: Gut microbiota encompasses a wide variety of commensal microorganisms consisting of
trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with the host,
and related metabolites have profound effects on human health. In this respect, gut microbiota plays
a pivotal role in the regulation of metabolic, endocrine, and immune functions. Bacterial metabolites
include the short chain fatty acids (SCFAs) acetate (C2), propionate (C3), and butyrate (C4), which
are the most abundant SCFAs in the human body and the most abundant anions in the colon. SCFAs
are made from fermentation of dietary fiber and resistant starch in the gut. They modulate several
metabolic pathways and are involved in obesity, insulin resistance, and type 2 diabetes. Thus, diet
might influence gut microbiota composition and activity, SCFAs production, and metabolic effects.
In this narrative review, we discuss the relevant research focusing on the relationship between gut
microbiota, SCFAs, and glucose metabolism. CLICK TO REVIEW
Keywords: intestine; bacteria; metabolome; fiber; diet; glucose homeostasis