Root Canal

Is amalgam removal in patients with medically unexplained physical symptoms cost-effective? A prospective cohort and decision modelling study in Norway

endondonics, Periodontitis, Root Canal /

There are many patients in general practice with health complaints that cannot be medically explained. Some of these patients attribute their health complaints to dental amalgam restorations. This study examined the cost-effectiveness of the removal of amalgam restorations in patients with medically unexplained physical symptoms (MUPS) attributed to amalgam fillings compared to usual care, based […]

Is amalgam removal in patients with medically unexplained physical symptoms cost-effective? A prospective cohort and decision modelling study in Norway Read More »

Self-reported periodontitis and C-reactive protein in
Parkinson’s disease: a cross-sectional study of
two American cohorts

endondonics, Oral Microbiome, Parkinson's Disease, Periodontitis, Root Canal /

Periodontitis triggers systemic repercussions, such as elevated levels of high-sensitive C-reactive protein (hs-CRP). This has neverbeen studied within Parkinson’s Disease (PD). The aim of this study is to compare hs-CRP levels of self-reported periodontitis casesversus cases without periodontitis in PD patients. Data from the National Health and Nutrition Examination Survey (2015–2016 and2017–2018 waves) were analyzed.

Self-reported periodontitis and C-reactive protein in
Parkinson’s disease: a cross-sectional study of
two American cohorts Read More »

Facts and controversies regarding oral health in Parkinson’s disease:
A case-control study in Spanish patients

Diet and Exercise, endondonics, Oral Microbiome, Parkinson's Disease, Pre-PD, Root Canal /

Oral disorders are frequent in PD. Good knowledge of these alterations will allow us to design a specific preventive protocol. Some oral alterations may be a sign of diagnostic alert or progression of PD. CLICK TO REVIEW

Facts and controversies regarding oral health in Parkinson’s disease:
A case-control study in Spanish patients Read More »

Microbial pathogens induce neurodegeneration in Alzheimer’s disease mice: protection by microglial regulation

Enviromental, Parkinson's Disease, Root Canal, Viral / Bacterial Infections, Virus /

Exposure to systemic infections causes neurodegeneration in brain regions displaying amyloid pathology and high local microglia density. AD brains exhibit increased susceptibility to microbial PAMPs’ neurotoxicity, which accelerates neuronal death. Microglial modulation protects the brain from microbial TLR agonist PAMP-induced neurodegeneration. CLICK TO REVIEW

Microbial pathogens induce neurodegeneration in Alzheimer’s disease mice: protection by microglial regulation Read More »

Gingival Crevicular Fluid as Biomarker’s Source for Alzheimer’s Disease

Oral Microbiome, Parkinson's Disease, Periodontitis, Pre-PD, Root Canal /

Periodontitis is a low-grade inflammatory disease caused by a subgingivaldysbiotic microbiota. Multiple studies have determined the higher prevalence of toothloss and poor oral hygiene in patients with Alzheimer’s disease (AD). However, theperiodontal diagnosis, periodontal bacteria or mediators has not been measuredto date. Aim: To determine the periodontal status, the pro-inflammatory mediators,Porphyromonas gingivalis load, and Apoliporpotein

Gingival Crevicular Fluid as Biomarker’s Source for Alzheimer’s Disease Read More »

Is There Any Association Between Neurodegenerative Diseases and Periodontitis? A Systematic Review

Periodontitis, Root Canal /

All the included studies reported higher levels of inflammatory markers, IgG levels of periodontal bacteria, and/or clinical parameters of periodontitis with the two concomitant diseases (some neurodegenerative disease and periodontitis), compared with the diseases isolated (summarized in Figure 2). Despite that we found some minor problems in domains in the qualitative analysis, all the studies have

Is There Any Association Between Neurodegenerative Diseases and Periodontitis? A Systematic Review Read More »

Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life

Endotoxin, Lipopolysaccharides (LPS), Root Canal /

CAP-related depression was accompanied by increased levels of NOx, LOOH, AOPP, and TRAP. In CAP participants, there was a strong correlation (r = 0.734, p < 0.001) between root canal LPS and the HDRS score. There were significant and positive associations between CAP or root canal endotoxin with the vegetative and physiosomatic symptoms of the

Increased Root Canal Endotoxin Levels are Associated with Chronic Apical Periodontitis, Increased Oxidative and Nitrosative Stress, Major Depression, Severity of Depression, and a Lowered Quality of Life Read More »