Vitamins / Supplements / Nutraceuticals

Identification of components of turmeric as potential therapeutic agents to
slow the progression of neurodegeneration in Parkinson’s disease

A-Synuclein, Diet and Exercise, Vitamins / Supplements / Nutraceuticals /

Parkinson’s disease (PD) is a neurological disorder associated with severe loss of dopaminergic neurons inthe substantia nigra. These neurons are particularly vulnerable due to increased iron and decreasedantioxidant levels with aging, constant exposure to reactive oxygen species (ROS), and the presence ofneurotoxic compounds. A literature review was compiled and published, in which we postulate that […]

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slow the progression of neurodegeneration in Parkinson’s disease Read More »

The Mediterranean Diet as a Source of Bioactive Molecules with
Cannabinomimetic Activity in Prevention and Therapy Strategy

Herbs & Spices, Vitamins / Supplements / Nutraceuticals /

The endocannabinoid system is a complex lipid signaling network that has evolved tobe a key regulator of pro-homeostatic pathways for the organism. Its involvement in numerousprocesses has rendered it a very suitable target for pharmacological studies regarding metabolicsyndrome, obesity and other lifestyle-related diseases. Cannabinomimetic molecules have beenfound in a large variety of foods, most of

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Cannabinomimetic Activity in Prevention and Therapy Strategy Read More »

Chinese herbal medicine treatment based on subgroup differentiation as adjunct therapy for Parkinson’s disease: study protocol of a pilot add-on, randomised, controlled, pragmatic clinical trial

Diet and Exercise, Herbs & Spices, Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

Background Parkinson’s disease (PD) is a prevalent and debilitating condition. Conventional medications cannot control all symptoms and may inflict adverse effects. A survey reported that Chinese herbal medicine (CHM) is frequently sought. Existing CHM trials were contradictory and often of poor quality due to lack of methodological rigor. A national clinical guideline was drafted in

Chinese herbal medicine treatment based on subgroup differentiation as adjunct therapy for Parkinson’s disease: study protocol of a pilot add-on, randomised, controlled, pragmatic clinical trial Read More »

Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease

Anti-oxidants, Autophagy, Diet and Exercise, Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

first_pagesettingsOpen AccessArticle Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease by Hitesh Singh Chaouhan 1,†,Xin Li 1,†,Kuo-Ting Sun 2,3,†,I-Kuan Wang 4,5,Tung-Min Yu 6,7,Shao-Hua Yu 8,Kuen-Bao Chen 9,*,Wei-Yong Lin 10,11,12,* andChi-Yuan Li 1,9,*1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan2Department of Pediatric Dentistry, China Medical University Hospital, Taichung 40402, Taiwan3School of Dentistry, China Medical University, Taichung

Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease Read More »

Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models

Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

Parkinson’s disease (PD) is a neurodegenerative disordercharacterized by a progressive loss of dopaminergic neu-rons in the substantia nigra (SN). The present study wasdesigned to examine the therapeutic effect of hydrogensulfide (H2S, a novel biological gas) on PD. The endoge-nous H2S level was markedly reduced in the SN in a6-hydroxydopamine (6-OHDA)-induced PD rat model. Sys-temic administration

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Treating chronic diseases by regulating the gut microbiota

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

Chronic diseases encompass a wide range of illnesses, ranging from cardiovascular and cerebrovascular diseases, metabolic syndromes to degenerative neurological disorders. Chronic diseases are responsible for most observed morbidity and mortality in the developed countries as well as in some developing countries. The gut microbiota and its metabolites have been associated with the onset and development

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Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Vitamins / Supplements / Nutraceuticals /

Berberine (BBR), an isoquinoline alkaloid, has been found in many plants, such as Coptis chinensis Franch. and Phellodendron chinense Schneid. Although BBR has a wide spectrum of pharmacological effects, its oral bioavailability is extremely low. In recent years, gut microbiota has emerged as a cynosure to understand the mechanisms of action of herbal compounds. Numerous studies have demonstrated that,

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Circulatory 25(OH)D and 1,25(OH)2D as differential biomarkers between multiple system atrophy and Parkinson’s disease patients

Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

There is sufficient evidence to support vitamin D’s noncalcemic effects and the role ofvitamin D deficiency in the development of a wide range of neurological disorders. This study aimed to evaluatewhether serum 25(OH)D and 1,25(OH) 2 D could be used as biomarkers to differentiate between healthy subjects(HS), multiple system atrophy (MSA) and Parkinson’s disease (PD)

Circulatory 25(OH)D and 1,25(OH)2D as differential biomarkers between multiple system atrophy and Parkinson’s disease patients Read More »