Vitamins / Supplements / Nutraceuticals

Vitamin C Supplementation in Healthy Individuals Leads to Shifts of Bacterial Populations in the Gut—A Pilot Study

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Vitamins / Supplements / Nutraceuticals /

Daily supplementation of high-dose vitamin C led to an increase in the relative abundances of Lachnospiraceae (p < 0.05), whereas decreases were observed for Bacteroidetes (p < 0.01), Enterococci (p < 0.01) and Gemmiger formicilis (p < 0.05). In addition, trends for bacterial shifts were observed for Blautia (increase) and Streptococcus thermophilus (decrease). High-dose vitamin […]

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The Role of Melatonin and Disrupted Sleep in Neurologic Disorders

Sleep, Vitamins / Supplements / Nutraceuticals /

Disordered sleep, often linked to abnormal levels of the hormone melatonin, occurs in many if not most neurologic disorders, and can often benefit from clinical treatment, according to a growing body of research that was presented during a scientific session at the virtual AAN Annual Meeting. CLICK TO REVIEW

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Elucidating the Multi‐Targeted Role of Nutraceuticals: A Complementary Therapy to Starve Neurodegenerative Diseases

Vitamins / Supplements / Nutraceuticals /

The current review summarizes the popular nutraceuticals showing different effects (anti‐inflammatory, antioxidant, neuro‐protectant, mitochondrial homeostasis, neurogenesis promotion,and autophagy regulation) on vital molecular mechanisms involved in NDs, which can beconsidered as complementary therapy to first‐line treatment. Moreover, owing to its natural source, lower toxicity, therapeutic interventions, biocompatibility, potential nutritional effects, and presence of various anti‐oxidative and

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Natural polyphenols in central nervous system disorders

Parkinson's Disease, Polyphenols, Vitamins / Supplements / Nutraceuticals /

Reduced oxidative stress causes the suppression of the risk of associated neurodegenerative diseases, such as, Alzheimer’s disease (AD), stroke, multiple sclerosis (MS), Parkinson’s disease (PD) and Huntington’s disease (HD). Consequently, the analysis indicates that polyphenol beneficial effects on human brain activity and this review describe these implications by discussing the latest mechanistic hypothesis. CLICK TO

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Herbal medicine WangShiBaoChiWan improves gastrointestinal health in mice via modulation of intestinal tight junctions and gut microbiota and inhibition of inflammation

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Vitamins / Supplements / Nutraceuticals /

WSBCW upregulated intestinal junction proteins, increased the abundance of Bifidobacterium genus, Desulfovibrio genus and inhibited Bacteroides fragillis group in the gut microbiota, increased intestinal villi lengths, and decreased blood levels of inflammatory cytokines. Our study provided preclinical evidence to verify the effectiveness of WSBCW in gastrointestinal health and elucidate mechanistic insights. The results warrant further investigations to evaluate the

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Effects of niacin on intestinal immunity, microbial community and intestinal barrier in weaned piglets during starvation

Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Pre-PD, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

In conclusion, niacin attenuated the weight loss and diarrhea, and improved the expression of antimicrobial peptides, and enhanced intestinal epithelial barrier function, and improved the microbiota in the colonic contents of weaned piglets, suggesting that niacin may be an effective way for weaned piglets to maintain the gut and overall health. CLICK TO REVIEW

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Role of HCA2 in Regulating Intestinal Homeostasis and Suppressing Colon Carcinogenesis

Butyrate, Gut Microbiota, Metabolites, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

Hydroxycarboxylic acid receptor 2 (HCA2) is vital for sensing intermediates of metabolism, including β-hydroxybutyrate and butyrate. It also regulates profound anti-inflammatory effects in various tissues, indicating that HCA2 may serve as an essential therapeutic target for mediating inflammation-associated diseases. Butyrate and niacin, endogenous and exogenous ligands of HCA2, have been reported to play an essential role

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Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome– a pilot study

Anti-oxidants, Butyrate, Gut Microbiota, Metabolites, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

The modulatory effect of vitamins on the gut microbiome and related host health benefits remain largely unclear. We investigated the effects of colon-delivered vitamins A, B2, C, D, and E on the gut microbiota using a human clinical study and batch fermentation experiments, in combination with cell models for the assessment of barrier and immune

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Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials

Anti-oxidants, Diet and Exercise, Pre-PD, Vitamins / Supplements / Nutraceuticals /

Author links open overlay panelIn vitro and in vivo studies have associated astaxanthin’s unique molecular features with several health benefits, including neuroprotective, cardioprotective and antitumoral properties, suggesting its therapeutic potential for the prevention or co-treatment of dementia, Alzheimer, Parkinson, cardiovascular diseases and cancer. Benefits on skin and eye health promotion have also been reported, highlighting its

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Hydrogen-rich water as a modulator of gut microbiota?

Anti-oxidants, Vitamins / Supplements / Nutraceuticals /

However, no well-powered multicentric trial evaluated the effectiveness of HRW consumption so far in common gastrointestinal diseases with gut flora scenario, including inflammatory bowel disease, irritable bowel syndrome, gastroenteritis and colitis of infectious origin. HRW might be an up-and-coming compound that might tune endogenous H2 homeostasis and modulate gut microbiota but it should still be perceived

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