Symptoms / Diagnosis

Clinical characteristics of newly diagnosed Parkinson’s disease patients included in the longitudinal BIO-PD study

Biomarkers, Pre-PD, Symptoms / Diagnosis /

The frequencies of symptoms and abnormal findings in PD patients were as follows: hyposmia 82.4%, substantia nigra hyperechogenicity 75.4%, history of anxiety or depression disorder 29.5%, constipation 22.1%, and REM (rapid eye movement) sleep behavior disorder 22%. Conclusion: Baseline characteristics of patients enrolled in the BIO-PD study are comparable to other de novo PD cohorts, […]

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A narrative review of relationship between gut microbiota and neuropsychiatric disorders: mechanisms and clinical application of probiotics and prebiotics

Gut Microbiota, Probiotics, Prebiotics and Symbiotics, Symptoms / Diagnosis, Therapies /

Current research shows that probiotics and prebiotics have a good preventive effect on Alzheimer’s disease, Parkinson’s disease, depression, autism spectrum disorders and other neurological and mental diseases. Based on this, we review the relevant research on the pathogenesis of probiotics and prebiotics and neuropsychiatric diseases, in an attempt to providing new ideas for exploring the

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Why Researchers Look to Gut Microbial Metabolites in Parkinson’s Disease

Gut Microbiota, Gut Permeability / Leaky Gut, Metabolites, Short Chain Fatty Acids, Symptoms / Diagnosis /

Findings highlight significant differences in the fecal microbiome and metabolome in patients with Parkinson’s disease and control subjects, demonstrating an important connection between the brain and gut that could influence the disease process and progression. CLICK TO REVIEW

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Smell tests to distinguish Parkinson’s disease from other neurological disorders: a systematic review and meta-analysis

Biomarkers, Olfactory, Pre-PD, Symptoms / Diagnosis /

Olfactory impairment has been considered for differential diagnosis in Parkinson’s Disease (PD) patients. The authors aimed to identify the tests used to assess the olfactory function in PD patients and examine these tests’ ability to distinguish them from other neurological disorders. CLICK TO REVIEW

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PREMOTOR PARKINSON’S DISEASE: OVERVIEW OF CLINICAL SYMPTOMS AND CURRENT DIAGNOSTIC METHODS

Biomarkers, iRBD, Pre-PD, Symptoms / Diagnosis /

The best known premotor symptoms include hyposmia, REM sleep behavior disorder (RBD), constipation, and depression; other symptoms are excessive daytime somnolence, orthostatic hypotension and symptomatic hypotension, erectile or urinary dysfunction, musculoskeletal symptoms, pain, and global cognitive deficit. In this review, we summarize currently available diagnostic methods for these symptoms. We also briefly summarize neuroimaging, polyneuropathy,

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Interrelationship between Gut microbiota and Parkinson’s disease

Gut Microbiota, Gut-Brain axis, Mitochondria, Symptoms / Diagnosis /

There is a bidirectional communication between the brain and the gut called “gutmicrobiota-brain axis (GMBA)” and its dysfunction causes numerous diseases. This review focuses on theinter-relationship between the gut microbiome and the Parkinson’s disease.(4) (PDF) Interrelationship between Gut microbiota and Parkinson’s disease. Available from: https://www.researchgate.net/publication/346456083_Interrelationship_between_Gut_microbiota_and_Parkinson’s_disease [accessed Jan 31 2021].

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Clinical Phenotypes of Parkinson’s Disease Associate with Distinct Gut Microbiota and Metabolome Enterotypes

Gut Microbiota, Gut-Brain axis, Pre-PD, Symptoms / Diagnosis /

We hypothesize that themicrobiota/metabolome enterotypes associated to non-TD subtypes may favor the developmentof gut inflammatory environment and gastrointestinal dysfunctions and therefore a more severeα-synucleinopathy. This study adds important information to PD pathogenesis and emphasizes thepotential pathophysiological link between gut microbiota/metabolites and PD motor subtypes(PDF) Clinical Phenotypes of Parkinson’s Disease Associate with Distinct Gut Microbiota and

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Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease

Biomarkers, Pre-PD, Symptoms / Diagnosis /

Parkinson’s disease (PD) is a debilitating neurodegenerative disorder in which nonmotor symptoms, such as constipation and hyposmia, precede the onset of motor symptoms by 20 years. The aim of this study was to identify biomarkers at the premotor stage of PD. We assessed the differences in longitudinal changes in anthropometric and serological indices obtained from health

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Acupoint Massage Therapy Alters the Composition of Gut Microbiome in Functional Constipation Patients

Biomarkers, Gut Dysbiosis, Gut Microbiota, Symptoms / Diagnosis /

The 16S KEGG function prediction suggested that Parkinson disease, retinol metabolism, and arachidonic acid metabolism could explain the biological function of different gut microbiome. Furthermore, cytokines in the serum showed a correlation with the abundance of Pseudobutyrivibrio in CFC. Conclusion. AMT could change the composition of gut microbiome which is associated with cytokines in CFC patients. CLICK TO

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