acids on host and pathogen

A growing body of documents shows microbiota produce metabolites such as short-chain fatty acids (SCFAs) as crucial executors of diet-based microbial influence the host and bacterial pathogens. The production of SCFAs depends on the metabolic activity of intestinal microflora and is also affected by dietary changes. SCFAs play important roles in maintaining colonic health as

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