Probiotics, Prebiotics and Symbiotics

Neurogenic and anti-inflammatory effects of probiotics in Parkinson’s 3 disease: a systematic review of preclinical and clinical evidence

Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Findings from preclinical studies suggest that treatment with probiotics increased glucose metabolism (increased secretion of glucagon-like peptide-1), reduced peripheral and central inflammation (reduced interleukin-6 and tumor necrosis factor-α (TNF-α)), reduced peripheral and central oxidative stress (reduced peripheral superoxide anion levels and increased central antioxidant glutathione levels), decreased neurodegeneration (increased numbers of tyrosine hydroxylase dopaminergic neurons […]

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Neuroprotective effect of Lactobacillus plantarum DP189 on MPTP-induced Parkinson’s disease model mice

Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The results indicated that L. plantarum DP189 improved behavioral ability and increased the levels of 5-hydroxytryptamine and dopamine of PD mice. L. plantarum DP189 significantly increased the positive rate of tyrosine hydroxylase cells. L. plantarum DP189 activated the ERK2 and AKT/mTOR pathways, promoted the expression of Bcl-2, and inhibited the activities of Bax and Caspase 3. The results indicated that L. plantarum DP189

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Probiotics and the Treatment of Parkinson’s Disease: An Update

Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Probiotic supplementation mediates these pharmacological effects by targeting a variety of cellular and molecular processes, i.e., oxidative stress, inflammatory and anti-inflammatory pathways, as well as apoptosis. Herein, we summarize the effects of probiotics on motor and non-motor symptoms as well as various cellular and molecular pathways in PD. CLICK TO REVIEW

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Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

However, there is limited success in restoring healthy microbial biodiversity in AD and PD patients with general probiotics interventions and fecal microbial therapies. Fortunately, the gut microflora is susceptible to long-term extrinsic influences such as lifestyle and dietary choices, providing opportunities for treatment through comparatively individual-specific control of human behavior. In this review, weexamine the

Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases? Read More »

Influence of probiotic bacteria on gut microbiota composition and gut wall function in an in-vitro model in patients with Parkinson’s disease

Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

In general, the relative proportions of the main bacterial phyla in the microbiotas of PD patients differed from those of healthy subjects, with levels of Firmicutes raised and levels of Bacteroidetes reduced. Dosing with probiotic resulted in a change in bacterial composition in the microbiotas over a 48 h period. Several other indicators of gut health changed upon dosing with

Influence of probiotic bacteria on gut microbiota composition and gut wall function in an in-vitro model in patients with Parkinson’s disease Read More »

Impact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity

Diet and Exercise, Herbs & Spices, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

: The average life expectancy of the world population has increased remarkably in the past150 years and it is still increasing. A long life is a dream of humans since the beginning of time but also a dream is to live it in good physical and mental condition. Nutrition research has focused on recent decades

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Short-chain fatty acids-producing probiotics: A novel source of psychobiotics

Butyrate, Gut Dysbiosis, Gut-Brain axis, Metabolites, Mitochondria, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Psychobiotics—live microorganisms with potential mental health benefits, which can modulate the microbiota-gut-brain-axis via immune, humoral, neural, and metabolic pathways—are emerging as novel therapeutic options for the effective treatment of psychiatric disorders Recently, microbiome studies have identified numerous putative psychobiotic strains, of which short-chain fatty acids (SCFAs) producing bacteria have attracted special attention from neurobiologists. Recent

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Neurological disorders associated with impaired gut microbiota

Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Proinflammatory mediators such as iNOS, ROS, COX2 and NF-B are released by microglia, resulting in neuroinflammation in Alzheimer’s disease. It is becoming more widely recognized as a symptom of Autism Spectrum Disorder. The establishment of gut-brain psychology is expected to have a significant impact on psychology and related disciplines. CLICK TO REVIEW

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Bacterial Extracellular Vesicles and the Gut-Microbiota Brain Axis: Emerging Roles in Communication and Potential as Therapeutics

Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

Thus, BEVs may be both a cause of and solution to neuropathological conditions. In this review, current knowledge of the physiological roles of BEVs as well as state of the art pertaining to the development of therapeutic BEVs in the context of the microbiome-gut-brain axis are summarized. CLICK TO REVIEW

Bacterial Extracellular Vesicles and the Gut-Microbiota Brain Axis: Emerging Roles in Communication and Potential as Therapeutics Read More »

Ingestion of Bifidobacterium longum changes miRNA levels in the brains of mice

Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

As the profound interactions between the gut microbiota and the structure, chemistry, and activity of the brain continue to be discovered, the functional details of how the microbiota-gut-brain-axis works are starting to be resolved. Previous studies have suggested B. longum can cause changes in brain chemistry and activity [20]. Other research has revealed that modifications to expression of

Ingestion of Bifidobacterium longum changes miRNA levels in the brains of mice Read More »