Short Chain Fatty Acids

Dual role of microbiota-derived short-chain fatty acids on host and pathogen

Butyrate, Gut Microbiota, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

A growing body of documents shows microbiota produce metabolites such as short-chain fatty acids (SCFAs) as crucial executors of diet-based microbial influence the host and bacterial pathogens. The production of SCFAs depends on the metabolic activity of intestinal microflora and is also affected by dietary changes. SCFAs play important roles in maintaining colonic health as […]

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The Role of Dysbiosis in Neurological Disorders

Biomarkers, Butyrate, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Metabolites, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The gut brain axis is a system of bi-directional communication. When the delicate balance of the microbiome is disrupted, the resulting dysbiosis can be a factor in the development of neurological disorders, including Alzheimer’s Disease (AD), Parkinson’s Disease (PK), and Multiple Sclerosis (MS). One major player in the gut brain axis are short-chain fatty acids

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Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut

Biomarkers, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

With the increasing amount of evidence linking certain disorders of the human body to a disturbed gut microbiota, there is a growing interest for compounds that positively influence its composition and activity through diet. Besides the consumption of probiotics to stimulate favorable bacterial communities in the human gastrointestinal tract, prebiotics such as inulin-type fructans (ITF)

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Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease

Fecal Transplants (FMT), Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids, Vagal Nerve /

In recent years, human gut microbiota have become one of the most promising areasof microorganism research; meanwhile, the inter-relation between the gut microbiota and varioushuman diseases is a primary focus. As is demonstrated by the accumulating evidence, the gastrointestinal tract and central nervous system interact through the gut–brain axis, which includesneuronal, immune-mediated and metabolite-mediated pathways.

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Short-chain fatty acids as modulators of redox signaling in health and disease

Butyrate, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet, have been linked to beneficial effects on human health associated with their metabolic and signaling properties. Their physiological functions are related to their aliphatic tail length and dependent on the activation of specific membrane receptors. In this review, we focus on the mechanisms underlying

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Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids /

As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal immune cells of this organ. Microglial features are strongly dependent on environmental cues such as commensal microbiota. Gut bacteria are known to continuously modulate microglia maturation and function by the production of short-chain fatty acids (SCFAs). However, the precise mechanism of this crosstalk is unknown. Here we determined that

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Microbiota in Health and Disease—Potential Clinical Applications

A-Synuclein, Butyrate, Diet and Exercise, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids, Vagal Nerve /

: Within the last two decades tremendous efforts in biomedicine have been undertaken tounderstand the interplay of commensal bacteria living in and on our human body with our ownhuman physiology. It became clear that (1) a high diversity especially of the microbial communitiesin the gut are important to preserve health and that (2) certain bacteria

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Treating chronic diseases by regulating the gut microbiota

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

Chronic diseases encompass a wide range of illnesses, ranging from cardiovascular and cerebrovascular diseases, metabolic syndromes to degenerative neurological disorders. Chronic diseases are responsible for most observed morbidity and mortality in the developed countries as well as in some developing countries. The gut microbiota and its metabolites have been associated with the onset and development

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Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion

Butyrate, Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids /

Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC). However, very little is currently known about whether and how gut microbiota alterations are causally associated with CRC development. Here we show that 12 faecal bacterial taxa are enriched in CRC patients in two independent cohort studies. Among them, 2 Porphyromonas species

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Parkinson’s disease patients’ short chain fatty acids production capacity after in vitro fecal fiber fermentation

Butyrate, Diet and Exercise, Gut Permeability / Leaky Gut, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Short-chain fatty acid production was analyzed by headspace solid-phase micro-extraction gas chromatography-mass spectrometry. Clostridium coccoides and C. leptum were quantified through 16S-rRNA gene-targeted group-specific qPCR. Factors influencing short-chain fatty acid production were investigated using linear mixed models. After fiber fermentation, butyrate concentration varied between 25.6 ± 16.5 µmol/g and 203.8 ± 91.9 µmol/g for Parkinson’s patients and between 52.7 ± 13.0 µmol/g and 229.5 ± 42.8 µmol/g for controls. Inulin had

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