Short Chain Fatty Acids

IMPACT OF THE SHORT – CHAIN FATTY ACIDS ON THE MICROBIOTA – GUT – BRAIN AXIS

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

Studies show that short – chain fatty acids have differenteffects by increasing or decreasing the quantity of certain molecules such as GLP-1,peptide YY, insulin, glucagon, ghrelin, leptin and serotonin while they also have animpact on the nervous system. Also is needed to emphasize its role in certainneurological diseases such as Parkinson, autism spectrum disorder and […]

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Dietary patterns affect Parkinson’s disease via the microbiota-gut-brain axis

Diet and Exercise, Gut Microbiota, Short Chain Fatty Acids /

The Mediterranean diet reduces the risk of PD with favorable alternations of intestinal microbiota, increases levels of SCFAs, and reduces the TMAO level. Calorie restriction and Fasting-mimicking diet show some neuroprotective effects on PD via increasing β-HB, FGF21, and Ghrelin levels. Meanwhile, both ketogenic and protein-restricted diets show a striking effect on ameliorating motor impairment

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Influence of probiotic bacteria on gut microbiota composition and gut wall function in an in-vitro model in patients with Parkinson’s disease

Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

In general, the relative proportions of the main bacterial phyla in the microbiotas of PD patients differed from those of healthy subjects, with levels of Firmicutes raised and levels of Bacteroidetes reduced. Dosing with probiotic resulted in a change in bacterial composition in the microbiotas over a 48 h period. Several other indicators of gut health changed upon dosing with

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Short-chain fatty acids-producing probiotics: A novel source of psychobiotics

Butyrate, Gut Dysbiosis, Gut-Brain axis, Metabolites, Mitochondria, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Psychobiotics—live microorganisms with potential mental health benefits, which can modulate the microbiota-gut-brain-axis via immune, humoral, neural, and metabolic pathways—are emerging as novel therapeutic options for the effective treatment of psychiatric disorders Recently, microbiome studies have identified numerous putative psychobiotic strains, of which short-chain fatty acids (SCFAs) producing bacteria have attracted special attention from neurobiologists. Recent

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Cross-Reactivity and Sequence Homology Between Alpha-Synuclein and Food Products: A Step Further for Parkinson’s Disease Synucleinopathy

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Herbs & Spices, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The cross-reactivity and sequence homology between α-synuclein and frequently consumed foods, reinforces the autoimmune aspect of Parkinson’s disease. It is hypothesized that luminal food peptides that share cross-reactive epitopes with human α-synuclein and have molecular similarity with brain antigens are involved in the synucleinopathy. The findings deserve further confirmation by extensive research. CLICK TO REVIEW

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Exploration of Host Health Benefits by a Defined Consortium of Butyrate-Producing Human Gut Bacteria In Gnotobiotic Mouse Model

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Metabolites, Mitochondria, Short Chain Fatty Acids /

Aberrant gut microbiota composition is found to be associated with several human diseases such as inflammatory bowel diseases (IBD). Reduction in butyrate producing bacteria is one of the characteristic features of such dysbiotic bacterial community in the gut. Modulation of gut microbiota to bring the dysbiotic state back to normal healthy state is a promising

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Identification and Characterization of Butyrate-Producing Species in the Human Gut Microbiome

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Mitochondria, Short Chain Fatty Acids /

Inflammatory Bowel Diseases (IBD) including ulcerative colitis, Crohn’s disease, and indeterminate colitis are increasingly common conditions that places a high physical and financial burden on individuals and global healthcare systems. Though treatments exist for these conditions, their unpredictable nature and causation make them difficult to manage consistently across the variety of IBD patients. Additionally, many

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The gut microbiome: implications for neurogenesis and neurological diseases

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Short Chain Fatty Acids /

The gut microbiome has also gained increasing attention in PD, and its involvement has been strongly implicated in the modulation of this disease. Microbiota analysis has revealed increased Enterobacteria and decreased Prevotella strains in patients with PD (Scheperjans et al., 2015). Another clinical study found that, compared with healthy controls, patients with PD exhibited decreases in a range of

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Supplementation of regular diet with medium-chain triglycerides for neuroprotective effects

Diet and Exercise, Short Chain Fatty Acids /

This review summarizes currently available research on the effects and revealed mechanisms of using MCTs as a supplement to standard feed/diet without concomitant reduction of carbohydrate intake, highlighting open questions and potential considerations.

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Role of microbiota-derived short-chain fatty acids in nervous system disorders

Butyrate, Gut Microbiota, Short Chain Fatty Acids /

It has been noted remodeling in the gut microbiota metabolites associated with the pathophysiology of several neurological disorders, such as Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, amyotrophic lateral sclerosis, stress, anxiety, depression, autism, vascular dementia, schizophrenia, stroke, and neuromyelitis optica spectrum disorders, among others. This review will discuss the current evidence from the most significant studies dealing with some SCFAs from gut microbial metabolism with selected neurological disorders. CLICK

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