Short Chain Fatty Acids

Gut microbiota and inflammation in
Parkinson’s disease: Pathogenetic and
therapeutic insights

A-Synuclein, Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuronal loss andα-synuclein (α-syn) aggregation. With the acceleration of population aging process, the incidence of PD is expected toincrease, putting a heavy burden on the whole society. Recent studies have found the alterations of gut microbiota (GM) inPD patients and the clinical relevance of […]

Gut microbiota and inflammation in
Parkinson’s disease: Pathogenetic and
therapeutic insights Read More »

The potential applications of traditional Chinese medicine in Parkinson’s disease: A new opportunity

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Parkinson’s disease (PD) presents a common challenge for people all over the world and has become a major research hotspot due to the large population affected by the illness and the difficulty of clinical treatment. The prevalence of PD is increasing every year, the pathogenesis is complex, and the current treatment is ineffective. Therefore, it has

The potential applications of traditional Chinese medicine in Parkinson’s disease: A new opportunity Read More »

The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Short Chain Fatty Acids /

Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attracted significant attention. Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders. Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases. Maintaining a healthy gut microbiota is essential

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Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases

Anti-oxidants, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The global prevalence of Alzheimer’s disease and Parkinson’s disease is steadily increasing due to the aging population. The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment. Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may

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THE MICROBIOTA-GUT-BRAIN AXIS

A-Synuclein, Butyrate, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However,the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms withinand on our bodies) as one of the key regulators of gut-brain function and has led to the appreciationof the importance of a distinct microbiota-gut-brain axis.This axis

THE MICROBIOTA-GUT-BRAIN AXIS Read More »

Positive Interventional Effect of Engineered Butyrate-Producing
Bacteria on Metabolic Disorders and Intestinal Flora Disruption
in Obese Mice

Butyrate, Metabolites, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The substantially increased prevalence of obesity and obesity-relateddiseases has generated considerable concern. Currently, synthetic biological strategieshave played an essential role in preventing and treating chronic diseases such as obesity.A growing number of symbiotic bacteria used as vectors for genetic engineering havebeen applied to create living therapeutics. In this study, using Bacillus subtilis as a cellularchassis,

Positive Interventional Effect of Engineered Butyrate-Producing
Bacteria on Metabolic Disorders and Intestinal Flora Disruption
in Obese Mice Read More »

Metagenomic and Functional Characterization of Two Chilean
Kefir Beverages Reveals a Dairy Beverage Containing Active
Enzymes, Short-Chain Fatty Acids, Microbial β-Amyloids,
and Bio-Film Inhibitors

Gut Microbiota, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

: Kefir beverage is a probiotic food associated with health benefits, containing probioticmicroorganisms and biomolecules produced during fermentation. The microbial compositionof these beverages varies among countries, geographical regions, and the substrates, therefore,the characterization of kefir beverages is of great relevance in understanding their potential healthpromoting and biotechnological applications. Therefore, this study presents the metagenomic andfunctional

Metagenomic and Functional Characterization of Two Chilean
Kefir Beverages Reveals a Dairy Beverage Containing Active
Enzymes, Short-Chain Fatty Acids, Microbial β-Amyloids,
and Bio-Film Inhibitors Read More »

Bacteria-Derived Protein Aggregates Contribute to the Disruption of Host Proteostasis

A-Synuclein, Butyrate, Parkinson's Disease, Short Chain Fatty Acids /

Neurodegenerative protein conformational diseases are characterized by misfolding and aggregation of metastable proteins encoded within the host genome. The host is also home to thousands of proteins encoded within exogenous genomes harbored by bacteria, fungi, and viruses. Yet, their contributions to host protein-folding homeostasis, or proteostasis, remain elusive. Recent studies, including our previous work, suggest

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Butyrate Inhibits Osteoclast Activity In Vitro and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic-Treated Mice

Butyrate, Gut Microbiota, Parkinson's Disease, Short Chain Fatty Acids /

Short-chain fatty acids (SCFAs) produced by the gut microbiota have previously been demonstrated to play a role in numerous chronic inflammatory diseases and to be key mediators in the gut-bone signaling axis. However, the role of SCFAs in bone fracture healing and its impact on systemic inflammation during the regeneration process has not been extensively

Butyrate Inhibits Osteoclast Activity In Vitro and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic-Treated Mice Read More »

Short-Chain Fatty Acids Modulate Healthy Gut Microbiota Composition and Functional Potential

Biomarkers, Butyrate, Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids /

Many studies have focused on the metabolic capacity of human gut microbiota to produce short-chain fatty acids and subsequent effects on host physiology. Given scarce data on how SCFAs produced by gut bacteria participate in cross-feeding to influence community structure and function, we evaluated the potential of SCFAs to modulate human gut microbiota in vitro.

Short-Chain Fatty Acids Modulate Healthy Gut Microbiota Composition and Functional Potential Read More »