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N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

Ayahuasca, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Uncategorized /

N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our results demonstrate that DMT administration activates the main adult neurogenic niche, the subgranular zone of the dentate gyrus of […]

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The Complement System in the Central Nervous System:
From Neurodevelopment to Neurodegeneration

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The functions of the complement system to both innate and adaptive immunity throughopsonization, cell lysis, and inflammatory activities are well known. In contrast, the role of complement in the central nervous system (CNS) which extends beyond immunity, is only beginning to berecognized as important to neurodevelopment and neurodegeneration. In addition to protecting thebrain against invasive

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From Neurodevelopment to Neurodegeneration Read More »

A CLOSER LOOK AT THE MYCOBIOME IN ALZHEIMER’S DISEASE: FUNGAL SPECIES, PATHOGENESIS AND TRANSMISSION

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Candida spp., Malassezia spp., Cladosporium spp. and Alternaria spp are among the most common fungi detected in the brain of patients with Alzheimer’s disease (AD). These fungi are opportunistic organisms, where they often cause infection among immunocompromised patients. Coincidentally, these fungi can reach the brain and cause fungal meningitis. In general, they enter the brain via systemic infection due to disrupted epithelial

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Biological macromolecules acting on central nervous system

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Author links open overlay panel Biological macromolecules are built by the combination of smaller organic molecules. Carbohydrates, lipids, proteins, and nucleic acids are examples of such biological macromolecules. In this chapter, we discuss the role of these micro molecules on central nervous system (CNS). From various literature, it is observed that biological macromolecules are mainly

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Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview

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The blood-brain barrier (BBB) is a fundamental component of the central nervous system(CNS). Its functional and structural integrity is vital to maintain the homeostasis of the brain microenvironment by controlling the passage of substances and regulating the trafficking of immune cellsbetween the blood and the brain. The BBB is primarily composed of highly specialized microvascular

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What We Fund: $19 Million to Advance New Therapies and Study Environmental Risks

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The Michael J. Fox Foundation (MJFF) devotes our donor-raised dollars to the most promising scientific efforts to bring new treatments and cures closer to patient hands. In February and March, MJFF funded 56 new grants totaling nearly $19 million. https://www.michaeljfox.org/news/what-we-fund-19-million-advance-new-therapies-and-study-environmental-risks?em_cid=mc-a1b1R00000A5RyQ&et_cid=1855890&et_rid=574902244&et_lid=http%3a%2f%2fwww.michaeljfox.org%2fnews%2fwhat-we-fund-19-million-advance-new-therapies-and-study-environmental-risks%3fem_cid%3dmc-a1b1R00000A5RyQ

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An Overview of Alpha Synuclein Protein and Its Role in Parkinson’s disease

A-Synuclein, Dementia - Lewy Bodies, Uncategorized /

Under pathologic conditions, cellular accumulation of misfolded α-synuclein oligomers and aggregates are observed in a group of neurodegenerative diseases called synucleinopathies. The mechanisms of how α-synuclein protein takes part in the neurodegeneration process and physiologic roles of the protein have not been fully elucidated yet. It’s important to unravel the secrets of this protein and

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The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity

Autophagy, Mitochondria, Uncategorized /

The increased activity of mPTP in aging turns autophagy/mitophagy into a destructive process leading to cell aging and death. Several drugs and lifestyle modifications that enhance healthspan and lifespan enhance autophagy and inhibit the activation of mPTP. Therefore, elucidating the intricate connections between pathways that activate and inhibit mPTP, in the context of aging and

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