A good diet may deliver micronutrients such as vitamins A, B6, B12, C,and D and minerals such as iron, copper, zinc, and selenium that have beenimplicated to have key roles for supporting immunity with reducing host infections.Most studies have shown that once the subject was infected, the immune system willbe enhanced, which will require high […]
Gut–Brain Cross Talk: Microbiome
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Inulin consumption in both humans and animal models is recognized for its prebiotic action with the most consistent change that lies in enhancing the growth and functionality of Bifidobacterium bacteria, as well as its effect on host gene expression and metabolism. Further, inulin-type fructans are utilized in the colon by bacterial fermentation to yield short-chain fatty acids (SCFAs), which play
Environmental exposure to glyphosate and glyphosate-based herbicides has the potential to negatively influence neurodevelopment and behavior across generations indirectly through the gut-brain-microbiome axis. Potential mechanisms by which glyphosate may elicit these effects are through the disruption of the normally symbiotic relationship of the host and the gut microbiome. Given glyphosate can kill commensal members of
: Leaky gut syndrome is a medical condition characterized by intestinal hyperpermeability.Since the intestinal barrier is one of the essential components maintaining homeostasis along thegastrointestinal tract, loss of its integrity due to changes in bacterial composition, decreased expression levels of tight junction proteins, and increased concentration of pro-inflammatory cytokinesmay lead to intestinal hyperpermeability followed by
: The human lifespan has been significantly increased due to scientific advancements inthe management of disease; however, the health span of the aging population does not follow thesame trend. Aging is the major risk factor for multimorbidity that is derived from the progressiveloss of homeostasis, immunological and stem cell exhaustion, as well as exacerbated inflammationresponses.
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuronal loss andα-synuclein (α-syn) aggregation. With the acceleration of population aging process, the incidence of PD is expected toincrease, putting a heavy burden on the whole society. Recent studies have found the alterations of gut microbiota (GM) inPD patients and the clinical relevance of
Parkinson’s disease (PD) presents a common challenge for people all over the world and has become a major research hotspot due to the large population affected by the illness and the difficulty of clinical treatment. The prevalence of PD is increasing every year, the pathogenesis is complex, and the current treatment is ineffective. Therefore, it has
The gut microbiota is composed of several microbial strains, with diverse and variablecombinations in healthy and sick persons, changing at different stages of life. A healthy balancebetween host and gut microorganisms must be maintained in order to perform the normal physiological, metabolic, and immune functions and prevent disease development. Disturbances in the balanceof the gut
The substantially increased prevalence of obesity and obesity-relateddiseases has generated considerable concern. Currently, synthetic biological strategieshave played an essential role in preventing and treating chronic diseases such as obesity.A growing number of symbiotic bacteria used as vectors for genetic engineering havebeen applied to create living therapeutics. In this study, using Bacillus subtilis as a cellularchassis,
: Kefir beverage is a probiotic food associated with health benefits, containing probioticmicroorganisms and biomolecules produced during fermentation. The microbial compositionof these beverages varies among countries, geographical regions, and the substrates, therefore,the characterization of kefir beverages is of great relevance in understanding their potential healthpromoting and biotechnological applications. Therefore, this study presents the metagenomic andfunctional