Therapies

Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson’s disease.Prevention of neuroinflammation in Parkinson’s disease

Diet and Exercise, Fasting, Parkinson's Disease, Therapies /

Parkinson’s disease (PD) is the second most common age-associated neurodegenerative disorder and is characterized by progressive loss of dopamine neurons in the substantia nigra. Peripheral immune cell infiltration and activation of microglia and astrocytes are observed in PD, a process called neuroinflammation. Neuroinflammation is a fundamental response to protect the brain but, when chronic, it […]

Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson’s disease.Prevention of neuroinflammation in Parkinson’s disease Read More »

Toward Precision Medicine: Effects of the Common VAL66met BDNF Variant in the Aging Brain and Implications for the Future of Parkinson’S Disease Therapeutics

Parkinson's Disease, Therapies /

In this rapidly evolving era of precision medicine, understanding mechanisms underlying the beneficial versus detrimental impact of the Val66Metpolymorphism, and/or its interaction with aging, will aid in the development of safe and optimized therapeutic approaches for remodeling the parkinsonian striatum. CLICK TO REVIEW

Toward Precision Medicine: Effects of the Common VAL66met BDNF Variant in the Aging Brain and Implications for the Future of Parkinson’S Disease Therapeutics Read More »

Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models

Anti-oxidants, Diet and Exercise, Parkinson's Disease, Therapies /

Therefore, the use of natural antioxidants in PD may provide an alternative therapy that prevents oxidative stress and reduces disease progression. In this review, the effects of hydroxytyrosol, Ginkgo biloba, Withania somnifera, curcumin, green tea, and Hypericum perforatum in PD animal and cell line models are compared and discussed. The reviewed antioxidants show evidence of protecting neural cells from

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Unravelling the potential of gut microbiota in sustaining brain health and their current prospective towards development of neurotherapeutics

Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics, Therapies /

Reports also showed that colonization of gut microbiota isolated from patients suffering from neurodegenerative disease leads to the development of enhance pathological outcomes in animal models. Hence, a systematic understanding of the dominant role of specific gut microbiome towards development of different neurodegenerative diseases could possibly provide novel insight into the use of probiotics and

Unravelling the potential of gut microbiota in sustaining brain health and their current prospective towards development of neurotherapeutics Read More »

Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota

Gut Dysbiosis, Gut Microbiota, Therapies /

The L-dopa produced by the intestinal bacteria enters the brain through the circulation and is transformed to dopamine. To verify the gut–brain dialog activated by BBR’s effect, Enterococcus faecalis or Enterococcus faecium was transplanted into Parkinson’s disease (PD) mice. The bacteria significantly increased brain dopamine and ameliorated PD manifestation in mice; additionally, combination of BBR with bacteria showed better therapeutic

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Effects of Resistant Starch on Symptoms, Fecal Markers and Gut Microbiota in Parkinson’s Disease – The RESISTA-PD Trial

Butyrate, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids, Therapies /

Clinically, we observed a reduction in non-motor symptoms load in PD + RS. The reference-based analysis of metagenomes highlighted stable alpha-diversity and beta-diversity across the three groups, including bacteria producing SCFAs. Reference-free analysis suggested punctual, yet pronounced differences in the metagenomic signature in PD + RS. RESISTA-PD highlights that a prebiotic treatment with RS is

Effects of Resistant Starch on Symptoms, Fecal Markers and Gut Microbiota in Parkinson’s Disease – The RESISTA-PD Trial Read More »

A narrative review of relationship between gut microbiota and neuropsychiatric disorders: mechanisms and clinical application of probiotics and prebiotics

Gut Microbiota, Probiotics, Prebiotics and Symbiotics, Symptoms / Diagnosis, Therapies /

Current research shows that probiotics and prebiotics have a good preventive effect on Alzheimer’s disease, Parkinson’s disease, depression, autism spectrum disorders and other neurological and mental diseases. Based on this, we review the relevant research on the pathogenesis of probiotics and prebiotics and neuropsychiatric diseases, in an attempt to providing new ideas for exploring the

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Fecal transplants as a microbiome-based therapeutic

Fecal Transplants (FMT), Therapies /

Impaired microbiome diversity and composition can develop into a potent etiological agent of disease and increase susceptibility to infection. Given this, interventions targeting the microbiome have developed rapidly, with healthy donor feces being a de facto source of beneficial communities employed to rebalance patients’ microbiomes. Recent evidence has demonstrated that bacterial and viral richness, short

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